DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13326 and Odad2

DIOPT Version :9

Sequence 1:	NP_610838.1	Gene:	CG13326 / 36439	FlyBaseID:	FBgn0033794	Length:	867	Species:	Drosophila melanogaster
Sequence 2:	NP_001344421.1	Gene:	Odad2 / 74934	MGIID:	1922184	Length:	1037	Species:	Mus musculus

Alignment Length:	942	Identity:	179/942 - (19%)
Similarity:	313/942 - (33%)	Gaps:	305/942 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 DTALLLLSSKEECVLLTIFSHITDFARRQD-------VNVLELKAHRLLELLLE----------- 83
            :|..|.::...|.:|..|...:..|:.:..       |..||.|.:      ||
Mouse    17 ETGTLEITPLNESILNEITKFVESFSYKYPQEAKFVFVEPLEWKTY------LEPSAFELGYVVS 75

  Fly    84 ----------KD----LFIASENTMIRRFALYLLTALLDNTDMSTYEPEQA------DQILELAC 128
                      ||    ||::.....:|.|.  .|:.||.....|..:..||      |.::::..
Mouse    76 ATTAESEETGKDGQPLLFLSVPYIKVRSFG--QLSQLLSIATDSKLQEAQACIEANRDPVVKILG 138

  Fly   129 RFYMKEVDDFCIEYLTYILNVCLKDPQ------MAHGIVEATEFLEKFKLVFISSE---NPDTVF 184
            ..|.:..:|  ...|| :|:..:||.:      :|..:.:....|....|.:||.|   ||.|..
Mouse   139 PDYNEMKED--PTRLT-LLDTIIKDKETYMKRKVAILLKQLDLHLLNHSLKYISLEISLNPGTFK 200

  Fly   185 NSIEALHRM--LLVQSADQMLDFTTQPDF-------PVDRI---ICEV----------------- 220
            ..||.|.|.  ...|:..:.:::|:..:|       |..:|   ||.|
Mouse   201 KDIELLKRFSGKGEQTVLESIEYTSDYEFSNGCRAPPWRQIQGEICYVLVKPHDMETLCLTCSTE 265

  Fly   221 --------TNEFQEI---RKAAL-KTLKTLLADTGDDSVFE---ALHRCYFVLEQLV--KVFCES 268
                    |.|..||   ||..: |.|.|.|.|  ...||.   :.|...|..||..  ::|
Mouse   266 GVFLNGGKTEEEGEINYERKGEIYKDLVTCLKD--KSPVFSENMSKHEIRFTEEQQKDNQIF--- 325

  Fly   269 PQGPEAADVIEVLATALRSEKMTKLFF---------EQNLFDQVVEQVRNHMDLM---------P 315
             :.|:..|....:|.:.:| |:.|:.|         |.:|..:|....::|...:         .
Mouse   326 -EKPKTEDGHSSVAGSEKS-KIEKISFGKSPMTKRLEPSLNWRVTVDYKDHKSSIKDSQEEKQGK 388

  Fly   316 LEMRCTIISIFAETAQ--------------------YEQFLPRMHKAEI-ADM------------ 347
            || :.:.:|:....||                    .|...|..|:.|. ||:
Mouse   389 LE-KSSSVSVAPSRAQSHRKGGEKVEETVSESSSESEEDEEPPDHRQEANADLPSEYWQIQKLVK 452

  Fly   348 FL-----------------------TCLMQNKPAPAAYV----------------IQGLHRMSHH 373
            :|                       ||.:..:......|                ::.|..:||:
Mouse   453 YLKGGNQTATVIALCSMRDFNLAQETCQLAIRDVGGLEVLINLLDTDEVKCKIGSLKILKEISHN 517

  Fly   374 PEALRRIVAAYQEGAIRKLVAILMSPDVAIKAREQAGEFLSRLLVAAFRETAAQLQEQDIAVVLT 438
            |:..|.||   ..|.:..:|.||.||..::|.  .:.|.::.  ||.|:.....:::......|.
Mouse   518 PQIRRNIV---DLGGLPIMVNILDSPHKSLKC--LSAETIAN--VAKFKRARRAVRQHGGITKLV 575

