DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ack-like and erbb4a

DIOPT Version :9

Sequence 1:NP_001260935.1 Gene:Ack-like / 36442 FlyBaseID:FBgn0263998 Length:1495 Species:Drosophila melanogaster
Sequence 2:NP_001137223.1 Gene:erbb4a / 100007677 ZFINID:ZDB-GENE-030918-4 Length:1414 Species:Danio rerio


Alignment Length:769 Identity:199/769 - (25%)
Similarity:313/769 - (40%) Gaps:157/769 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   117 SPSKVPNNK---HIIPADSISVNKQLGTGEFGIVQQGVWSNGNE--RIQVAIKCLCRERMQSNPM 176
            :||....|:   .|:....:...|.||.|.||:|..|:|....|  :|.||||.|.........:
Zfish   688 TPSGAAPNQAQLRILKETELKRVKILGAGAFGMVYXGIWVPEGETVKIPVAIKILNESTGPKANV 752

  Fly   177 EFLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFA 241
            ||:.||.||.|:||.::|||.||.| :.::.|||:|.....||:.:.:....:....:...|   
Zfish   753 EFMDEALIMASMEHPHLVRLLGVCL-SPTIQLVTQLMPHGCLLDYVHEHQDNIGSQLLLNWC--- 813

  Fly   242 LQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAW 306
            :||..||..||::||:||.|||||:||.|.:.:||:||||:|.|...:..|.::..   |:||.|
Zfish   814 VQIAKGMMXLEERRLVHRXLAARNVLVKSPNHIKITDFGLARLLDTDEKEYNSDGG---KMPIKW 875

  Fly   307 CAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEY 371
            .|.|||:|.:||:.||||::||.:||:.::|..|:..:....|.:.::  ..:||.||..|..:.
Zfish   876 MALECIHYRKFTHQSDVWSYGVTIWELMTFGGXPYDGIPTRDIPDILE--KGERLPQPPICTIDV 938

  Fly   372 YTLMMKCWQDDAAKRPRFGEIYDQLPDMKPEQLKAVV-----NCTEPKKDHLLYRQGDIISVLDR 431
            |.:|:|||..||..||||.|:..:...|..:..:.:|     ....|..:|..:.|    |:||.
Zfish   939 YMVMVKCWMIDADSRPRFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNHSTFFQ----SLLDE 999

  Fly   432 --------------------NTGTPFWKGVLSTGKT-----GYFNPSNTV-AFLEGLPSSTRDSF 470
                                :|.|...:..:....|     ..|:|.:.: |....:|:|....|
Zfish  1000 EELDDLMDADEYLVPQTCNISTSTYTSRTTMDASWTLRCRDRVFSPEDGMGACSRDVPASASAVF 1064

  Fly   471 SRVSDHRISKRKLRTEMIS---KPQNDFKHTGHVGIDGATFG--DIAFLGSSQNYNHVPKQIVTP 530
            ..||........|..:..:   |.|.....:|. ..||..:.  ...|||.....|......::|
Zfish  1065 VPVSTQAAGLNVLEEQHCNGSLKKQQPMSGSGD-DCDGQRYSADPTVFLGERSLKNTDEDGYMSP 1128

  Fly   531 YKPS-----EDIEQTPLL------------LPPTPTSPDSLQTA--SGYFPE-----GANSGGAM 571
            ...|     ..:|:.|.:            .|...::||....|  ..|..|     ..|:.|  
Zfish  1129 MNKSTSDHLSPVEENPFVNHRKNGNITALDNPGYHSTPDRKSKAEEDEYINEPLYLNAYNTTG-- 1191

  Fly   572 GTSM-----NPTFIPSAEHTPKLIATNGQSSFDFASGSTNPFFPNRGDDELEFGLHNYGADGKSV 631
            ||::     |.:.||....|    ||:..||....  ||.|            |..::...|..|
Zfish  1192 GTNLEIMRRNGSSIPLQMTT----ATSAASSHIIL--STQP------------GKAHHHGQGTHV 1238

  Fly   632 H--------------SETGWRPTSRSIVDDPHEYHEISDDEIAADKLDFGPSLLDEINSMFGSIS 682
            |              |:.|....|...|            |..:..:...||||.:|:.:...|.
Zfish  1239 HFAIPPVQPPQTRAMSQNGQHSQSSHAV------------ESNSSSMSANPSLLSQISLVSQQIQ 1291

  Fly   683 AATGSH---PKS----------PG-----FDHVNNKNEITEMSAKLGQKSGDTNGNKHGHGLLPT 729
            ....|.   |||          ||     .:.:...:..|.|:.:..:|:.| |.:...|.|.|.
Zfish  1292 PCLASQSQVPKSTVPNKSISGLPGHLVYPVNMLQTGHTGTVMADRKSKKNFD-NPDYWQHSLPPK 1355

  Fly   730 LSKKKSSGTVKPISVKDEKILNHAIEIANEISARSMIDLVSD----QTPVIHSP 779
            :::.......:  :.|.:.:..|:|.  :.::.....:.||:    ..||:..|
Zfish  1356 VTQANPQDPTQ--TCKSKHLYRHSIR--SRLAVADNPEFVSEFNKRPGPVLPPP 1405

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ack-likeNP_001260935.1 SAM_TNK-like 4..65 CDD:188938
STYKc 133..396 CDD:214568 104/264 (39%)
PTKc_Ack_like 137..398 CDD:270636 104/262 (40%)
SH3 400..454 CDD:214620 12/83 (14%)
CRIB 486..525 CDD:238077 9/43 (21%)
erbb4aNP_001137223.1 Recep_L_domain 54..166 CDD:279382
FU 182..216 CDD:214589
Furin-like 184..331 CDD:279142
FU 228..273 CDD:238021
Recep_L_domain 357..477 CDD:279382
GF_recep_IV 501..632 CDD:291509
FU 502..552 CDD:238021
FU 548..595 CDD:214589
TM_ErbB4 631..674 CDD:213053
PKc_like 699..995 CDD:304357 110/308 (36%)
Pkinase_Tyr 707..963 CDD:285015 104/264 (39%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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