DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ack-like and tnk2

DIOPT Version :9

Sequence 1:NP_001260935.1 Gene:Ack-like / 36442 FlyBaseID:FBgn0263998 Length:1495 Species:Drosophila melanogaster
Sequence 2:XP_031757304.1 Gene:tnk2 / 100124754 XenbaseID:XB-GENE-984470 Length:1151 Species:Xenopus tropicalis


Alignment Length:1328 Identity:338/1328 - (25%)
Similarity:509/1328 - (38%) Gaps:407/1328 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 LYEFLTESELQQYYNAVKNELKITNAAQFKYAADEDLRFIGLSRPEIRRL------RKFYEKHFP 66
            |.|.|:|.:||||:..::::|.||..:.|.|..:|||..||:.||..|||      ||...|.  
 Frog    38 LLELLSEVQLQQYFLQIRDDLNITRLSHFDYVKNEDLEKIGMGRPGQRRLLDAVKRRKAICKR-- 100

  Fly    67 HSYLSKI---KR----LLQAPGTMVKREEAPGGGSQVALDGSSASACSSLAAKNGASSPSKVPNN 124
            .|::||:   ||    ....|.:..::..:|     ..|:|..|..|                  
 Frog   101 KSWMSKVFSGKRPESEFASQPQSTFRKPPSP-----PPLEGQQALTC------------------ 142

  Fly   125 KHIIPADSISVNKQLGTGEFGIVQQGVWSNGNERI-QVAIKCLCRERMQSNPM--EFLKEAAIMH 186
              :|....:|:.::||.|.||:|::|.|:..|.:: .||:|||..:.:....:  :|::|...||
 Frog   143 --LISEKDLSMFEKLGDGSFGVVRRGEWNTPNGKLFNVAVKCLKTDVLTQPDVLDDFIREVNAMH 205

  Fly   187 SIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECL-KDSGLRVSFLTIPTLCEFALQICNGMRY 250
            |::|.|::||||||| |..:.:|||||.:.|||:.| |:.|    :..|.|||.:|:||.|||.|
 Frog   206 SLDHINLIRLYGVVL-THPMKMVTELAPMGSLLDRLRKNQG----YFLISTLCHYAIQIANGMAY 265

  Fly   251 LEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYL 315
            ||.||.|||||||||||:.|.|.|||.||||.|||....|:|.  ...:.|:|.||||||.:...
 Frog   266 LESKRFIHRDLAARNILLSSNDLVKIGDFGLMRALPKNDDHYV--MQEHRKVPFAWCAPESLKTR 328

  Fly   316 RFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQ 380
            .|::|||.|.|||.|||||:||.:||..|.|.|||..||... :||.:|:..|.:.|.:|::||.
 Frog   329 TFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEG-ERLVRPEDSPQDIYNVMLQCWA 392

  Fly   381 DDAAKRPRFGEIYDQLPDMKPEQLKAVVNCTEPKKDHLLYRQGDIISVLDRNTGTPFWKGV-LST 444
            .....||.|..:.|.|.:.:|..:.|:.:..:|.|.|:  :..|:|:|::......:|:|. ..|
 Frog   393 HKPEDRPTFVALRDFLVEAQPTDMCALQDFQDPDKLHI--QMNDVITVIEGRAENYWWRGQNKRT 455

  Fly   445 GKTGYFNPSNTVAFLEGLPSSTRDSFSRVSDHRISKRKLRTEMISKP-QNDFKHTGHVGIDGATF 508
            .|.|.|. .|||..:.||  |..|                   ||:| :|.|.||||        
 Frog   456 LKVGQFQ-RNTVTSVAGL--SAHD-------------------ISRPLKNSFIHTGH-------- 490

  Fly   509 GDIAFLGSSQNYNHVPKQIVTPYKPSEDIEQTPLLLPPTPTSPDSLQTASGYFPEGANSGGAMGT 573
            ||.           ||...   :...:.|::..|..|..|  ||.|         |.:.|.|   
 Frog   491 GDT-----------VPAHC---WGFPDRIDELYLGNPMDP--PDIL---------GLDQGTA--- 527

  Fly   574 SMNPTFIPSAEH-----TPKLIATNGQSSFD-------------------FASGSTNPFFPNRGD 614
              .||.:||...     .|...|...:|.|.                   |...|.|..  |..|
 Frog   528 --RPTQLPSRAKREPPPRPPQPAARVKSKFHGTILRAPCSCPLCAIIVPLFQEPSYNTV--NGED 588

  Fly   615 DELEFGLHNY------GADG----KSVHSETGWRPTSRSIVDDPHEYHEISDDEIAADKLDFGPS 669
            |.:..|:...      .|.|    |.....||.:.|.|.:.|  ...:.:.::|:    :|||..
 Frog   589 DSITLGIKKLYLKKPTPAKGLKLVKPSARVTGTKVTDRQLSD--IRSNSLKEEEL----IDFGED 647

