Protein Alignment Drl-2 and btl

DIOPT Version :10

• Sequence 1: NP_610835.2
• Gene: Drl-2 / 36436
• FlyBaseID: FBgn0033791
• Length: 648
• Species: Drosophila melanogaster
• Sequence 2: NP_729956.1
• Gene: btl / 39564
• FlyBaseID: FBgn0285896
• Length: 1052
• Species: Drosophila melanogaster
• Alignment Length: 718
• Identity: 169/718 - (23%)
• Similarity: 275/718 - (38%)
• Gaps: 187/718 - (26%)

  Fly    66 PADVHELEFSWQSLIAYPLPYAISIEYNNDQ------EALGTPTLSIPHKGLVPQEIESFLVYLP 124
            |:|...:..:..:.:|.|:|.|.:.|.|:|.      ||.|         |:.|......|
  Fly   349 PSDTTTVRTTTTTTVASPIPTASTGEDNDDDVENPAAEASG---------GVGPPVFRKEL---- 400

  Fly   125 CTGNASLQMPVNVNMVVRAPPRFNDTRLHFKRNKICAK---GISPEPNQSPAPAHAPSQGPALLS 186
                ..||..::.|.|..|.|.:....:.:.::|....   |:..:.|.:.....|.|:...|.:
  Fly   401 ----KRLQHSLSGNTVNLACPVYGKANITWTKDKKPLNRELGVYVQKNWTLRFVEATSEDSGLYN 461

  Fly   187 AAAC-ALGLV--------------LAVGLVASMMYVRA---------------------RKQLRQ 215
            ...| |.|.:              ..:.:|.....|:.                     |..|:.
  Fly   462 CKVCNAWGCIQFDFSVQINDRTRSAPIIVVPQNQTVKVNGSLVMKCTVYSDLHPTVSWKRVVLKN 526

  Fly   216 DSL---------HTSFTTAAYGSHQNVFIRLDPLGRPPSAT----GSYATIASLNKYPADSKKSC 267
            .||         :.:||.    ::.:|.:.|      .:.|    |.|..:||...    .:.:.
  Fly   527 ASLDGLKSVEIQNLNFTV----TNDSVVLTL------RNVTFDQEGWYTCLASSGL----GRSNS 577

  Fly   268 SIFDRFRSSPTPTPYATALL---PMNLEQTAETIYS----------------KPESICPSRISYY 313
            |::.|. .||.|.....|||   |:.....|.||.:                :.|.:...||.
  Fly   578 SVYLRV-VSPLPPLEIYALLHAHPLGFTLAAITIVALFLLGSAFITFMLRRLRREKLLKLRIE-- 639

  Fly   314 ASSQLTQPCSLSTPKSIRSNGNGNCTSGS------------GSLSLFGGIPTGSTITMASHGE-- 364
            ...|.|:...:..|.....:|   |:||.            .::|..|   ||.|.......|
  Fly   640 TVHQWTKKVIIYRPGGEEGSG---CSSGDLQMPVIRIEKQRTTVSTTG---TGGTDPAQGFNEYE 698

  Fly   365 ---KGNQRLRRITSVQPGALSYEELVKEGTFGRIY---------AGKLGESCEALVKTVIDGASL 417
               ..|..:.|      ..||...::.||.|||:.         :.:|.|:..| ||.|.:..:.
  Fly   699 FPLDSNWEIPR------QQLSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVA-VKMVKEEHTD 756

  Fly   418 TQVACLLQDASL--LIGVSHQHI-LAPLLANTELPGPPEIAYPHPSKGNLKMYLQKSRE------ 473
            |.:|.|:::..:  :||   :|| :..||......||..:...:...||||.:|:::|.
  Fly   757 TDMASLVREMEVMKMIG---KHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNRPGAPQRR 818

  Fly   474 -------------SSTALSTRQLVEFGLHITKGLAYLHSLGIVHKDIATRNCYLDEESYVKICDS 525
                         |:..|..::|.:|...|.:|:.||.|...:|:|:|.||..:.:...:||.|.
  Fly   819 SDSDGYLDDKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADF 883

  Fly   526 ALSRDLFPDDYDCLGDNENRPLKWLSLESLQKRVYATQGDVWALGVTYWELVTLAQMPHEEV-DI 589
            .|:||:...:|.....|...|:||::.||||::.|.:|.|||:.||..||::|....|:..: ..
  Fly   884 GLARDIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSA 948

  Fly   590 FELTNYLAAGFRLEQPVNCPDEFFTVMNCCWHCEAKQRPTPSQLL-----------SYLQDFHAD 643
            .||.:||..|.|:|:|..|....:.||..|||.|:..|||.::|:           |...|.:.|
  Fly   949 EELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDGILQQASSNPNDAYLD 1013

  Fly   644 LGM 646
            |.|
  Fly  1014 LSM 1016

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Drl-2	NP_610835.2	WIF	30..156	CDD:460414	21/95 (22%)
		PTK_Ryk	373..644	CDD:270639	91/313 (29%)
btl	NP_729956.1	Ig	143..215	CDD:472250
		Ig strand B	160..164	CDD:409570
		Ig strand C	175..179	CDD:409570
		Ig strand E	197..201	CDD:409570
		Ig strand F	211..215	CDD:409570
		Ig_3	247..333	CDD:464046
		Ig	398..479	CDD:472250	16/88 (18%)
		Ig strand B	412..416	CDD:409393	1/3 (33%)
		Ig strand C	423..427	CDD:409393	0/3 (0%)
		Ig strand E	445..449	CDD:409393	0/3 (0%)
		Ig strand F	459..464	CDD:409393	1/4 (25%)
		Ig strand G	472..475	CDD:409393	0/2 (0%)
		IG_like	492..583	CDD:214653	15/104 (14%)
		Ig strand B	503..507	CDD:409444	0/3 (0%)
		Ig strand C	516..520	CDD:409444	0/3 (0%)
		Ig strand E	549..553	CDD:409444	1/3 (33%)
		Ig strand F	563..568	CDD:409444	1/4 (25%)
		Ig strand G	576..579	CDD:409444	0/2 (0%)
		Protein Kinases, catalytic domain	700..1000	CDD:473864	91/309 (29%)