DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Drl-2 and Eph

DIOPT Version :9

Sequence 1:	NP_001286371.1	Gene:	Drl-2 / 36436	FlyBaseID:	FBgn0033791	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster

Alignment Length:	654	Identity:	135/654 - (20%)
Similarity:	244/654 - (37%)	Gaps:	164/654 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 SVSGYLNIFISHHEVMKLMGLEADLFYVHEGAINTYAMHFTVPVPADVHELEFSWQSLIAYPLPY 86
            ||| ::|.|..|.....|:.: :|:.:.:...:|         :|.|::|::.....::......
  Fly   476 SVS-HINEFKRHSNESSLVAV-SDIVFSNTSLLN---------IPLDLNEVKTGQAEIVFTTESV 529

  Fly    87 AISIEYNNDQEALGTPTLSIPHKGLVPQEIESFLVYLPCTGNASLQ--MPVNVNMVVRAPPRFND 149
            .:|..:|       ...|:|.:|                  :|.|:  .||..:.    |..|.:
  Fly   530 LLSTVFN-------LRILAITNK------------------DADLEWDKPVQSDF----PLEFYE 565

  Fly   150 TRLHFKRNKICAKGISPEPNQSPAPAHAPSQGPALLSAAACALGLVLAVGLVASMMY---VRARK 211
            .| .|.:.::.|...| ..|.....||                    .|||:.:..|   ||.:
  Fly   566 VR-WFPKVELDAINKS-ALNTKETKAH--------------------IVGLLENTEYGFQVRCK- 607

  Fly   212 QLRQDSLHTSFTTAAYGSHQNVFIRLDPLGRPPSATGSYA-TIASLNKYPADSKK---------- 265
                       |...:||:.|:.               || |:.|:.....||.:
  Fly   608 -----------TNNGFGSYSNMI---------------YAQTLQSVGSVYDDSVQIRFIAGAIVT 646

  Fly   266 ----------SCSIFDRFRSSPTPTPYATALLPMNLEQTAETIYSKPESICPSRISYYASSQLTQ 320
                      :...|.|.:........:|..||:.|:                    |||:::..
  Fly   647 GVLFLVIFIIATVYFMRSKHQDDLDKKSTNHLPLPLD--------------------YASNEVNS 691

  Fly   321 PCSLSTPKSIRSNGNGNCTSGSGSLSLFGGIPTGSTITMASHG-EKGNQRLRRIT-SVQPGALSY 383
            ..:....|.:..|         .:..|||    .|...:..|. |..||.:|... .:....::.
  Fly   692 MDTTPIVKKLHLN---------VTTPLFG----NSRSYVDPHTYEDPNQAIREFAREIDANYITI 743

  Fly   384 EELVKEGTFGRIYAGKLG------ESCEALVKTVIDGASLTQVACLLQDASLLIGVSHQHILAPL 442
            |.::..|.||.:..|:|.      :..:..:||:..|:|.......|.:||::....|.:::. |
  Fly   744 EAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIY-L 807

  Fly   443 LANTELPGPPEIAYPHPSKGNLKMYLQKSRESSTALSTRQLVEFGLHITKGLAYLHSLGIVHKDI 507
            ........|..|...:...|:|..:|   |.:.....|.||:.....|..|::||..:..||:|:
  Fly   808 QGVVTRSNPVMIITEYMENGSLDTFL---RVNDGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDL 869

  Fly   508 ATRNCYLDEESYVKICDSALSRDL--FPDDYDCLGDNENRPLKWLSLESLQKRVYATQGDVWALG 570
            |.||..::.:...||.|..|||::  ..|.|...|.  ..|::|.:.|::..|.:.:..|||:.|
  Fly   870 AARNVLVNAQLICKIADFGLSREIENASDAYTTRGG--KIPVRWTAPEAIAFRKFTSASDVWSYG 932

  Fly   571 VTYWELVTLAQMPHEEVDIFELTNYLAAGFRLEQPVNCPDEFFTVMNCCWHCEAKQRPTPSQLLS 635
            |..||:::..:.|:......::...:..|:||..|::||:..:.:|..||..:...|||.:.::|
  Fly   933 VVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVS 997

  Fly   636 YLQD 639
            .|.:
  Fly   998 TLDN 1001

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drl-2	NP_001286371.1	WIF	37..156	CDD:280237	19/120 (16%)
		PTK_Ryk	373..644	CDD:270639	69/276 (25%)
		STYKc	389..637	CDD:214568	67/255 (26%)
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439
		FN3	387..476	CDD:238020	135/654 (21%)
		FN3	536..623	CDD:238020	29/164 (18%)
		EphA2_TM	644..736	CDD:291255	20/124 (16%)
		PTKc_EphR	736..1002	CDD:270629	69/272 (25%)
		Pkinase_Tyr	741..999	CDD:285015	68/263 (26%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010