DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cap-G and cnd3

DIOPT Version :9

Sequence 1:	NP_995827.2	Gene:	Cap-G / 36440	FlyBaseID:	FBgn0259876	Length:	1351	Species:	Drosophila melanogaster
Sequence 2:	NP_588207.1	Gene:	cnd3 / 2539121	PomBaseID:	SPCC188.03	Length:	875	Species:	Schizosaccharomyces pombe

Alignment Length:	1006	Identity:	217/1006 - (21%)
Similarity:	372/1006 - (36%)	Gaps:	249/1006 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 YSKEMQQLYAKMGHESFRKAFINVLKAVLGAEEGNENANMALNFCATFVT-----SSDSDGTEPM 131
            :.|...:|:.....|.|....:..|..:|..::||.||:..|.|..|||.     ..:.|..:|:
pombe    17 HRKLCNKLFTLRTQEGFETDILRALNIILTVKKGNSNADRVLRFLVTFVNYLQQKDPEIDIVQPI 81

  Fly   132 LAETFHWLLTTYSSNPHIRYRICYFVNLI---LKELGPNAALDDHQCDDILEAMLDRVKDVSASV 193
            |.   |.|....:.:..:|||.|..:..:   :||      :||...:.:.|.:|.||.|..:.|
pombe    82 LK---HILRGLDAKDKTVRYRCCQIIARVVNCVKE------IDDDLYNTLKEKLLSRVLDRESIV 137

  Fly   194 RKQAVLAMQRLQNP--DNPSDVVVGAYMYHLTSDPSPNVRQCIITCMGRNYITIPHILERLWDVD 256
            |.:||:|:.|||..  |..:| |....::.|.:|||..||:.::..:..:..|:|.||||..|||
pombe   138 RLEAVVALSRLQEDTGDEEND-VRNILLFLLQNDPSSEVRRSVLLNIEVSNSTLPFILERARDVD 201

  Fly   257 EKVRRHTYVNMCNYP----VRSYKVAQRLTLLEQGLNDTSATVRKTVINFMLKTWIESYQQNYVA 317
            ...|:..|..:  .|    .|...:.:|:.:|:.||||...:|.|...:.:...|||:...|.:.
pombe   202 AANRKCVYARV--LPKIGDFRYLSIKKRVRILKWGLNDRDESVEKAAADMLAYQWIENADNNLLE 264

  Fly   318 LIAALKLDSNEEELLRFRRVAKQMLRVIFQQTDIK-QLIDQLPLSEDCELHRCIPHDSVTVELLL 381
            |:..|.:.:|.:       ||...::..|   |:: ..:.||...|...|       .:|.|..|
pombe   265 LLERLDVSNNSD-------VAVLAIKKFF---DVRVDSLSQLEFPEQFWL-------ELTAESSL 312

  Fly   382 YWQCLSEY-LETEAPEIESLLPELSVFCTYMDKFCQF----QKPDMDKFAQVEFQNMLLSLVEIL 441
            ..:..:|. :|....::...:||:.....|:::  |:    .|...|:...:..|.:.:.|
pombe   313 LARTFNEICIEKNYTDLLDKMPEVVQLTYYIER--QYVSLRDKSSYDESCFIIEQLLYIGL---- 371

  Fly   442 ETYDLGDEIGRGNMRLLITNLLKDCLLDHKIVRVLVRCMEQLITDTNDRIQYFIEIIYELCELNT 506
             :.|:.|||||..:...:||.|....|...::.:.:..:.:|.:..||.....:|||.|:.|...
pombe   372 -SQDMVDEIGRRKLLKSLTNSLSTMALPDSLISLHIELLRKLCSSENDFCSLLVEIITEVFEQGH 435

  Fly   507 KQNDLIHDRSL----INK---LLDDLDTPLKMKISSLKVKIL---ELEELEG-----NYVRQREY 556
            .||......:.    :||   ..:::....|....||....|   |.::::|     |.:|...|
pombe   436 SQNQTEEQGNSNAPELNKNDYEGEEITVSQKSPSPSLPPNELNEPEPDDMDGYKEAFNELRCLSY 500

