DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Drl-2 and RYK

DIOPT Version :9

Sequence 1:NP_001286371.1 Gene:Drl-2 / 36436 FlyBaseID:FBgn0033791 Length:648 Species:Drosophila melanogaster
Sequence 2:NP_001005861.1 Gene:RYK / 6259 HGNCID:10481 Length:610 Species:Homo sapiens


Alignment Length:695 Identity:216/695 - (31%)
Similarity:340/695 - (48%) Gaps:164/695 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MELLPL---------KSPLPILLLCLTISTSVSGYLNIFISHHEVMKLMGLEADLFYVHEGAINT 56
            :.||||         .:|.|..|...:...|||    :::|..||.:|:||:|:|:||....|:.
Human    33 LALLPLLPAPGAAAAPAPRPPELQSASAGPSVS----LYLSEDEVRRLIGLDAELYYVRNDLISH 93

  Fly    57 YAMHFTVPVPADVHELEFSW--QSLIAYPLPYAISIEYNNDQEALGTPTLSIPHKGLVPQEIESF 119
            ||:.|::.||::.:.|.|:|  :|.:.|.|.:.:     ::..|:..|.::|..:|.||:.:..|
Human    94 YALSFSLLVPSETNFLHFTWHAKSKVEYKLGFQV-----DNVLAMDMPQVNISVQGEVPRTLSVF 153

  Fly   120 LVYLPCTG--NASLQMPVNVNMVVRAPPRFNDTRLHFKRNKICAKGISP------EPNQSPA--- 173
            .|.|.|||  ::.:.:.:.:|:.|.:...|  |.|:|||.|:|.|.:..      :.|.|..   
Human   154 RVELSCTGKVDSEVMILMQLNLTVNSSKNF--TVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYD 216

  Fly   174 PAH-APSQGPAL--LSAAACALGLVLAVGLVASMMYVRARKQLRQDSLHTSFTTAAYGSHQNVFI 235
            |.| ||:....:  :|...|. .::..|.::.:::::.:.|::..|                   
Human   217 PVHAAPTTSTRVFYISVGVCC-AVIFLVAIILAVLHLHSMKRIELD------------------- 261

  Fly   236 RLDPLGRPPSATGSYATIASLNKYPADSKKSCSIFDRFRSSPTPTPYATALLPMNLEQTAETIYS 300
                                      ||                                     
Human   262 --------------------------DS------------------------------------- 263

  Fly   301 KPESICPSRISYYASSQ-LTQPCSLSTPKSIRSNGNGNCTSGSGSLSLFGGIPTGSTITMASHGE 364
                     ||..:||| |:|| |..|.:.:|::...|.|..:.||    |.||       ...|
Human   264 ---------ISASSSSQGLSQP-STQTTQYLRADTPNNATPITSSL----GYPT-------LRIE 307

  Fly   365 KGNQRLRRIT------SVQPGALSYE-----ELVKEGTFGRIYAGKL------GESCEALVKTVI 412
            |.:  ||.:|      .|:..|:|.|     ::::|||||||:.|.|      .:..:|.||||.
Human   308 KND--LRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVK 370

  Fly   413 DGASLTQVACLLQDASLLIGVSHQHILAPLLANTELPGPPEIAYPHPSKGNLKMYLQKSR----E 473
            |.||..||..:|.::..|.|:.|:::|.......|....|.:..|:.:.||||::|::.:    .
Human   371 DQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKLVEAN 435

  Fly   474 SSTALSTRQLVEFGLHITKGLAYLHSLGIVHKDIATRNCYLDEESYVKICDSALSRDLFPDDYDC 538
            :..|:|.:.||...:.|..|::||....::|||:|.|||.:|:...|||.|:||||||||.||.|
Human   436 NPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHC 500

  Fly   539 LGDNENRPLKWLSLESLQKRVYATQGDVWALGVTYWELVTLAQMPHEEVDIFELTNYLAAGFRLE 603
            ||||||||::|::||||....:::..||||.|||.|||:||.|.|:.::|.||:..||..|:|:.
Human   501 LGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIA 565

  Fly   604 QPVNCPDEFFTVMNCCWHCEAKQRPTPSQLLSYLQDFHADLGMYI 648
            ||:|||||.|.||.|||..:.::||...||:..|.:|||.||.|:
Human   566 QPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFHAALGAYV 610

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Drl-2NP_001286371.1 WIF 37..156 CDD:280237 37/122 (30%)
PTK_Ryk 373..644 CDD:270639 123/291 (42%)
STYKc 389..637 CDD:214568 114/257 (44%)
RYKNP_001005861.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
WIF 63..196 CDD:128745 47/143 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 266..290 9/24 (38%)
PTK_Ryk 326..606 CDD:270639 121/279 (43%)
Pkinase_Tyr 333..599 CDD:285015 114/265 (43%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 87 1.000 Domainoid score I7992
eggNOG 1 0.900 - - E1_KOG1025
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H68287
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S3376
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D359098at33208
OrthoFinder 1 1.000 - - FOG0005256
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24416
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X3777
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
109.870

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