Protein Alignment Ack-like and abl1

DIOPT Version :9

• Sequence 1: NP_001260935.1
• Gene: Ack-like / 36442
• FlyBaseID: FBgn0263998
• Length: 1495
• Species: Drosophila melanogaster
• Sequence 2: XP_005172104.1
• Gene: abl1 / 100000720
• ZFINID: ZDB-GENE-100812-9
• Length: 1081
• Species: Danio rerio
• Alignment Length: 1142
• Identity: 261/1142 - (22%)
• Similarity: 408/1142 - (35%)
• Gaps: 327/1142 - (28%)

  Fly     6 IDLYEFLTESELQQYYNAVKNELKITNAAQFKYAADEDLRFIGLSR------------------- 51
            :.||:|:...:         |.|.||..        |.||.:|.:.
Zfish    81 VALYDFVASGD---------NTLSITKG--------EKLRVLGYNHNGEWCEAQTKNGQGWVPSN 128

  Fly    52 --PEIRRLRKFYEKHFPHSYLSKIKRLLQA--PGTMVKR--EEAPGGGS--------------QV 96
              ..:..|.|....|.|.| .:..:.||.:  .|:.:.|  |.:||..|              ..
Zfish   129 YITPVNSLEKHSWYHGPVS-RNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINT 192

  Fly    97 ALDG----SSASACSSLA----------------------AKNGASSPSKVPN-NKHIIPADSIS 134
            |.||    ||.|..::||                      .:|..:.....|| :|..:....|:
Zfish   193 ASDGKLYVSSESRFNTLAELVHHHSTVSDGLITTLHYPAPKRNKPTIYGVSPNYDKWEMERTDIT 257

  Fly   135 VNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHENIVRLYGV 199
            :..:||.|::|.|.:|||...:  :.||:|.|..:.|:..  |||||||:|..|:|.|:|:|.||
Zfish   258 MKHKLGGGQYGEVYEGVWKKYS--LTVAVKTLKEDTMEVE--EFLKEAAVMKEIKHPNLVQLLGV 318

  Fly   200 VLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAAR 264
            ........::||.....:||:.|::...:.  :....|...|.||.:.|.|||:|..||||||||
Zfish   319 CTREPPFYIITEFMTHGNLLDYLRECNRQE--VNAVVLLYMATQISSAMEYLEKKNFIHRDLAAR 381

  Fly   265 NILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVC 329
            |.||...:.||::|||||| |..|..|   ..:...|.||.|.|||.:.|.:|:..||||||||.
Zfish   382 NCLVGENNLVKVADFGLSR-LMTGDTY---TAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVL 442

  Fly   330 LWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYD 394
            |||:.:||..|:..:...|:.|.:: .:| |:::|:.||.:.|.||..||:.:.|:||.|.|.:.
Zfish   443 LWEIATYGMSPYPGIDLSQVYELLE-KDY-RMDRPEGCPEKVYELMRACWRWNPAERPSFAETHQ 505

  Fly   395 QLPDMKPEQLKAVVNCTEPKKDHLLYRQGDIISVLDRNTGTPFWKGVLSTGKTGYFNPSNTVAFL 459
            ....|                    :::..|...:::..|        ..||.....|   :...
Zfish   506 AFETM--------------------FQESSISDEVEKELG--------KKGKKLTLGP---IQQA 539

  Fly   460 EGLPSSTRDSFSRVSDHRISKRKLRTEMISKPQNDFKHTGHVGIDGATFGDIAFLGSS------- 517
            ..||:.|| :..|.:|.|              ..|........:.|........|.|:
Zfish   540 PELPTKTR-TLRRPTDGR--------------DGDSPDAAEAEVTGPPMMPRPLLDSNLNEDDRL 589

  Fly   518 QNYNHVPKQIVTPYKPSEDIEQTPLLLPPTPTSPDSLQTASGY-------------FPEGANSGG 569
            |:.::..|..:.|:...:..::|   .|..|....|.....|:             |..|:::..
Zfish   590 QSKDNKDKFRMNPFSYIKKKKRT---APAPPKRSSSFGKMDGHLDRRGLGTDCREDFSNGSSTND 651