  Fly   670 LLDEINSMFGSISAATGSHPKSPGFDHVNNKNEITEMSAKLGQKSGDTNGNKHGHGLLPTLSKKK 734
            |                 .|.|||:           :|..:.|.:             |:|:|  
 Frog   648 L-----------------SPISPGY-----------LSPAVEQTA-------------PSLAK-- 669

  Fly   735 SSGTVKPISVKDEKILNHAIEIANEISARSMIDLVSDQTPVIHSPKRKFSFRFPHLSNNGSGDKS 799
                                 :|.|  |.|::|....|:|                         
 Frog   670 ---------------------LAME--AFSLLDKTPPQSP------------------------- 686

  Fly   800 GGLGTSGSAHTPTH------GNASPFPKKKNFTEELQSIPDIQRFRSLSEIKNSTDLRVPIFDKE 858
                 |.|...|.|      .::.|.|....:.|..|...|.:                 :....
 Frog   687 -----SRSLPRPLHPTPVVDWDSKPLPAPPAYDEVAQDEDDFE-----------------VCSIN 729

  Fly   859 SSDFLFQKSREILSRPLNLERECGD------EQPPK-----SIDDNIMDIENTLKALNLDFMHTY 912
            |||.|..:..::....|...||.|:      ::..:     .::||:.......|..:|      
 Frog   730 SSDVLLAQKEKVTVNLLQRAREKGETNYGYVKEEERYNCRGKLEDNLFLPPKDTKQPSL------ 788

  Fly   913 TELDKSDSNDTILNDQLPHMASLDDGISSATGSLKSAVYSYSNGVQTMFDFNAATSHLDKHLQYM 977
                 |.:::.....|...|..|:...|::..|..|                .:||.:..::...
 Frog   789 -----SQTSEIFEELQQECMKRLNVPASTSLASTPS----------------PSTSIMHINVTPS 832

  Fly   978 HNQAQLSAAAPVDPKPMDDKRSSTPDTGFASRDTNISLSRRSSQKSSYSPQESFHFPLKGEPLFS 1042
            .::.|:....|:.|:|:                       |.::...:|.:.|   |..|.....
 Frog   833 EDKPQIPPRIPIPPRPV-----------------------RRNEHDRWSGELS---PAFGADEIG 871

  Fly  1043 APPVVMSGGYASLKDELGYE--------RFGNGATKQMLASASPIKSGVGLNASSGSVYMGSKGY 1099
            .||::..      :|.|...        .|..|:.:|.....||:..|..|:.|.|.:...::.:
 Frog   872 RPPLLPP------RDPLSQPTSRTPSPMAFQVGSPQQRSNLCSPLSIGTYLSTSPGKLMPTTQSF 930

  Fly  1100 RQRSTSFNESFHPISPVLSEPPQRERGVIQRQVRLEQQQP--LPRRSASYKPRSIRARTL-RRLS 1161
                             .|:|......|||.|.:...:.|  ||......|..|.....| .|.|
 Frog   931 -----------------ASDPKYATPKVIQAQGKDHVKGPCILPIVKDGKKVSSTHYYLLPERPS 978

  Fly  1162 YNPMTLDSSS---SSGEEPVKPSLARS-----------ECDIRARVAASSNSSLGRRRRAGMNRQ 1212
            |    ||...   ...:.|.:.|:.||           :.|.:|..  |||:|     .......
 Frog   979 Y----LDKYEKFFKEAQSPEESSVVRSITTATVRPMVHQTDYKANF--SSNNS-----NCSSKST 1032

  Fly  1213 VQSACHDEREVIISPRQMYGSNSSIKSA 1240
            |:::|..::.|       |.....||:|
 Frog  1033 VKTSCSLQKIV-------YDGPDCIKNA 1053

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ack-likeNP_001260935.1 SAM_TNK-like 4..65 CDD:188938 26/62 (42%)
STYKc 133..396 CDD:214568 125/266 (47%)
PTKc_Ack_like 137..398 CDD:270636 125/264 (47%)
SH3 400..454 CDD:214620 14/54 (26%)
CRIB 486..525 CDD:238077 12/39 (31%)
tnk2XP_031757304.1 SAM_TNK-like 34..95 CDD:188938 23/56 (41%)
PTKc_Ack_like 153..410 CDD:270636 125/264 (47%)
SH3_9 418..467 CDD:405311 15/51 (29%)
GTPase_binding 472..533 CDD:401099 28/119 (24%)
Inhibitor_Mig-6 883..947 CDD:402933 15/80 (19%)
UBA_ACK1 1074..1115 CDD:270460
UBA_TNK1 1102..1141 CDD:270513
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D426644at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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