DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13326 and pkp4

DIOPT Version :9

Sequence 1:	NP_610838.1	Gene:	CG13326 / 36439	FlyBaseID:	FBgn0033794	Length:	867	Species:	Drosophila melanogaster
Sequence 2:	XP_690071.3	Gene:	pkp4 / 561566	ZFINID:	ZDB-GENE-120411-14	Length:	1136	Species:	Danio rerio

Alignment Length:	438	Identity:	87/438 - (19%)
Similarity:	147/438 - (33%)	Gaps:	145/438 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 IRRFALYLLTALLDNTDMSTYE-----PEQADQILELACRFYMKEVDDFCIEYLTYILNVCLKDP 154
            |.|.||..||    ||.:..:.     |::.||.|:|.....::.... |:..|:.......:..
Zfish   599 ITRDALGPLT----NTVIIPHSGWGAAPQREDQKLKLHSSLVLRNTTG-CLRNLSSAGEEARRQM 658

  Fly   155 QMAHGIVEATEFLEKFKLVFISSENPDTVFNSIEALHRMLLVQSADQMLDFTTQPDFPVDRIICE 219
            :...|::::..::.| ..|..|..:...|.|.:..|..          |.:..:.:.|..|::
Zfish   659 RCCEGLIDSLLYIIK-TCVNTSDYDSKIVENCVCTLRN----------LSYRLELEMPPSRLM-- 710

  Fly   220 VTNEFQEIRKAALKTLKTLLADTGDDSVFEALHRCYFVLEQLVK---------------VFCESP 269
                       ..:.|.|||..  |.|..:|.:.|:.:.::..|               .|..||
Zfish   711 -----------GTQDLDTLLGP--DTSSKQADYSCWGLRKKKKKRSWQDQQWDGVGPIPGFSGSP 762

  Fly   270 QGPE--------------------------AADVIEVLA-----------TALRSEK----MTKL 293
            :|.|                          ||..::.|:           .|:|.||    :.:|
Zfish   763 KGAEMLWHPSVVKPYLTLLAESSNPATLEGAAGSLQNLSAGTWRFASYIRAAVRKEKGLPILVEL 827

  Fly   294 FFEQNLFDQVVEQVRNHMDLMPLEMRCTIISIFAETAQYEQFLPRMHKAEIADMFLTCLMQNKPA 358
            ....|  |:||..|...:..|.|:.|...:               :.|..:.|: :|.|..|.|:
Zfish   828 LRMDN--DRVVCSVATALRNMALDARNKEL---------------IGKYAMRDL-VTRLPGNGPS 874

  Fly   359 -----PAAYVIQGLHRM-SHHPEALRRIVAAYQEGAIRKLVAILMSPDVAIKAREQAGEFLSRLL 417
                 ..|.|...||.: |.:.|..|   |..|.|.|.|||.|         :|.:...:..:::
Zfish   875 LLSDETVAAVCCALHEVTSRNMENAR---ALAQTGGIDKLVTI---------SRGRGERYSMKVV 927

  Fly   418 VAAFRETAAQLQEQDIAV-----------VLTAVIA------QGQPTL 448
            .||.:......|.:|:..           .:|.|..      :.||||
Zfish   928 KAAAQVLNTLWQYRDLRTFYKKDGWNQNHFITPVSTLERDRYRSQPTL 975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13326	NP_610838.1	EDR1	<759..799	CDD:291079
pkp4	XP_690071.3	DUF966	<105..>252	CDD:283735
		ARM	469..591	CDD:237987
		armadillo repeat	477..502	CDD:293788
		HEAT_2	506..580	CDD:290374
		armadillo repeat	510..546	CDD:293788
		armadillo repeat	554..589	CDD:293788
		armadillo repeat	595..647	CDD:293788	14/52 (27%)
		ARM	636..>699	CDD:237987	10/74 (14%)
		armadillo repeat	765..802	CDD:293788	4/36 (11%)
		ARM	766..893	CDD:237987	27/144 (19%)
		armadillo repeat	812..846	CDD:293788	10/35 (29%)
		armadillo repeat	853..893	CDD:293788	10/55 (18%)
		armadillo repeat	899..934	CDD:293788	12/46 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2332
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030