DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ack-like and tnk2a

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	XP_009295758.2	Gene:	tnk2a / 100148041	ZFINID:	ZDB-GENE-091118-85	Length:	1082	Species:	Danio rerio

Alignment Length:	1302	Identity:	323/1302 - (24%)
Similarity:	485/1302 - (37%)	Gaps:	373/1302 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LYEFLTESELQQYYNAVKNELKITNAAQFKYAADEDLRFIGLSRPEIRRLRKFYEKHFP----HS 68
            |.|.||:.:||||:..:::||.:|..:.|.|...|||..||:.||..|||.:..::...    .|
Zfish    28 LLELLTDVQLQQYFQRIRDELNVTRLSHFDYVKTEDLEKIGMGRPGQRRLWEAVKRRRAMCKRKS 92

  Fly    69 YLSKIKRLLQAPGTMVKREEAPGGGSQVALDGSSASACSSLAAKNGASSPSKVPNNKH------I 127
            ::||...|                |.|| ..|....:.|.......:||||..|.:..      :
Zfish    93 WMSKSLCL----------------GQQV-FTGKRPDSDSQTPEVFRSSSPSSAPPDGQPTDLTCL 140

  Fly   128 IPADSISVNKQLGTGEFGIVQQGVWSNGNERI-QVAIKCLCRERMQSNP--MEFLKEAAIMHSIE 189
            |....:::.::||.|.||:|::|.|...:.|: .||:|||..:.:....  .:|::|...|||:.
Zfish   141 ISERDLTLYEKLGDGSFGVVKRGEWQAPSGRVLSVAVKCLKTDLLDQGEGLDDFIREVNAMHSLN 205

  Fly   190 HENIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQK 254
            |.|::||||.|| |..:.:|||||.|.|||:.|:.   |...:.|..||.:.:||..||.|||.:
Zfish   206 HHNLIRLYGCVL-THPMKMVTELAPLGSLLDRLRK---RQGHILISVLCHYTVQIACGMAYLESR 266

  Fly   255 RLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTN 319
            |.|||||||||||:.|.|.:||.||||.|||....|:|.  ...:.|:|.||||||.:....|::
Zfish   267 RFIHRDLAARNILLASNDLIKIGDFGLMRALPKNDDHYV--MQEHHKVPFAWCAPESLKTRTFSH 329

  Fly   320 ASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAA 384
            |||.|.|||.|||||::|.:||..|.|.|||..||... :||.:|:.||.:.|.:|::||.....
Zfish   330 ASDTWMFGVTLWEMFTHGQEPWVGLNGSQILHKIDREG-ERLIKPEDCPQDIYNVMLQCWSPKPE 393

  Fly   385 KRPRFGEIYDQLPDMKPEQLKAVVNCTEPKKDHLLYRQGDIISVLDRNTGTPFWKGV-LSTGKTG 448
            .||.|..:.|.|.:..|..::|:.:..||  |.|.....|||::::......:|:|. ..|.|.|
Zfish   394 DRPTFVSLRDFLVETMPTDMRALQDFDEP--DKLKIHANDIITIIEGRAENYWWRGQNRQTMKVG 456

  Fly   449 YFNPSNTVAFLEGLPSSTRDSFSRVSDHRISKRKLRTEMISKP-QNDFKHTGHVGID-GATFG-- 509
            .| |.|.|..:.||  |.:|                   ||:| ::.|.||||...| ..::|
Zfish   457 QF-PRNVVTSVAGL--SAQD-------------------ISRPLKHSFIHTGHGDTDPHRSWGAP 499

  Fly   510 ---DIAFLGSSQNYNHVPKQIV-------TPYKPSEDIEQTPLLLPPTPTSPDSLQTASGYFPEG 564
               |..:||:..:    |..::       .|.|.....::.|   ||.|..|..|
Zfish   500 DKIDDLYLGNPMD----PPDVLGLDSNTAKPTKLPNRAKKQP---PPRPPKPAVL---------- 547

  Fly   565 ANSGGAMGTSMNPTFIPSAEHTPKLIATNGQSSFDFASGSTNPFFPNRGDDELEFGLHNYGADGK 629
                                                   ...||:.:..||:.:..|...|....
Zfish   548 ---------------------------------------LKKPFYDSVLDDDDDDDLIVTGVKKL 573

  Fly   630 SVHSET-------GWRPTSR-------SIVD---------DPHEYHEISDDEIAADKLDFGPSLL 671
            |:.:.|       .|..||.       |::|         .|....||.:...|...|.:..|:|
Zfish   574 SLKTPTYLGLRLRPWESTSPSDRLCEVSLIDFGDDSFSSTSPSPITEIPNPSTAKPPLSYAASIL 638

