DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13326 and ARVCF

DIOPT Version :9

Sequence 1:	NP_610838.1	Gene:	CG13326 / 36439	FlyBaseID:	FBgn0033794	Length:	867	Species:	Drosophila melanogaster
Sequence 2:	XP_006724306.1	Gene:	ARVCF / 421	HGNCID:	728	Length:	1004	Species:	Homo sapiens

Alignment Length:	321	Identity:	65/321 - (20%)
Similarity:	110/321 - (34%)	Gaps:	104/321 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 EFQEIRKAALKTLKTLLA--DTGDDSVFEALHRCYFVLEQL----------VKVFCESPQGPEAA 275
            |.:.:..|.|..|::.:.  ||.:.||    ..|..::..|          ...:.|:..||
Human   542 ECEGLVDALLHALQSAVGRKDTDNKSV----ENCVCIMRNLSYHVHKEVPGADRYQEAEPGP--- 599

  Fly   276 DVIEVLATALRSE-------------KMTKLFFEQNLFDQVVEQVRNHMDLMPLEMRCTIISIFA 327
                 |.:|:.|:             |..:.:|.|...|.  |..|| .|.:.|..|       .
Human   600 -----LGSAVGSQRRRRDDASCFGGKKAKEEWFHQGKKDG--EMDRN-FDTLDLPKR-------T 649

  Fly   328 ETAQYEQFLPRMHKAEIADMFLTCLMQ----NKPAPAAYVIQGLHRMSHHPEALRRIVAAYQEGA 388
            |.|:..:.|   ::.|:..::|:.|.:    |....||..:|.|       .|...:.|.|....
Human   650 EAAKGFELL---YQPEVVRLYLSLLTESRNFNTLEAAAGALQNL-------SAGNWMWATYIRAT 704

  Fly   389 IRK------LVAILMS-PDVAIKA--------------REQAGEFLSRLLVAAFRETAAQ----- 427
            :||      ||.:|.| .|..::|              ::..|.:....||...|...|.
Human   705 VRKERGLPVLVELLQSETDKVVRAVAIALRNLSLDRRNKDLIGSYAMAELVRNVRNAQAPPRPGA 769

  Fly   428 -LQEQDIAVVLTAV---------------IAQGQPTLSIDLILLLLTIIESLAQKEEYRTI 472
             |:|..:..||..:               .|:|.|.| :.|:....::.|:.|.....:|:
Human   770 CLEEDTVVAVLNTIHEIVSDSLDNARSLLQARGVPAL-VALVASSQSVREAKAASHVLQTV 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13326	NP_610838.1	EDR1	<759..799	CDD:291079
ARVCF	XP_006724306.1	ARM	355..473	CDD:237987
		HEAT_2	360..462	CDD:290374
		armadillo repeat	360..385	CDD:293788
		armadillo repeat	393..429	CDD:293788
		armadillo repeat	436..471	CDD:293788
		ARM	437..579	CDD:237987	9/40 (23%)
		armadillo repeat	478..529	CDD:293788
		ARM	656..756	CDD:237987	22/109 (20%)
		armadillo repeat	656..692	CDD:293788	9/45 (20%)
		armadillo repeat	702..736	CDD:293788	8/33 (24%)
		armadillo repeat	743..788	CDD:293788	9/44 (20%)
		armadillo repeat	794..826	CDD:293788	7/32 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2332
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030