  Fly   557 IRAQSVN-----DEKIAVTEEYTELIRPLLEKHGVIEMPTRPKLSKQERVLKGLYISYYMTASPH 616
            ::....|     :|.:.:.:....||.|.:..|   ::|.|.         |||
pombe   501 VQCLFENITSSLNENLYMVDMLKTLIIPAVRSH---DLPIRE---------KGL----------- 542

  Fly   617 VHKLTPSLCQLYKDF----ICRYLPCAEVDIFEWSIKCGTTFSIFYEAYSREVFEVVVVQFCKNN 677
              :....:|.|..|.    :..||.|.|                                  |.:
pombe   543 --ECLSLVCLLNADLAFENVPLYLHCYE----------------------------------KGS 571

  Fly   678 NVRLCEASANCILELLDRYGVDYFNDLNQTGGS-----LSKTKRRQLYTMQELYDDDDGSQSQNN 737
            .|..|.| ...:.::|.::|...|.:......|     |.:.:..:|.|:             ..
pombe   572 VVLKCTA-IRTLTDMLIQHGKAKFTEYEDAISSILFEALGEFENAELQTL-------------GA 622

  Fly   738 EQNSDILVVLGHYLERVQHRGVGMAIVRGLCRLVLRGHVDDRTDVLELLLKRYFNPNT--EPIIN 800
            |..:.:||:| ||.:.:                           .|:.|:.:||.|||  ...:.
pombe   623 EAIAKLLVIL-HYRDEL---------------------------FLKPLIIQYFEPNTVDNHALR 659

  Fly   801 QVLGLFFEELRRLNKHSLLQPCF----------LPTVWTCN---------YDSPLHGVQPE--HL 844
            ||||.||             |.:          :.|:: |:         .|.....||..  |:
pombe   660 QVLGYFF-------------PVYAFGAHENQWRIATIF-CDALLSLLEIYRDLDEDDVQLSIGHI 710

  Fly   845 TKFFLEMT----VQEMSTPQT---------NIHNKIAISFLQYIQNYF--TERKDMCRLLAKELT 894
            .:..|:.|    :.|..| ||         |:|..:|....:.:.|..  .|||.|..||.|...
pombe   711 AQQMLDWTDNEKLYERKT-QTGDDYIALNHNVHLHLANMIFESLPNASEGKERKFMISLLGKLKI 774

  Fly   895 NLSINVLNGPEVKAELLALAENLIQSE---LDPRMIKCIQNFKLVVNGSFNPPPRRNPDEGESDE 956
            ...:...:....|.:|     ...:|.   :|...:..:..|:.::  ..|...|...:|.|.:.
pombe   775 PTDLPSSDYQRTKRKL-----ETYESHGFTMDSTSLSILAKFERML--LQNEEARSKFEETEEER 832

  Fly   957 EYETATVTTAESETAVPAQSQPPVTEESPND 987
            ..|.|.........|:..:..|...|.:..|
pombe   833 LMENAEENEHAGAEAISGEIIPDTVEANMED 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cap-G	NP_995827.2	YCG1	49..>526	CDD:227543	121/480 (25%)
		HEAT repeat	95..124	CDD:293787	11/33 (33%)
		HEAT repeat	134..163	CDD:293787	6/31 (19%)
		HEAT repeat	176..203	CDD:293787	10/26 (38%)
		HEAT repeat	214..240	CDD:293787	7/25 (28%)
		HEAT repeat	243..270	CDD:293787	11/26 (42%)
		Cnd3	603..902	CDD:289489	64/345 (19%)
cnd3	NP_588207.1	YCG1	1..875	CDD:227543	217/1006 (22%)
		HEAT repeat	81..109	CDD:293787	7/30 (23%)
		HEAT repeat	121..151	CDD:293787	13/29 (45%)
		HEAT repeat	158..183	CDD:293787	8/25 (32%)
		HEAT repeat	186..210	CDD:293787	10/23 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	126	1.000	Domainoid score	I1388
eggNOG	1	0.900	-	-		E1_COG5218
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52012
OrthoFinder	1	1.000	-	-		FOG0005734
OrthoInspector	1	1.000	-	-		oto100501
orthoMCL	1	0.900	-	-		OOG6_103650
Panther	1	1.100	-	-	LDO	PTHR14418
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R217
SonicParanoid	1	1.000	-	-		X4725
TreeFam	1	0.960	-	-
	12	11.810