  Fly   672 DEINSMFGSISAATGSHPKS------------PGFDHV------NNKNEITEMSAKLGQK----- 713
            |.......:.:.....||..            |.:|.|      ....|::.::|...|:
Zfish   639 DMAPPQSPNQALPNPMHPTPVVDWDMRPLPPLPAYDEVAIECAEQEDIEVSSINASAAQEDAVYE 703

  Fly   714 --------SGDTNGNKHGHGLLPTLSKKKSSGTVKPISVKDEKILNHAIEIANEISARSMIDLVS 770
                    :.|...|...:..||:...::|..            .:.:.:|..|:....|:.|
Zfish   704 QTPSEEDINNDGKRNVEDNLFLPSKRPEESHS------------FSQSADIFKELQREVMVKL-- 754

  Fly   771 DQTPVIHSPKRKFSFRFPHLSNNGSGDKSGGLGTSGSAHTPTHGN---ASPFPKKKNFTEELQSI 832
                                                  ..|..|.   :||.|.....|...|.|
Zfish   755 --------------------------------------RVPPSGRSLPSSPLPTPSVLTPHRQII 781

  Fly   833 PDIQRFRSLSEIKNSTDLRVPIFDKESSDFLFQKSREILSRPLNL---ERECGDEQPPKSIDDNI 894
                 ..|..|.|.....|:||.....|     |...|....|::   |.|.|...||:     |
Zfish   782 -----LPSSYEDKPQIPPRIPIPPMRPS-----KRTGIYGSRLSVSLGENEDGSRCPPQ-----I 831

  Fly   895 MDIENTLKALNLDFMHTYTELDKSDSNDTILNDQLPHMASLDDGIS-SATGSLKSAV--YSYSNG 956
            ...::.|                |..|....:..:|...|.....| ...|||.|.:  .|||
Zfish   832 PPRDHAL----------------SQPNSRAPSPMVPQSGSPQQRSSLCCVGSLGSCLSPSSYS-- 878

  Fly   957 VQTMFDFNAATSHLDKHLQYMHNQAQLSAAAPVDPKPMDDKRSSTPDTGFASRDTNISLSRRSSQ 1021
                                         :||          ||:..|...|..|:
Zfish   879 -----------------------------SAP----------SSSSTTSSTSTTTS--------- 895

  Fly  1022 KSSYSPQESFHFPLKGEPLFSAPPVVMSGGYAS------LKDELG----YERF----GNGATKQM 1072
             |.|...|....|.|...:.   |:|..|..||      |.::..    ||:|    ||...:..
Zfish   896 -SQYGSTEVSQNPAKSPCIL---PIVHGGVKASSTHYYLLPEKPAYLDKYEKFFNSEGNDEKRTT 956

  Fly  1073 -LASASPIKSGVGLNASSGSVYMGSKGYRQR----STSFNESFHPISPVLSEPPQRERGV----- 1127
             :|:..|:....|..:::...:..:.|....    |:|...|:..::  |.:..:...||
Zfish   957 NMATVRPMVQQQGNKSNASPSHTSNSGTSSSLAWPSSSQAGSYSRVT--LQQVQEAVHGVTVEEC 1019

  Fly  1128 ----------IQRQVRLEQQQPLPRRSASYKPRSIRARTLRRLSYNPMTLDSSSSSGEEPVKPSL 1182
                      .|..|:..:.:.|.|.....:|..:  .||:|..:|   |:.:|:...:...||.
Zfish  1020 QTALQAHNWNAQEAVKYLKVEQLFRLGLKTRPECM--ETLQRCGWN---LEQASTQMLDSYGPSR 1079

  Fly  1183 AR 1184
            .|
Zfish  1080 HR 1081

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	23/56 (41%)
		STYKc	133..396	CDD:214568	118/265 (45%)
		PTKc_Ack_like	137..398	CDD:270636	119/263 (45%)
		SH3	400..454	CDD:214620	16/54 (30%)
		CRIB	486..525	CDD:238077	13/45 (29%)
tnk2a	XP_009295758.2	SAM_TNK-like	24..85	CDD:188938	23/56 (41%)
		PTKc_Ack_like	150..407	CDD:270636	119/263 (45%)
		SH3	413..464	CDD:214620	16/53 (30%)
		GTPase_binding	467..533	CDD:312537	20/90 (22%)
		Inhibitor_Mig-6	828..>867	CDD:314449	9/59 (15%)
		UBA_ACK1	1006..1046	CDD:270460	6/39 (15%)
		UBA_TNK1	1033..1072	CDD:270513	10/43 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0199
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D426644at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820