DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Blk and Src42A

DIOPT Version :9

Sequence 1:	XP_006252250.1	Gene:	Blk / 364403	RGDID:	1308859	Length:	554	Species:	Rattus norvegicus
Sequence 2:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster

Alignment Length:	575	Identity:	258/575 - (44%)
Similarity:	338/575 - (58%)	Gaps:	60/575 - (10%)

- Green bases have known domain annotations that are detailed below.

  Rat     5 CARS--YKTSSCDLRPLAEEVS-----TPKRLWRQLSWGRDSAESASMPCGLLRLFLRMGLLSSK 62
            |.|:  .|:||.|...|:..:|     :|.|..|.|...|...:....|            |:.|
  Fly  1050 CTRNALTKSSSLDAISLSVAISPASSPSPPRPRRSLKQHRCLQQHQQTP------------LAKK 1102

  Rat    63 RQISEKSKSWSPVKARAQGKVPPPLPPLVVFNHLPPPSPNQHPDEEERFVVALFDYAAVNDRDLQ 127
            ..:....:..|...:|         .||..:::..|.....||..||..:.|:     ...|.|.
  Fly  1103 HSLDNCLQVVSSTTSR---------QPLRRWSNQTPLKCTCHPATEELPLTAI-----EKSRSLP 1153

  Rat   128 VLKGEK-------LQVL---KSTGDWWLARSLVTGREGYVP--SNFVAPVETLEVEKWFFRTISR 180
            ......       |.|:   .:|...:...||.|.::|...  |.|... |.|..:.|:||.|.|
  Fly  1154 AACSASCSHTCAHLSVIDQSPATTKCFGKTSLTTAKKGKSRRLSEFTRG-EFLNEKSWYFRKIKR 1217

  Rat   181 KDAERQLLAPMNKAGSFLIRESESNKGAFSLSVKDVTSQGEMVKHYKIRSLDNGGYYISPRITFP 245
            .:||::||.|.|:.|:||||:|||....:||||:|    |:.||||:||.||.||::|:.|.||.
  Fly  1218 IEAEKKLLLPENEHGAFLIRDSESRHNDYSLSVRD----GDTVKHYRIRQLDEGGFFIARRTTFR 1278

  Rat   246 TLQALVQHYSEKGDGLCQKLTLPCV---NPAPK--NPWAQDEWEIPRQSLKLVRKLGSGQFGEVW 305
            |||.||:|||:..||||..|..|||   .|..:  :...:|:|||.|.|||.||||||||||:||
  Fly  1279 TLQELVEHYSKDSDGLCVNLCKPCVQIEKPVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVW 1343

  Rat   306 MGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKTLQHERLVRLYAVVT-REPIYIVTEYMARGCL 369
            .|.:.|...|||||||.|||.|:.||.||.:||.|:|.:|::||||.| .|||||:||.|..|.|
  Fly  1344 EGLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSL 1408

  Rat   370 LDFLK--TDEGSRLSLPRLIDMSAQVAEGMAYIERMNSIHRDLRAANILVSETLCCKIADFGLAR 432
            |::|:  ..:|..|.:..||||:||:|.||||:|..|.|||||.|.|:||.:....|||||||||
  Fly  1409 LEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLAR 1473

  Rat   433 II-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEIVTYGRVPYPGMSNPEVIRS 496
            :| :.||.|:.||:||||||||||.::..|:||:||||||:||.|:|||||:|||||:|.||:..
  Fly  1474 LIKEDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQ 1538

  Rat   497 LEHGYRMPCPETCPPELYHDVITECWRGRPEERPTFEFLQSVLEDFYTATEGQYE 551
            :|||||||.|..|.|.|| :::.|||...|..|||||.||..||||||:.:..|:
  Fly  1539 VEHGYRMPQPPNCEPRLY-EIMLECWHKDPMRRPTFETLQWKLEDFYTSDQSDYK 1592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Blk	XP_006252250.1	SH3	111..164	CDD:302595	12/64 (19%)
		SH2	169..268	CDD:301589	52/98 (53%)
		PKc_like	282..545	CDD:304357	160/266 (60%)
		Pkinase_Tyr	290..539	CDD:285015	150/252 (60%)
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	52/94 (55%)
		PTKc_Frk_like	1319..1587	CDD:270653	162/268 (60%)
		Pkinase_Tyr	1328..1580	CDD:285015	150/252 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920