DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ack-like and epha7

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	XP_031758138.1	Gene:	epha7 / 100486526	XenbaseID:	XB-GENE-488635	Length:	1062	Species:	Xenopus tropicalis

Alignment Length:	352	Identity:	122/352 - (34%)
Similarity:	168/352 - (47%)	Gaps:	62/352 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 IPADSISVNKQLGTGEFGIVQQG-VWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHE 191
            :.|..|.:.:.:|.||||.|..| :...|...:.||||.|.....:....:||.||:||...:|.
Frog   648 LDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVPVAIKTLKVGYTEKQRRDFLCEASIMGQFDHP 712

  Fly   192 NIVRLYGVVLATDSLMLVTEL-------AHLRSLLE----CL---------KDSG-------LRV 229
            |:|.|.|||.....:|:|.|.       |.||...:    ||         |.||       ::|
Frog   713 NVVHLEGVVTRGKPVMIVIEFMENGALDAFLRQQQKKGKNCLEWFTSPPKSKRSGSTQTMPFVKV 777

  Fly   230 SFLTIP--------------TLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFG 280
            ..|..|              .|......|..|||||.....:|||||||||||.|....|:||||
Frog   778 QTLNTPGTNAQKLDGQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFG 842

  Fly   281 LSRALGVGKD-YYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAAL 344
            |||.:....| .|.|...   |:|:.|.|||.|.|.:||:|||||::|:.:||:.|||.:|:..:
Frog   843 LSRIIEDDPDAVYTTTGG---KIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDM 904

  Fly   345 TGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYDQLPDM--KPEQLKAV 407
            :...:::||: ..| ||..|..||:..:.||:.|||.:..:||:|.:|...|..|  .|..||..
Frog   905 SNQDVIKAIE-EGY-RLPAPMDCPAGLHQLMLDCWQKERGERPKFEQIVGILDKMIRNPNSLKTP 967

  Fly   408 V-NCTEPKKDHLLYRQGDIISVLDRNT 433
            : .|..|..           .:||:||
Frog   968 MGTCNRPTS-----------PLLDQNT 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	110/305 (36%)
		PTKc_Ack_like	137..398	CDD:270636	110/303 (36%)
		SH3	400..454	CDD:214620	9/35 (26%)
		CRIB	486..525	CDD:238077
epha7	XP_031758138.1	EphR_LBD_A7	29..205	CDD:198453
		Ephrin_rec_like	274..311	CDD:400166
		FN3	331..420	CDD:214495
		FN3	468..559	CDD:238020
		EphA2_TM	585..650	CDD:405290	0/1 (0%)
		PTKc_EphR_A	648..958	CDD:270651	112/314 (36%)
		SAM_EPH-A7	983..1052	CDD:188947	1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910