DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cap-G and Ncapg

DIOPT Version :9

Sequence 1:	NP_995827.2	Gene:	Cap-G / 36440	FlyBaseID:	FBgn0259876	Length:	1351	Species:	Drosophila melanogaster
Sequence 2:	NP_062311.1	Gene:	Ncapg / 54392	MGIID:	1930197	Length:	1004	Species:	Mus musculus

Alignment Length:	1133	Identity:	271/1133 - (23%)
Similarity:	488/1133 - (43%)	Gaps:	241/1133 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 MYAIMRQAELKESL------HKRYSK---EMQQLYAKMGHE-SFRKAFINVLKAVLGAEEGNENA 109
            |.|..::..:||:.      |:..:|   .:.:.|..|..: :|::.||:.||..:...:.....
Mouse     1 MAAQKKRLSVKEAFQLAQQPHQNQAKLVVALSRTYGAMDDKTAFQEEFIHYLKYAMVVYKREPAV 65

  Fly   110 NMALNFCATFVTS---SDSDGTEP-----MLAETFHWLLTTYSSNPH-IRYRICYFVNLILKELG 165
            ...::|.|.||||   ||.:..|.     :|...|.:||.::.:|.. :|:|:|...|.:|..:.
Mouse    66 ERVMDFTAKFVTSFHQSDEEEEEEENDGGILNYLFTFLLQSHEANSSAVRFRVCQLTNKLLGNMP 130

  Fly   166 PNAALDDHQCDDILEAMLDRVKDVSASVRKQAVLAMQRLQNPDNPSDVVVGAYMYHLTSDPSPNV 230
            .||.:||...|.|.||||.|:||...:||.|||||:.|||:|.:....||.||:..:.:|.:|.|
Mouse   131 ENAQIDDDLFDKINEAMLIRLKDKIPNVRIQAVLALSRLQDPKDDDCPVVDAYVNVIENDSNPEV 195

  Fly   231 RQCIITCMGRNYITIPHILERLWDVDEKVRRHTY------VNMCNYPVRSYKVAQRLTLLEQGLN 289
            |:.:::|:..:..|:..|:.|..|:.:.||:..|      |:|     |:..:|||:.||:||||
Mouse   196 RRAVLSCIAPSAKTLSKIVGRTKDIKDTVRKLAYQVLAEKVHM-----RAMSIAQRVLLLQQGLN 255

  Fly   290 DTSATVRKTVINFMLKTWIESYQQNYVALIAALKLDSNEEELLRFRRVAKQMLRVIFQQTDIKQL 354
            |.|..|::.|...:|:.|:...:.|.:..:..|.::::.:       ||..:|..:|..|.:.:|
Mouse   256 DRSDAVKQAVQKHLLQGWLRFTEGNILEFLHRLDVENSSD-------VAVSVLHSLFSMTPLSEL 313

  Fly   355 IDQLPLSEDCELHRCIPHDSVTVELLLYWQCLSEYLETEAPE----IESLLPELSVFCTYMDKFC 415
            :.   :.::.:..:.||.:::|.|:.|||..|.|||.::..|    :|.:|||.:|:..|:..:.
Mouse   314 VG---ICKNDDGRKLIPVETLTPEIALYWCTLCEYLRSKGDEGEEFLEQILPEPAVYAEYLLSYI 375

  Fly   416 Q-------FQKPDMDKFAQV---EF--QNMLLSLVEILETYDLGDEIGRGNMRLLITNLLKDCLL 468
            |       .||.|......:   ||  |.::|    |:::.|..:|.||  .|||.  :|::.|:
Mouse   376 QGFPVVNEEQKGDFTFIGDLMKREFIGQQLIL----IMKSLDTSEEGGR--KRLLA--ILQETLI 432

  Fly   469 ----DHKIVRVLVRCMEQLITDTNDRIQYFIEIIYELCELNTKQNDLIHDRSLINKLLDDLDTPL 529
                ...:|.::|..:..:|.|.|:|||...|||.|:            ...::|.::|..||..
Mouse   433 LPTTPISLVSLIVERLLHIIRDDNERIQIVTEIISEI------------RAPIVNVVVDPSDTRK 485

  Fly   530 K-MKISSLKVKILELEELEGNYVRQREYIRAQSVND----------------EKIAVTEEYTE-- 575
            | :|::.:|||::|.:|...|.:..:::.:|..:.:                |::.:.|.:||
Mouse   486 KELKMAEIKVKLIEAKEALENCIAVQDFDQASKLKEEIKILEDAKINLLKETEQLEIKEVHTEKN 550

