DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13326 and Jup

DIOPT Version :9

Sequence 1:	NP_610838.1	Gene:	CG13326 / 36439	FlyBaseID:	FBgn0033794	Length:	867	Species:	Drosophila melanogaster
Sequence 2:	NP_034723.1	Gene:	Jup / 16480	MGIID:	96650	Length:	745	Species:	Mus musculus

Alignment Length:	798	Identity:	153/798 - (19%)
Similarity:	266/798 - (33%)	Gaps:	257/798 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 RVYEAKST---------------YPDRTKSEEKSFTEVSVP-IKKLDTALLLLSSKE-------- 47
            |.|..|.|               |...|.:..|...|...| :...|::|||.:..|
Mouse    51 RQYTLKKTTTYTQGVPQNQGDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQTTNLQR 115

  Fly    48 ----ECVLLTIFSHITDFARRQDVNVLELKAHRLLELLLEKDLFIASENTMIRRFALYLLTALLD 108
                ..:|.:...|:.::  :.|..:.......|.:||.::|..:.::..||        ...|.
Mouse   116 LAEPSQLLKSAIVHLINY--QDDAELATRALPELTKLLNDEDPVVVTKAAMI--------VNQLS 170

  Fly   109 NTDMSTYEPEQADQILELACRFYMKEVDDFCIEYLTYILNVCLKDPQMAHGIVEATE-FLEKFK- 171
            ..:.|......:.|::....|......|.......|.||          |.:....| .|..||
Mouse   171 KKEASRRALMGSPQLVAAVVRTMQNTSDLDTARCTTSIL----------HNLSHHREGLLAIFKS 225

  Fly   172 -----LV-FISSENPDTVFNSIEALHRMLLVQSADQMLDFTTQPDFPVDRIICEVTNEFQEIRKA 230
                 || .:||.....:|.:|..||.:||                            :||..|.
Mouse   226 GGIPALVRMLSSPVESVLFYAITTLHNLLL----------------------------YQEGAKM 262

  Fly   231 ALKTLKTLLADTGDDSVFEALHRCYFVLEQLVKVFCESPQGPE----AADVIEVLATALRSEKMT 291
            |::     |||.               |:::|.:.  :...|:    ..|.:::||   ...:.:
Mouse   263 AVR-----LADG---------------LQKMVPLL--NKNNPKFLAITTDCLQLLA---YGNQES 302

  Fly   292 KLFFEQNLFDQ-VVEQVRNHMDLMPLEMRCTIISIFAETAQYEQFL---PRMHKAEIADMFLTCL 352
            ||....|...| :|:.:||:                    .||:.|   .|:.|.      |:..
Mouse   303 KLIILANGGPQGLVQIMRNY--------------------SYEKLLWTTSRVLKV------LSVC 341

  Fly   353 MQNKPAPAAYVIQ-------GLHRMSHHPE-------ALRRI--VAAYQEG--AIRKLVAILMSP 399
            ..||||    :::       |.|..|:.|.       .||.:  ||..|||  ::.|::...:|.
Mouse   342 PSNKPA----IVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQLSV 402

  Fly   400 DVAIKAREQAGEFLSRLLVAAFRETAAQLQEQDIAVVLTAVIAQG------QPTL---------- 448
            | .:.....|...||.|.....:......|...:..::.|::..|      :|.:
Mouse   403 D-DVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAGDKDDITEPAVCALRHLTSRH 466

  Fly   449 --------SIDLILLLLTIIESLAQKEEY---RTILG---------------EYSSLTEQLAQLL 487
                    |:.|...:..|::.|.|..::   :..:|               :.:::..:|.|||
Mouse   467 PEAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLL 531

  Fly   488 MRSFAHSILVNNIFRCLCTLIDEAPVRETLLANYIVSSMKRALKSLSNLVKTSVTNFILQT-TRF 551
            ::  ||.....::     ....:.|..:.:....||.....||..|:......:..|.|.| ..|
Mouse   532 VK--AHQDAQRHV-----AAGTQQPYTDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLF 589

  Fly   552 NEFIDAYIDR------GIMEVLLDFQKHAFCISTWG---PAIESILSKCPTMKFAIRNCLTFTDI 607
            .:.:.:.::.      |::..|...::.|..|...|   |.:|.:.|         ||..|.| .
Mouse   590 VQLLYSSVENIQRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHS---------RNEGTAT-Y 644

  Fly   608 TAGKDFYVSRRKFEDFRK------FQDILRNDCSPLDA---VLVMNFDRPKPNQNDVIA------ 657
            .|...|.:|..|..|:||      ...:.::|.:..:|   ::.:|    :|..:|:.|
Mouse   645 AAAVLFRISEDKNPDYRKRVSVELTNSLFKHDPAAWEAAQSMIPIN----EPYADDMDATYRPMY 705

  Fly   658 ---VPLRCLSTITDLPGD 672
               |||..|....||.||
Mouse   706 SSDVPLDPLDMHMDLDGD 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13326	NP_610838.1	EDR1	<759..799	CDD:291079
Jup	NP_034723.1	ARM 6	342..381		10/42 (24%)
		armadillo repeat	345..380	CDD:293788	9/38 (24%)
		ARM 7	383..420		11/37 (30%)
		armadillo repeat	393..418	CDD:293788	6/25 (24%)
		ARM 8	423..464		4/40 (10%)
		armadillo repeat	426..464	CDD:293788	4/37 (11%)
		ARM 9	470..510		6/39 (15%)
		armadillo repeat	470..508	CDD:293788	6/37 (16%)
		ARM 10	512..551		7/45 (16%)
		armadillo repeat	515..572	CDD:293788	12/63 (19%)
		Interaction with DSC1. /evidence=ECO:0000250	574..661		21/96 (22%)
		armadillo repeat	577..611	CDD:293788	5/33 (15%)
		armadillo repeat	618..652	CDD:293788	12/43 (28%)
		Adaptin_N	<120..>289	CDD:366724	42/238 (18%)
		Interaction with DSC1 and DSG1. /evidence=ECO:0000250	132..297		43/237 (18%)
		armadillo repeat	144..169	CDD:293788	6/32 (19%)
		armadillo repeat	186..212	CDD:293788	6/35 (17%)
		armadillo repeat	221..253	CDD:293788	10/31 (32%)
		ARM	221..253	CDD:214547	10/31 (32%)
		armadillo repeat	261..297	CDD:293788	11/60 (18%)
		ARM 5	298..341		13/68 (19%)
		armadillo repeat	305..338	CDD:293788	10/58 (17%)
		PLN03200	<328..>658	CDD:215629	68/357 (19%)
		ARM	341..381	CDD:214547	10/43 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2332
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940