DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13326 and ARMC3

DIOPT Version :9

Sequence 1:	NP_610838.1	Gene:	CG13326 / 36439	FlyBaseID:	FBgn0033794	Length:	867	Species:	Drosophila melanogaster
Sequence 2:	NP_775104.2	Gene:	ARMC3 / 219681	HGNCID:	30964	Length:	872	Species:	Homo sapiens

Alignment Length:	990	Identity:	214/990 - (21%)
Similarity:	369/990 - (37%)	Gaps:	289/990 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 FTEVSVPIKKLDTALLLLSSKEECVLLTIFSHITDFARRQDVN---VLELKAHRLLELLLEKDLF 87
            |..:.:..||..|.:|:|:|.||.:|......|..||.:.:.|   :|||.|...|..||
Human    17 FDPLMIESKKAATVVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPLTKLL----- 76

  Fly    88 IASENTMIRRFALYLLTALLDNTD--------------MSTYEPEQADQILELACRFYMKEVDDF 138
             ..|:.::||.|..:...|..|.|              ::...||:...|.|.|
Human    77 -THEDKIVRRNATMIFGILASNNDVKKLLRELDVMNSVIAQLAPEEEVVIHEFA----------- 129

  Fly   139 CIEYLTYILNVCLKDPQMAHGIVEATEFLEKFK-------LVFISSENPDTVFNSIEALHRMLLV 196
                     ::||     |:...|.|..::.|:       :..:||.:||...||:|.::.  ||
Human   130 ---------SLCL-----ANMSAEYTSKVQIFEHGGLEPLIRLLSSPDPDVKKNSMECIYN--LV 178

  Fly   197 QSADQMLDFTTQPDF----PVDRIICEVTNEFQEIRKAALKTL---------KTLLADT-GDDSV 247
            |      ||..:...    .:..|:..:.:|:..|:..|||||         :|:|.|. |.|.:
Human   179 Q------DFQCRAKLQELNAIPPILDLLKSEYPVIQLLALKTLGVIANDKESRTMLRDNQGLDHL 237

  Fly   248 FEALH----------------RCYFVLEQLVKV-----------FCESPQGPE-AADVIEVLATA 284
            .:.|.                .|...::.:|::           |.|:...|: ..:..:.:..|
Human   238 IKILETKELNDLHIEALAVIANCLEDMDTMVQIQQTGGLKKLLSFAENSTIPDIQKNAAKAITKA 302

  Fly   285 LRSEKMTKLFFEQNLFDQVVEQVRNHMDLMPLEMRCTIISIFAETAQYEQF-----LPRM----- 339
            ....:..|||.||.:...:|..:.:..|...: .....||...|.:..:.|     :|::
Human   303 AYDPENRKLFHEQEVEKCLVALLGSENDGTKI-AASQAISAMCENSGSKDFFNNQGIPQLIQLLK 366

  Fly   340 ----HKAEIADMFLTCLMQNKP--APAAYVIQGLHRMSHHPEALRRIVAAYQEGAIRKLVAILMS 398
                ...|.|.:.|..|....|  |.||....|:       :.|..::::.::|||.....:|.:
Human   367 SDNEEVREAAALALANLTTCNPANANAAAEADGI-------DPLINLLSSKRDGAIANAATVLTN 424

  Fly   399 PDVAIKAREQAGEFLSRLLVAAFRETAAQLQEQDIAVVLTAVIAQGQPTLSIDLILLLLTIIESL 463
                               :|........:|..||   :.|:|:   |..|.:      |:::|.
Human   425 -------------------MAMQEPLRLNIQNHDI---MHAIIS---PLRSAN------TVVQSK 458

  Fly   464 AQ--------KEEYRTILGEYSSLTEQLAQLL------MRSFAH-SILVNNIFRC---------L 504
            |.        ..|.||.|.....| |.|.:||      :|..|. :::|     |         |
Human   459 AALAVTATACDVEARTELRNSGGL-EPLVELLRSKNDEVRKHASWAVMV-----CAGDELTANEL 517

  Fly   505 CTL-----IDEAPVRETLLANYIVSSMKRALKSLSNL-VKTSVTNFILQTTRFNEFIDAYIDRGI 563
            |.|     ::|..|..|....:..::..:.|.  :|| :|.|.|.::..:...|   |.:.|.|.
Human   518 CRLGALDILEEVNVSGTRKNKFSEAAYNKLLN--NNLSLKYSQTGYLSSSNIIN---DGFYDYGR 577

