DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Drl-2 and Ret

DIOPT Version :9

Sequence 1:	NP_001286371.1	Gene:	Drl-2 / 36436	FlyBaseID:	FBgn0033791	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_477044.1	Gene:	Ret / 43875	FlyBaseID:	FBgn0011829	Length:	1235	Species:	Drosophila melanogaster

Alignment Length:	284	Identity:	86/284 - (30%)
Similarity:	141/284 - (49%)	Gaps:	17/284 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   381 LSYEELVKEGTFGRIYAGKLGESC------EALVKTVIDGASLTQVACLLQDASLLIGVSHQHIL 439
            |..:.::.||.||::..|...|..      ...||.:..|::..:...||.:..||..|||.:::
  Fly   771 LQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVSHPNVI 835

  Fly   440 APLLANTELPGPPEIAYPHPSKGNLKMYLQKSRESSTA----------LSTRQLVEFGLHITKGL 494
            ..|.|.|.... |.:...:...|:|:.||:.||:...|          ::.:.::.|...|.||:
  Fly   836 KLLGACTSSEA-PLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTFAWQICKGM 899

  Fly   495 AYLHSLGIVHKDIATRNCYLDEESYVKICDSALSRDLFPDDYDCLGDNENRPLKWLSLESLQKRV 559
            |||..|.:||:|:|.||..|.:....||.|..|:||::.||.......:..|:||::.|||...|
  Fly   900 AYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHV 964

  Fly   560 YATQGDVWALGVTYWELVTLAQMPHEEVDIFELTNYLAAGFRLEQPVNCPDEFFTVMNCCWHCEA 624
            |.::.|||:.||..|||:||...|:..:....|.:.|..|:|:::|.||.:..::::..||..|.
  Fly   965 YTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEP 1029

  Fly   625 KQRPTPSQLLSYLQDFHADLGMYI 648
            ..||:...|.|..:....:...||
  Fly  1030 NGRPSFKFLASEFEKLLGNNAKYI 1053

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drl-2	NP_001286371.1	WIF	37..156	CDD:280237
		PTK_Ryk	373..644	CDD:270639	84/278 (30%)
		STYKc	389..637	CDD:214568	83/263 (32%)
Ret	NP_477044.1	PKc_like	770..1049	CDD:304357	84/278 (30%)
Ret	NP_477044.1	TyrKc	771..1042	CDD:197581	84/271 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010