  Fly   439 AVIAQG-------QPTL----SIDL----ILLLLTIIESLAQKEEYRTILGEYSSLTEQLAQLLM 488
            |::..|       ||:|    .:::    .|.|.:..:|.:.||..|...|     ...||:||.
Mouse   576 ALLDCGQNSTEPTQPSLYETRDVEVARCGALALWSCSKSHSNKEAIRKAGG-----IPLLARLLK 635

  Fly   489 RSFAHSIL--VNNIFRCLCTLIDEAPVRETLLANYIVSSMKRALKSLSNLVKTSVTNFILQTTRF 551
            .|..:.::  |..:..|    ..|...|..:.|..|:.::.:.|.|.:..::......|.|....
Mouse   636 TSHENMLIPVVGTLQEC----ASEENYRAAIKAERIIENLVKNLNSENEQLQEHCAMAIYQCAED 696

  Fly   552 NEFIDAYIDRGIMEVLLDF-----QKHAFCISTWGPAIESILSKCPTMKFAIRNCLTFTDITAGK 611
            .|..|.....|.::.|...     .|....      |:...:.||...|   .|.:
Mouse   697 EETRDLVRLHGGLKPLASLLNNTDNKERLA------AVTGAIWKCSISK---ENVI--------- 743

  Fly   612 DFYVSRRKFEDFRKF-----------QDILRNDCSPL--------DAVLVMNFDRPKPNQNDVIA 657
                   ||.:::..           :::|.|....|        :.|||......:|..|.::.
Mouse   744 -------KFREYKAIETLVGLLTDQPEEVLVNVVGALGECCQEYENRVLVRKCGGIQPLVNLLVG 801

  Fly   658 VPLRCLSTITDLPGDQGWGYCKRPGDNNLPQYLEALNQTLAMHGLVENPE-RVRRTIDF------ 715
            :....|..:|     :..|.|....::  ...::.|:....:..|::||. .|:.:..:
Mouse   802 INQALLVNVT-----KAVGACAVEPES--MAIIDRLDGVRLLWSLLKNPHPDVKASAAWALCPCI 859

  Fly   716 ENVAKRSKLIAQ-------AVNAVMSENLKIL 740
            ||.....:::..       .||.:.|:|.::|
Mouse   860 ENAKDAGEMVRSFVGGLELVVNLLKSDNKEVL 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13326	NP_610838.1	EDR1	<759..799	CDD:291079
Odad2	NP_001344421.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	316..353		10/41 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	376..439		9/63 (14%)
		armadillo repeat	447..472	CDD:293788	1/24 (4%)
		ARM 1. /evidence=ECO:0000255	477..516		4/38 (11%)
		armadillo repeat	482..514	CDD:293788	2/31 (6%)
		ARM 2. /evidence=ECO:0000255	518..557		13/45 (29%)
		armadillo repeat	521..557	CDD:293788	12/42 (29%)
		armadillo repeat	564..610	CDD:293788	8/45 (18%)
		ARM 3. /evidence=ECO:0000255	615..654		11/47 (23%)
		PLN03200	<618..>855	CDD:215629	48/277 (17%)
		armadillo repeat	620..652	CDD:293788	8/36 (22%)
		ARM 4. /evidence=ECO:0000255	656..695		7/38 (18%)
		armadillo repeat	658..695	CDD:293788	7/36 (19%)
		armadillo repeat	700..733	CDD:293788	5/38 (13%)
		ARM 5. /evidence=ECO:0000255	739..778		7/57 (12%)
		armadillo repeat	742..778	CDD:293788	5/51 (10%)
		SRP1	<750..1035	CDD:227396	24/149 (16%)
		ARM 6. /evidence=ECO:0000255	821..860		5/40 (13%)
		armadillo repeat	823..860	CDD:293788	5/38 (13%)
		ARM 7. /evidence=ECO:0000255	864..903		5/28 (18%)
		armadillo repeat	876..901	CDD:293788	5/16 (31%)
		ARM 8. /evidence=ECO:0000255	905..944
		armadillo repeat	908..985	CDD:293788
		HEAT repeat	919..947	CDD:293787
		ARM 9. /evidence=ECO:0000255	946..985
		ARM 10. /evidence=ECO:0000255	987..1026
		armadillo repeat	991..1024	CDD:293788
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0167
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2332
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840