DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and btk

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_001123732.1	Gene:	btk / 100170477	XenbaseID:	XB-GENE-6451230	Length:	649	Species:	Xenopus tropicalis

Alignment Length:	385	Identity:	121/385 - (31%)
Similarity:	187/385 - (48%)	Gaps:	62/385 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 KFYEKHFPHSYLSKIKRLLQAPGTMVKREEAPGGGSQVALDGSSAS--------ACSS------L 109
            ::|.|:...|...|:.|.....|..:.|:.:..|...|::...|:.        .|.:      |
Frog   273 EWYSKNMTRSQAEKLLRAEDKEGGFIVRDSSKAGKYTVSVYAKSSGEGIIRHYVVCEAPGNQYYL 337

  Fly   110 AAKNGASS-PSKVPNNKH--------------------------------IIPADSISVNKQLGT 141
            |.|:..|| |..:..::|                                |.|.| ::..|:||.
Frog   338 AEKHLYSSIPELITYHQHNAAGLISRLKYPVCSLRKTAPSTAGLGYGSWEIDPKD-LTFLKELGN 401

  Fly   142 GEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHENIVRLYGVVLATDSL 206
            |:||:|:.|.|...::   ||||.:....|..:  ||::||..|..:.|:|:|:||||......:
Frog   402 GQFGVVKYGKWRGQHD---VAIKMIKEGSMSED--EFIEEAKCMMKLSHQNLVQLYGVCTKQRPI 461

  Fly   207 MLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSK 271
            .::||......||..|||...|||...:.::|.   .:|..|.|||.|:.:||||||||.||.:.
Frog   462 FIITEFLSNGCLLNYLKDLRGRVSQGDLLSMCS---DVCAAMTYLESKQYLHRDLAARNCLVAAD 523

  Fly   272 DKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVCLWEMFSY 336
            ..||:|||||||.  |..|.|.:  ::..|.|:.|.:||.:.|.||::.||||:|||.:||:|:.
Frog   524 GIVKVSDFGLSRY--VLDDEYTS--SLGSKFPVRWSSPEVLLYCRFSSKSDVWSFGVLMWEVFTL 584

  Fly   337 GFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYDQL 396
            |..|:...|..:|:|.|  ....||.:|.......|::|:.||.:.|..||.|..:::.:
Frog   585 GRMPYDRFTNNEIVEQI--TRGVRLYRPQNATDRVYSIMVSCWAEKADDRPTFRILHNTI 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	2/5 (40%)
		STYKc	133..396	CDD:214568	100/262 (38%)
		PTKc_Ack_like	137..398	CDD:270636	100/260 (38%)
		SH3	400..454	CDD:214620
		CRIB	486..525	CDD:238077
btk	NP_001123732.1	PH_Btk	8..167	CDD:269944
		SH3_BTK	209..264	CDD:212839
		SH2_Tec_Btk	267..370	CDD:198260	18/96 (19%)
		PKc_like	388..638	CDD:419665	103/264 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910