DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Drl-2 and Erbb4

DIOPT Version :9

Sequence 1:	NP_001286371.1	Gene:	Drl-2 / 36436	FlyBaseID:	FBgn0033791	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_067719.2	Gene:	Erbb4 / 59323	RGDID:	620486	Length:	1308	Species:	Rattus norvegicus

Alignment Length:	303	Identity:	85/303 - (28%)
Similarity:	144/303 - (47%)	Gaps:	36/303 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   363 GEKGNQRLRRITSVQPGALSYEELVKEGTFGRIYAG---------KLGESCEALVKTVIDGASLT 418
            |...||...||  ::...|...:::..|.||.:|.|         |:..:.:.|.:|....|::.
  Rat   702 GTAPNQAQLRI--LKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVE 764

  Fly   419 QVACLLQDASLLIGVSHQHI-------LAPLL-ANTELPGPPEIAYPHPSKGNLKMYLQKSRESS 475
                .:.:|.::..|.|.|:       |:|.: ..|:|       .||   |.|..|:.:.:::
  Rat   765 ----FMDEALIMASVDHPHLVRLLGVCLSPTIQLVTQL-------MPH---GCLLEYVHEHKDN- 814

  Fly   476 TALSTRQLVEFGLHITKGLAYLHSLGIVHKDIATRNCYLDEESYVKICDSALSRDLFPDDYDCLG 540
              :.::.|:.:.:.|.||:.||....:||:|:|.||..:...::|||.|..|:|.|..|:.:...
  Rat   815 --IGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNA 877

  Fly   541 DNENRPLKWLSLESLQKRVYATQGDVWALGVTYWELVTLAQMPHEEVDIFELTNYLAAGFRLEQP 605
            |....|:||::||.:..|.:..|.|||:.|||.|||:|....|::.:...|:.:.|..|.||.||
  Rat   878 DGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQP 942

  Fly   606 VNCPDEFFTVMNCCWHCEAKQRPTPSQLLSYLQDFHADLGMYI 648
            ..|..:.:.||..||..:|..||...:|.:.......|...|:
  Rat   943 PICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYL 985

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drl-2	NP_001286371.1	WIF	37..156	CDD:280237
		PTK_Ryk	373..644	CDD:270639	79/287 (28%)
		STYKc	389..637	CDD:214568	77/264 (29%)
Erbb4	NP_067719.2	Recep_L_domain	55..167	CDD:395817
		Furin-like	186..332	CDD:395614
		Recep_L_domain	358..478	CDD:395817
		GF_recep_IV	502..634	CDD:405525
		TM_ErbB4	642..685	CDD:213053
		Nuclear localization signal. /evidence=ECO:0000250	676..684
		PTKc_HER4	710..1012	CDD:173655	82/295 (28%)
		PPxy motif 1	1032..1035
		PPxY motif 2	1298..1301
		PDZ-binding	1306..1308
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900