  Fly   564 ME---VLLDFQKHAFCISTWGP----AIESILSK---CPTMKFAIRNCLTFTDITAGKDFYVS-- 616
            :.   .||..::  .|:..  |    |:..|.||   .|......:     :|:..|:....|
Human   578 INPGTKLLPLKE--LCLQE--PSDLRAVLLINSKSYVSPPSSMEDK-----SDVGYGRSISSSSS 633

  Fly   617 -RRKFEDFRK---------FQDILRNDCSPL---DAVLVMNFDRPK--------------PNQND 654
             ||..::..|         |...:.:...|.   :.||..:..:.|              ..:.:
Human   634 LRRSSKEKNKKNSYHFSAGFGSPIEDKSEPASGRNTVLSKSATKEKGWRKSKGKKEEEKVKEEEE 698

  Fly   655 VIAVPLRCLSTITDLPGDQGWGYCKRPGDNNLPQYL-EALNQTLAMHGLVENPERVRRTIDFENV 718
            |:.||    ..:.:...|:.|  |. |.|.:...|: |.....|.:..:.|..|.:
Human   699 VMVVP----KFVGEGSSDKEW--CP-PSDPDFSMYVYEVTKSILPITNIKEQIEDL--------- 747

  Fly   719 AKRSKLIAQAVNAVMSENLKILDLNSTEECCRNTVRCHLQELRHVLHTNFIPLGMVRSGCQFERA 783
               :|.:|:.:...:.:. |:.|.         :...|:.||:..|.:|.||:|.|:.|..:.||
Human   748 ---AKYVAEKMGGKIPKE-KLPDF---------SWELHISELKFQLKSNVIPIGHVKKGIFYHRA 799

  Fly   784 ILFKGLADQIGLPCTLQRSVDGRMLYNELPLPLEPEKDVHCDKKTLKYMPWRMLRPTHVVDLLYN 848
            :|||.|||:||:.|:|.|...|| .:||:.|..:..|.|      :..:|   ....:|:||:::
Human   800 LLFKALADRIGIGCSLVRGEYGR-AWNEVMLQNDSRKGV------IGGLP---APEMYVIDLMFH 854

  Fly   849 VGELYPMQSRQALQY 863
            .|.|..::||:|..|
Human   855 PGGLMKLRSREADLY 869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13326	NP_610838.1	EDR1	<759..799	CDD:291079	20/39 (51%)
ARMC3	NP_775104.2	ARM 1	15..54		12/36 (33%)
		armadillo repeat	21..52	CDD:293788	10/30 (33%)
		HEAT_2	32..108	CDD:290374	24/81 (30%)
		ARM 2	57..96		13/44 (30%)
		armadillo repeat	60..96	CDD:293788	12/41 (29%)
		ARM	63..179	CDD:237987	33/148 (22%)
		ARM 3	98..138		9/64 (14%)
		HEAT repeat	106..137	CDD:293787	8/55 (15%)
		ARM 4	140..179		10/40 (25%)
		armadillo repeat	143..177	CDD:293788	8/35 (23%)
		ARM	145..259	CDD:237987	27/121 (22%)
		HEAT_2	152..258	CDD:290374	26/113 (23%)
		ARM 5	181..220		9/38 (24%)
		armadillo repeat	184..220	CDD:293788	8/35 (23%)
		ARM 6	222..262		7/39 (18%)
		armadillo repeat	225..259	CDD:293788	6/33 (18%)
		ARM 7	264..304		5/39 (13%)
		ARM 8	306..345		9/39 (23%)
		ARM	321..426	CDD:237987	21/131 (16%)
		ARM 9	346..385		6/38 (16%)
		armadillo repeat	358..383	CDD:293788	4/24 (17%)
		ARM 10	388..427		10/64 (16%)
		armadillo repeat	391..436	CDD:293788	10/70 (14%)
		ARM 11	429..468		10/50 (20%)
		ARM	435..529	CDD:237987	26/111 (23%)
		armadillo repeat	435..465	CDD:293788	10/41 (24%)
		ARM 12	470..509		13/44 (30%)
		armadillo repeat	473..503	CDD:293788	10/30 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	610..693		12/87 (14%)
		EDR1	<720..858	CDD:291079	45/169 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0167
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D113174at33208
OrthoFinder	1	1.000	-	-		FOG0009670
OrthoInspector	1	1.000	-	-		oto90086
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46618
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2332
SonicParanoid	1	1.000	-	-		X7410
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	8.000