  Fly   570 AMGTSMNPTFIPSAEHTPKLIATNGQSSFDFASGSTNPFFPNRGDDELEFGLH------NYGADG 628
            |: .|::|.         ||:.:|..::....:|:  |.:|.:     .|..|      ..|..|
Zfish   652 AL-NSIDPC---------KLVGSNSTTTIGVTNGA--PVYPGQ-----LFPSHPRKKGTTSGGGG 699

  Fly   629 KSVHSETGWRPTSRSIVDDPHEYHEISDDEIAADKLDFGPSLLDEINSMFGSISAATGSHPKSPG 693
            |..             ...|.|...:|                   ||.....|:::.|.|  ||
Zfish   700 KLA-------------TTPPPEEDSMS-------------------NSKRFLRSSSSSSMP--PG 730

  Fly   694 FDHVNNKNEITEMSAKLGQKSGDTNGNKHGHGLLPTLSKKKSSGTVKP---ISVKDEKILNHAIE 755
            .|....|:  ..:...:.....|:| ...|...||..|.....||:.|   :..|.|.:.:...:
Zfish   731 SDRFEWKS--VTLPRDIQSTHFDSN-TFRGKPALPRKSCMPRGGTLTPPPRLPKKSEDVSDEVFK 792

  Fly   756 IANEISARSMIDLV----------SDQTPVIHSPKRKFSFRFPHLSNNGSGDKSGGLGTSGSAHT 810
            .:......|.:.|.          |.:|..:.:...|.:...|             ||..|.
Zfish   793 DSESSPGSSPLTLTPKLGRRPQTESSKTSALQTEVLKPNVLPP-------------LGDEGR--- 841

  Fly   811 PTHGNASPFPKKKNFTEELQSIPDIQRFRS---------------LSEIKNSTDLRVPIFDKESS 860
                     |::...:.|:..    ||.|.               :|..|:....|.|.|: .||
Zfish   842 ---------PRRLKLSSEIPG----QREREKGKFAKPKPAPPPPPVSSAKSGKTSRSPTFE-VSS 892

  Fly   861 DFLFQKSREILSR-PLNLERECGDEQPPKSIDDNIMDIENT--LKALN------------LDFMH 910
            |...:.|.:...: ..:|.:|...:.|......|......|  |..:.            :..|.
Zfish   893 DTKVKSSLDSADQGKASLSQESAKKLPKNGSKVNPSKAGATAPLPGMGASPVVGDPGSSFIPLMT 957

  Fly   911 TYTELDKSD--------SNDTILNDQLPHMASL----DDGISSATGS----------LKSAVYSY 953
            |...|.|:.        |:.||..|.|...:.|    ...:|..|||          |.....||
Zfish   958 TRRSLRKAPARQPSERLSSSTITRDMLLESSELLRTAIARVSEQTGSHSAVLEAGKNLSKYCVSY 1022

  Fly   954 SNGVQTM---FDFNAATSHLDKHLQYMHNQAQLSAAA 987
            ...:|.|   |.|..|.:.|:..|:    :.|:..||
Zfish  1023 VESIQQMRNKFAFREAINKLESSLR----ELQICPAA 1055

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	13/79 (16%)
		STYKc	133..396	CDD:214568	105/262 (40%)
		PTKc_Ack_like	137..398	CDD:270636	104/260 (40%)
		SH3	400..454	CDD:214620	5/53 (9%)
		CRIB	486..525	CDD:238077	5/45 (11%)
abl1	XP_005172104.1	SH3_Abl	79..132	CDD:212784	11/67 (16%)
		SH2_ABL	137..230	CDD:198189	20/93 (22%)
		PTKc_Abl	249..511	CDD:270645	106/293 (36%)
		Pkinase_Tyr	256..507	CDD:285015	105/262 (40%)
		FABD	958..1081	CDD:197885	26/102 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910