  Fly   576 ----------LIRPLLEKHGVIEMPTRPKLSKQERVLKGLYISYYMTASPHVHKLTPSLCQLYKD 630
                      |...||:     :|.|...::   ..:.|:..|..:.....||.:..:|..|
Mouse   551 DAETLQKCLVLCYELLK-----QMSTSTGIT---ATMNGIIESLILPGIISVHPIVRNLAVL--- 604

  Fly   631 FICRYLPCAEVDIFEWSIKCGTTFSIFYEAYSREVFEVVVVQFCKNNNVRLCEASANCILELLDR 695
              |  |.|..:...:::.|   .|.:|             :|..:.::|.:..::...|::.|..
Mouse   605 --C--LGCCGLQNRDFASK---HFMLF-------------LQVLQIDDVTIKISALKAIIDQLMM 649

  Fly   696 YGVDYFNDLNQTGGSLSKTKRRQLYTMQ-ELYDDDDGSQSQNNEQNSDILVVLGHYLE-RVQHRG 758
            :|::.|        ...|.|..|....: ..:|..:.:.:...:....:|.:|..:|: .|....
Mouse   650 FGIEPF--------KTQKVKGVQCEGEEINCHDKQEENDAGETDPAKSVLKLLSDFLDSEVSELR 706

  Fly   759 VGMAIVRGLCRLVLRG-HVDDRTDVLELLLKRYFNPNTEPII--NQVLGLFFEELRRLNKHSLLQ 820
            .|.|  .||.:|:..| .|..|  :|..|:..::||.||..:  ...||:||......|:.:  |
Mouse   707 TGAA--EGLAKLMFSGLLVSSR--ILSRLILLWYNPVTEEDVRLRHCLGVFFPMFAYANRTN--Q 765

  Fly   821 PC----FLPTVWT---CNYDSPLHGVQPEHLTKFFLEMTVQEMSTPQT---------NIHNKIAI 869
            .|    |:|||.|   ....|||..|...::.:..:::|......|:.         .:|:.:||
Mouse   766 ECFEEAFIPTVQTLANAPVSSPLAEVDVTNVVELLVDLTRPSRLNPKAKNSQDYQALTVHDNLAI 830

  Fly   870 SFLQYIQNYFTERKDMCRLLAKELTNLSINVLNGPEVKAELLALAENLIQSELDPRMIKCIQNFK 934
            .....|.......::.....|..|..||.||..      :||.|.:.:::...|...::.::..|
Mouse   831 KICNEILTSPCSPENRVYTKALSLVELSSNVTK------DLLLLLDEILEHVTDRTCLRALEKIK 889

  Fly   935 LVVNGSFNPPPRRNPDEGESDEEYETATVTTAESETAVPAQSQ----PPVTEESPNDVTQSAAIT 995
            ..:              |:..:|.:...||...:.|....|::    .||.:..
Mouse   890 SQL--------------GKGGKESDPGVVTQDVNTTTAVLQNENEYMTPVRDGK----------- 929

  Fly   996 AVDATETPKAAAPPAPVPEPIVTTFGKDNIVGIRHLRRSMAISHSD-AESLLGPQSPNPEESTES 1059
               .|:|.|             :|.||..    |..|::...|.:: ...:.||.|       ||
Mouse   930 ---GTQTSK-------------STQGKSK----RGCRKAPVSSKTNRRRQIAGPDS-------ES 967

  Fly  1060 EAVETSKQNLRQPQMRRRLEMAIARSSK 1087
            :....|:..:|.|   ||.:.|..:.||
Mouse   968 DHEPPSEMKMRLP---RRAKTAALQKSK 992

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cap-G	NP_995827.2	YCG1	49..>526	CDD:227543	148/515 (29%)
		HEAT repeat	95..124	CDD:293787	8/31 (26%)
		HEAT repeat	134..163	CDD:293787	9/29 (31%)
		HEAT repeat	176..203	CDD:293787	16/26 (62%)
		HEAT repeat	214..240	CDD:293787	9/25 (36%)
		HEAT repeat	243..270	CDD:293787	9/32 (28%)
		Cnd3	603..902	CDD:289489	68/319 (21%)
Ncapg	NP_062311.1	HEAT_2	103..204	CDD:290374	41/100 (41%)
		HEAT repeat	212..234	CDD:293787	6/21 (29%)
		Cnd3	557..859	CDD:289489	70/346 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850574
Domainoid	1	1.000	200	1.000	Domainoid score	I3038
eggNOG	1	0.900	-	-		E1_COG5218
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44071
Inparanoid	1	1.050	224	1.000	Inparanoid score	I3503
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52012
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005734
OrthoInspector	1	1.000	-	-		oto92059
orthoMCL	1	0.900	-	-		OOG6_103650
Panther	1	1.100	-	-	LDO	PTHR14418
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R217
SonicParanoid	1	1.000	-	-		X4725
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790