DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13326 and JUP

DIOPT Version :9

Sequence 1:	NP_610838.1	Gene:	CG13326 / 36439	FlyBaseID:	FBgn0033794	Length:	867	Species:	Drosophila melanogaster
Sequence 2:	XP_016880077.1	Gene:	JUP / 3728	HGNCID:	6207	Length:	762	Species:	Homo sapiens

Alignment Length:	798	Identity:	152/798 - (19%)
Similarity:	265/798 - (33%)	Gaps:	257/798 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 RVYEAKST---------------YPDRTKSEEKSFTEVSVP-IKKLDTALLLLSSKE-------- 47
            |.|..|.|               |...|.:..|...|...| :...|::|||.:..|
Human    68 RQYTLKKTTTYTQGVPPSQGDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQATNLQR 132

  Fly    48 ----ECVLLTIFSHITDFARRQDVNVLELKAHRLLELLLEKDLFIASENTMIRRFALYLLTALLD 108
                ..:|.:...|:.::  :.|..:.......|.:||.::|..:.::..||        ...|.
Human   133 LAEPSQLLKSAIVHLINY--QDDAELATRALPELTKLLNDEDPVVVTKAAMI--------VNQLS 187

  Fly   109 NTDMSTYEPEQADQILELACRFYMKEVDDFCIEYLTYILNVCLKDPQMAHGIVEATE-FLEKFK- 171
            ..:.|......:.|::....|......|.......|.||          |.:....| .|..||
Human   188 KKEASRRALMGSPQLVAAVVRTMQNTSDLDTARCTTSIL----------HNLSHHREGLLAIFKS 242

  Fly   172 -----LV-FISSENPDTVFNSIEALHRMLLVQSADQMLDFTTQPDFPVDRIICEVTNEFQEIRKA 230
                 || .:||.....:|.:|..||.:||                            :||..|.
Human   243 GGIPALVRMLSSPVESVLFYAITTLHNLLL----------------------------YQEGAKM 279

  Fly   231 ALKTLKTLLADTGDDSVFEALHRCYFVLEQLVKVFCESPQGPE----AADVIEVLATALRSEKMT 291
            |::     |||.               |:::|.:.  :...|:    ..|.:::||   ...:.:
Human   280 AVR-----LADG---------------LQKMVPLL--NKNNPKFLAITTDCLQLLA---YGNQES 319

  Fly   292 KLFFEQNLFDQVVEQV-RNHMDLMPLEMRCTIISIFAETAQYEQFL---PRMHKAEIADMFLTCL 352
            ||....|...|.:.|: ||:                    .||:.|   .|:.|.      |:..
Human   320 KLIILANGGPQALVQIMRNY--------------------SYEKLLWTTSRVLKV------LSVC 358

  Fly   353 MQNKPAPAAYVIQ-------GLHRMSHHPE-------ALRRI--VAAYQEG--AIRKLVAILMSP 399
            ..||||    :::       |.|..|:.|.       .||.:  ||..|||  ::.|::...:|.
Human   359 PSNKPA----IVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSV 419

  Fly   400 DVAIKAREQAGEFLSRLLVAAFRETAAQLQEQDIAVVLTAVIAQG------QPTL---------- 448
            | .:.....|...||.|.....:......|...:..::.|::..|      :|.:
Human   420 D-DVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRH 483

  Fly   449 --------SIDLILLLLTIIESLAQKEEY---RTILG---------------EYSSLTEQLAQLL 487
                    |:.|...:..|::.|.|..::   :..:|               :.:::..:|.|||
Human   484 PEAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLL 548

  Fly   488 MRSFAHSILVNNIFRCLCTLIDEAPVRETLLANYIVSSMKRALKSLSNLVKTSVTNFILQT-TRF 551
            ::  ||.....::     ....:.|..:.:....||.....||..|:......:..|.|.| ..|
Human   549 VK--AHQDAQRHV-----AAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLF 606

  Fly   552 NEFIDAYIDR------GIMEVLLDFQKHAFCISTWG---PAIESILSKCPTMKFAIRNCLTFTDI 607
            .:.:.:.::.      |::..|...::.|..|...|   |.:|.:.|         ||..|.| .
Human   607 VQLLYSSVENIQRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHS---------RNEGTAT-Y 661

  Fly   608 TAGKDFYVSRRKFEDFRK------FQDILRNDCSPLDA---VLVMNFDRPKPNQNDVIA------ 657
            .|...|.:|..|..|:||      ...:.::|.:..:|   ::.:|    :|..:|:.|
Human   662 AAAVLFRISEDKNPDYRKRVSVELTNSLFKHDPAAWEAAQSMIPIN----EPYGDDMDATYRPMY 722

  Fly   658 ---VPLRCLSTITDLPGD 672
               |||..|....|:.||
Human   723 SSDVPLDPLEMHMDMDGD 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13326	NP_610838.1	EDR1	<759..799	CDD:291079
JUP	XP_016880077.1	armadillo repeat	161..186	CDD:293788	6/32 (19%)
		armadillo repeat	203..229	CDD:293788	6/35 (17%)
		armadillo repeat	238..270	CDD:293788	10/31 (32%)
		ARM	238..270	CDD:214547	10/31 (32%)
		armadillo repeat	278..314	CDD:293788	11/60 (18%)
		armadillo repeat	322..355	CDD:293788	10/58 (17%)
		PLN03200	<345..>675	CDD:215629	68/357 (19%)
		ARM	358..398	CDD:214547	10/43 (23%)
		armadillo repeat	362..397	CDD:293788	9/38 (24%)
		armadillo repeat	410..435	CDD:293788	6/25 (24%)
		armadillo repeat	443..481	CDD:293788	4/37 (11%)
		armadillo repeat	487..525	CDD:293788	6/37 (16%)
		armadillo repeat	532..589	CDD:293788	12/63 (19%)
		armadillo repeat	594..628	CDD:293788	5/33 (15%)
		armadillo repeat	635..669	CDD:293788	12/43 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2332
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940