DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cap-G and YCG1

DIOPT Version :9

Sequence 1:	NP_995827.2	Gene:	Cap-G / 36440	FlyBaseID:	FBgn0259876	Length:	1351	Species:	Drosophila melanogaster
Sequence 2:	NP_010612.2	Gene:	YCG1 / 851925	SGDID:	S000002733	Length:	1035	Species:	Saccharomyces cerevisiae

Alignment Length:	1174	Identity:	240/1174 - (20%)
Similarity:	445/1174 - (37%)	Gaps:	292/1174 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 IMRQAELKESLHKRY---SKEMQQLYAKMGHE-SFRKAFINVLKAVLGAEEGNENANMALNFCAT 118
            :.::|:...:.|:::   .|::|....:.|:| :|...|..::..:|..::.....:..:...|.
Yeast    20 VFQKAQGSYAGHRKHIAVLKKIQSKAVEQGYEDAFNFWFDKLVTKILPLKKNEIIGDRIVKLVAA 84

  Fly   119 FVTS----------------SDSDGTEPMLAETF--HWLLTTYSSNPHIRYRICYFVNLILKELG 165
            |:.|                :|.:|......:.|  |.|....|.:.::|:|:...:.:|:..:|
Yeast    85 FIASLERELILAKKQNYKLTNDEEGIFSRFVDQFIRHVLRGVESPDKNVRFRVLQLLAVIMDNIG 149

  Fly   166 PNAALDDHQCDDILEAMLDRVKDVSASVRKQAVLAMQRLQNPDNPSDVVVGAYMYHLT------- 223
               .:|:...:.::.::..|:.|...:||.|||..:.:.|:.:...         |||
Yeast   150 ---EIDESLFNLLILSLNKRIYDREPTVRIQAVFCLTKFQDEEQTE---------HLTELSDNEE 202

  Fly   224 -------------SDPSPNVRQCIITCMGRNYITIPHILERLWDVDEKVRRHTYVNM-------C 268
                         :|||..||:..:..:..:..|.|:||||..||:...||..|..:       |
Yeast   203 NFEATRTLVASIQNDPSAEVRRAAMLNLINDNNTRPYILERARDVNIVNRRLVYSRILKSMGRKC 267

  Fly   269 NYPVRSYKVAQRLTLLEQGLNDTSATVRKTVINFMLKTWIESYQQNYVALIAALKLDSNEEELLR 333
            ...:..:...|   |:|.||.|...:||......:...|:.:...:.:.|:.  |||.:...
Yeast   268 FDDIEPHIFDQ---LIEWGLEDRELSVRNACKRLIAHDWLNALDGDLIELLE--KLDVSRSS--- 324

  Fly   334 FRRVAKQMLRVIFQQTDIKQLIDQLPLSEDCELHRCIPHDSVTVEL-----LLYWQCL----SEY 389
               |..:.:..:||..  ..::.::...|..       ....|||:     .:|..||    :|.
Yeast   325 ---VCVKAIEALFQSR--PDILSKIKFPESI-------WKDFTVEIAFLFRAIYLYCLDNNITEM 377

  Fly   390 LETEAPEIESLLPELSVFCTYMDKFCQFQKPDMDKFAQVEFQ-NMLLSLVEIL----ETYDLGDE 449
            ||...||...|...|:.:.     ..::...|:...:|..|. |.|..::|.|    |.||..||
Yeast   378 LEENFPEASKLSEHLNHYI-----LLRYHHNDISNDSQSHFDYNTLEFIIEQLSIAAERYDYSDE 437

  Fly   450 IGRGNMRLLITNLLKDCLLDHKIVRVLVRCMEQLITDTNDRIQYFIEIIYELCELNTKQNDLIHD 514
            :||.:|..::.|:|....|...::::.:|.|:.|..:..|.:...||||          || |.|
Yeast   438 VGRRSMLTVVRNMLALTTLSEPLIKIGIRVMKSLSINEKDFVTMAIEII----------ND-IRD 491

  Fly   515 RSLINKLLDDLD-TPLKMKISSLKV---KILELEELEGNYVRQREYIRAQSVN-DEKIAVTEEYT 574
                    ||:: ...:.||.|.|:   ....::|.:.|.....|      || ||:......:.
Yeast   492 --------DDIEKQEQEEKIKSKKINRRNETSVDEEDENGTHNDE------VNEDEEDDNISSFH 542

  Fly   575 ELIRPLLEKHG-------VIEMPTRPKLSKQERVLKGLYISYYMTASPHVHKL--TP-----SLC 625
            ..:..|::.:|       :..:|...:.|....||       .:|.|.::.:|  ||     .:.
Yeast   543 SAVENLVQGNGNVSESDIINNLPPEKEASSATIVL-------CLTRSSYMLELVNTPLTENILIA 600

