DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and epha4

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	XP_012825631.1	Gene:	epha4 / 100216124	XenbaseID:	XB-GENE-1015803	Length:	986	Species:	Xenopus tropicalis

Alignment Length:	384	Identity:	131/384 - (34%)
Similarity:	189/384 - (49%)	Gaps:	47/384 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 IPADSISVNKQLGTGEFGIVQQG-VWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHE 191
            |.|..|.:.|.:|.||||.|..| :...|...|.||||.|..........:||.||:||...:|.
Frog   615 IDASCIKIEKVIGVGEFGEVCSGRLKVPGKREIYVAIKTLKAGYTDKQRRDFLSEASIMGQFDHP 679

  Fly   192 NIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRL 256
            ||:.|.|||.....:|::||.....||...|:.:..|   .|:..|......|.:||:||.....
Frog   680 NIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGR---FTVIQLVGMLRGIGSGMKYLSDMSY 741

  Fly   257 IHRDLAARNILVFSKDKVKISDFGLSRALGVGKD-YYKTNFNVNLKLPIAWCAPECINYLRFTNA 320
            :|||||||||||.|....|:||||:||.|....: .|.|...   |:||.|.|||.|.|.:||:|
Frog   742 VHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGG---KIPIRWTAPEAIAYRKFTSA 803

  Fly   321 SDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAK 385
            ||||::|:.:||:.|||.:|:..::...:::||: ..| ||..|..||...:.||:.|||.:.:.
Frog   804 SDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIE-EGY-RLPPPMDCPIALHQLMLDCWQKERSD 866

  Fly   386 RPRFGEIYDQLPDM--KPEQLK------------AVVNCTEPKKDHLLYRQGDIISVLDRNTGTP 436
            ||:||:|...|..:  .|..||            |:::.:.|:       ...:.||||
Frog   867 RPKFGQIVSMLDKLIRNPNSLKRTGLDNSSRTNTALLDPSSPE-------WSQVASVLD------ 918

  Fly   437 FWKGVLSTGKTGYFNPSNTVA---FLEGLPSSTRDSFSRVSDHRISKRKLRTEMISKPQ 492
             |   |...|...:..:.|.|   .||.:....:|..:|:.   ||....:.:::|..|
Frog   919 -W---LQAIKMERYKDNFTAAGYTSLEAVVHVNQDDLTRIG---ISSPSHQNKILSSVQ 970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	106/264 (40%)
		PTKc_Ack_like	137..398	CDD:270636	106/262 (40%)
		SH3	400..454	CDD:214620	12/65 (18%)
		CRIB	486..525	CDD:238077	2/7 (29%)
epha4	XP_012825631.1	EphR_LBD_A4	30..203	CDD:198450
		FN3	329..435	CDD:238020
		FN3	440..531	CDD:238020
		EphA2_TM	551..615	CDD:373140	131/384 (34%)
		PTKc_EphR_A	615..881	CDD:270651	109/273 (40%)
		SAM_EPH-A4	911..981	CDD:188944	17/73 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910