DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and prmt5

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	XP_002941557.1	Gene:	prmt5 / 100145788	XenbaseID:	XB-GENE-975034	Length:	633	Species:	Xenopus tropicalis

Alignment Length:	230	Identity:	45/230 - (19%)
Similarity:	77/230 - (33%)	Gaps:	79/230 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   331 WEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYDQ 395
            :|||:.|::.:.......:::.:::..|:..|:.....|:|...:.||             :.|:
Frog   293 YEMFAKGYEDYLQSPLQPLMDNLESQTYEVFEKDPVKYSQYQQAVYKC-------------LLDR 344

  Fly   396 LPDMKPEQLKAVVNCTEPKKDHLLYRQGDIISVLDRNTGTPFWKGVLSTGKTG------YF---N 451
            :|:             |.|:.::     .::.||....| |.....|...|..      |.   |
Frog   345 VPE-------------EEKETNI-----QVLMVLGAGRG-PLVNASLRAAKQAERKIKVYAVEKN 390

  Fly   452 PSNTVAFLEG----------------------------LPSSTRDSFSRVSDHRISKRKLRTEMI 488
            | |.|..|||                            :.|....||   .|:.:|     .|.:
Frog   391 P-NAVITLEGWRYEEWGSQVTVVSGDMREWKAPEKADIIVSELLGSF---GDNELS-----PECL 446

  Fly   489 SKPQNDFKHTGHVGIDGATFGDIAFLGSSQNYNHV 523
            ...|:..|..| |.|.......:|.:.||:.||.|
Frog   447 DGAQHFLKEDG-VSIPSEYTSYLAPISSSKLYNEV 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	11/64 (17%)
		PTKc_Ack_like	137..398	CDD:270636	11/66 (17%)
		SH3	400..454	CDD:214620	11/62 (18%)
		CRIB	486..525	CDD:238077	12/38 (32%)
prmt5	XP_002941557.1	PRMT5_TIM	32..286	CDD:375105
		PRMT5	291..460	CDD:368326	38/208 (18%)
		PRMT5_C	464..631	CDD:375106	6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0199
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900