  Fly   626 QLYKDFICRYLPCAEVDIFEWSIKCGTTFSIFYEAYSREVFEVVVVQFCKNNNVRLCEASANCIL 690
            .|....|...:.....:|.|..:|                            |:.||     |:|
Yeast   601 SLMDTLITPAVRNTAPNIRELGVK----------------------------NLGLC-----CLL 632

  Fly   691 ELLDRYGVDYFNDLNQTGGSLSKTKRRQLY-TMQELYD--DDDGSQSQNNEQNSDILVVLGHYLE 752
            ::  :..:|   ::...|..:||......| .:|.:.|  ...|:...:.|...|.:.:...:.:
Yeast   633 DV--KLAID---NMYILGMCVSKGNASLKYIALQVIVDIFSVHGNTVVDGEGKVDSISLHKIFYK 692

  Fly   753 RVQHRGV---GMAIVRGLCRLVLRG-HVDDRTDVLELLLKRYFNP-NTEPIINQVLGLFF----- 807
            .:::.|:   .:....|||:|.|.. ..||  |:.|.|:..||:| |:.   |:.|...|
Yeast   693 VLKNNGLPECQVIAAEGLCKLFLADVFTDD--DLFETLVLSYFSPINSS---NEALVQAFAFCIP 752

  Fly   808 ----------EELRRLNKHSLLQPCFLPTVWTCNYDSPLHGVQPEHLTK---------FFLE--- 850
                      :.:.|.....||:.|.|   |.....|.:..|..|.:.|         |:.:
Yeast   753 VYCFSHPAHQQRMSRTAADILLRLCVL---WDDLQSSVIPEVDREAMLKPNIIFQQLLFWTDPRN 814

  Fly   851 MTVQEMSTPQTNIHNKIAISFLQ-YIQNYFTERKDMCRLLAKELTNLSINVLNGPE---VKAELL 911
            :..|..||.:..:.....|..|: |.|   .|:|::.:::   :||::...|:..:   ...|||
Yeast   815 LVNQTGSTKKDTVQLTFLIDVLKIYAQ---IEKKEIKKMI---ITNINAIFLSSEQDYSTLKELL 873

  Fly   912 ALAENLIQSE-LDPRMIKCIQNFKLVVNGSFNPPPRRNPDEGESDEEYETATVTTAESETAVPAQ 975
            ..::::.::: ||......:...:..:|........|:  |.::.:|..||.    :..:::...
Yeast   874 EYSDDIAENDNLDNVSKNALDKLRNNLNSLIEEINERS--ETQTKDENNTAN----DQYSSILGN 932

  Fly   976 SQPPVTEESPNDVTQSAA-ITAVDATETPKAAAPPAPVPEPIVTTFGKDNIVGIRHLRRSMAISH 1039
            |    ..:|.||..:.|| ||..:.||..|...                ||         .|:.:
Yeast   933 S----FNKSSNDTIEHAADITDGNNTELTKTTV----------------NI---------SAVDN 968

  Fly  1040 SDAESLLGPQSPNPEESTESEA--VETSKQNLRQPQMRRRLEMAIARSSKTPEKQP---STEEES 1099
            :..:|       |..:.|.|||  ::||| ||....::....:|...|...|:::.   |.:||.
Yeast   969 TTEQS-------NSRKRTRSEAEQIDTSK-NLENMSIQDTSTVAKNVSFVLPDEKSDAMSIDEED 1025

  Fly  1100 SDEE 1103
            .|.|
Yeast  1026 KDSE 1029

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cap-G	NP_995827.2	YCG1	49..>526	CDD:227543	113/530 (21%)
		HEAT repeat	95..124	CDD:293787	4/44 (9%)
		HEAT repeat	134..163	CDD:293787	7/30 (23%)
		HEAT repeat	176..203	CDD:293787	7/26 (27%)
		HEAT repeat	214..240	CDD:293787	8/45 (18%)
		HEAT repeat	243..270	CDD:293787	12/33 (36%)
		Cnd3	603..902	CDD:289489	65/341 (19%)
YCG1	NP_010612.2	YCG1	5..1033	CDD:227543	240/1174 (20%)
		HEAT repeat	118..146	CDD:293787	7/27 (26%)
		HEAT repeat	158..196	CDD:293787	10/46 (22%)
		HEAT repeat	205..232	CDD:293787	5/26 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346707
Domainoid	1	1.000	82	1.000	Domainoid score	I1972
eggNOG	1	0.900	-	-		E1_COG5218
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52012
OrthoFinder	1	1.000	-	-		FOG0005734
OrthoInspector	1	1.000	-	-		oto99013
orthoMCL	1	0.900	-	-		OOG6_103650
Panther	1	1.100	-	-	LDO	PTHR14418
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R217
SonicParanoid	1	1.000	-	-		X4725
TreeFam	1	0.960	-	-
	13	12.740