DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13325 and nrf-6

DIOPT Version :9

Sequence 1:	NP_001286373.1	Gene:	CG13325 / 36437	FlyBaseID:	FBgn0033792	Length:	697	Species:	Drosophila melanogaster
Sequence 2:	NP_495680.1	Gene:	nrf-6 / 174287	WormBaseID:	WBGene00003813	Length:	822	Species:	Caenorhabditis elegans

Alignment Length:	767	Identity:	185/767 - (24%)
Similarity:	311/767 - (40%)	Gaps:	180/767 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 LGIEFTEYFRNIST-----QDLGGLE---------SQFSSED-DLLCLNDMKAL-MTGL------ 81
            |.::|..:|.|.:.     .:.|.||         .:..|.| .:.|:.||..| .||:
Worm    65 LDLDFFRHFFNYAEAYRDGAEEGNLELMKYAVEMVEKLKSFDISMACVGDMMHLAWTGVEYATHV 129

  Fly    82 ------------------GSAEYWALKMIDAWGSIPSGLLAGNSYDLGNFDEC--LNIRKEIGQE 126
                              .|..:|...:.||.|.:|:|:::||:..:|::..|  :::.|. .|.
Worm   130 EEHKNCSDCKCTPLFQQKKSERHWIFNVFDAMGKVPAGIMSGNNLWVGSWSTCRKIDVVKN-AQG 193

  Fly   127 RTIQGKYCFLSV------SPAKILGIETS------------------------IGSFRTATCFPA 161
            :..:|:||..::      :|....|...|                        ....:...|.|.
Worm   194 QKWKGQYCLATIDAYERDNPLVYFGNMMSGPPDKHCYDKTVKNVTDDGFCFALFPVLKFGVCMPN 258

  Fly   162 SCSAINMNAFVDQLMMKLLNVSVPSSAMRISEGSCQT---------------SDSEPWDALTIFM 211
            :|:    |..|.|::         |.|:|.:||:..|               ||:...:.|.:|.
Worm   259 TCT----NHDVKQML---------SFAIRATEGAVGTKSVCNVDVECRAESYSDAMSENGLAMFA 310

  Fly   212 IVILSLMSFIVALSTLWDYFLV----KDQDQLPA----IVKICSARSNSRALFRVVESHSNPNVI 268
            :.:|.....:|...||:|.|:|    :|:....|    .:|...|.|.......:::|..|...|
Worm   311 LYLLIATVVLVTFGTLYDLFIVSKAPQDEKNSSAFNHPFIKFILAFSMYTNGSEILQSKKNDREI 375

  Fly   269 DCLHGIRCMSLIWVITCHQY-----SVT---LISPHINL---FRAATWVEKPFASFILHGFISVD 322
            :.|||:|.:|:.|:|..|.|     |:|   |:...||.   |.....|:.|.|         ||
Worm   376 NSLHGVRFLSMCWIILGHTYYYIGTSLTTDNLVPTLINFPKQFHTQIIVQAPLA---------VD 431

  Fly   323 SFLVIGGLLVALIPLRLMDKT-------KGKLNV------PMMYLHRLIRIAPLLAMAIVVHMKL 374
            ||..:.|:|.|   .....||       ..||:.      ||.|..|.|||.|...:.::..:.|
Worm   432 SFFFLSGMLAA---FSFFKKTMKADPNHPPKLSAFNWQTWPMYYYKRYIRITPTYIIVMLFDVTL 493

  Fly   375 MPLISSGPLFVGGYIGNSACKAGWYWTLLFVNNY--TDAK-CLAQSWYLSLDMQLYI-ISPILLI 435
            ...||:||.:  ..|....|...|:..|:::||:  .|.: |:..:|||:.|||.:| :.|:|:|
Worm   494 FTYISNGPFW--RPIERQGCSIAWWTNLIYLNNFLLQDQECCMGWTWYLANDMQFHIFLMPLLVI 556

  Fly   436 SLYKWGKKAAAGIFILIILLSACL-FATMMVNGY--------SMMITAASPEAMRDGYYATHTHA 491
            ...|||.|...|:...:|.||:.: .....:.||        .:.|.....:...|.|...:...
Worm   557 VFLKWGMKVGLGLSTGLIALSSLIRLIITQIYGYPPAPILTAKLQIVYQLNDYWNDVYVRPYIRC 621

  Fly   492 TPWLIGFLFGYFLHL-----NRGKKFQLSWVSVWSGWILCLAMIFTSIFALYPPSKW--SDPDAS 549
            ||:::|.:..|.|:.     .:..|.:|...:|...|.....:...|:|.||    |  ...|.|
Worm   622 TPFIVGIVVAYLLNAWTTREQKDLKIKLERRTVIICWCTSTVLGLYSVFGLY----WFAKTGDIS 682

  Fly   550 TLAESFYYTLTRVGWALALCWVIFACVQGYGGLANSFLASPLWQPLSRLSYSVFIWHMFFMEMNA 614
            ...|..|.......:||||.||:|||..|.||..::.|:..|:.|||::::..::.|...:::..
Worm   683 KPWEILYTIFGTPAYALALGWVVFACTTGNGGPVDTILSWRLFVPLSKITFCAYLLHPIMLQIYN 747

  Fly   615 RSTRTSTYFSDYGMMLNFWSTL-----GFTLLFSYAMHLLIEAPIGGLDIFL 661
            .|.....:|:.:..|:.:  |:     .:|:.|.::  |..|.|:..:|..|
Worm   748 LSRPQPFHFTTFIQMIRY--TVEAVFASYTIAFFFS--LAFEKPLNKIDEML 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13325	NP_001286373.1	NRF	85..198	CDD:214781	29/144 (20%)
		Acyl_transf_3	268..648	CDD:280013	116/428 (27%)
		OafA	299..654	CDD:224748	103/395 (26%)
nrf-6	NP_495680.1	NRF	151..288	CDD:214781	30/150 (20%)
		OafA	375..790	CDD:224748	119/436 (27%)
		Acyl_transf_3	375..777	CDD:280013	115/421 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162772
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3700
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171418at2759
OrthoFinder	1	1.000	-	-		FOG0001682
OrthoInspector	1	1.000	-	-		otm14368
orthoMCL	1	0.900	-	-		OOG6_100705
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X299
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.650