DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Drl-2 and Tie

DIOPT Version :9

Sequence 1:	NP_001286371.1	Gene:	Drl-2 / 36436	FlyBaseID:	FBgn0033791	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster

Alignment Length:	613	Identity:	129/613 - (21%)
Similarity:	212/613 - (34%)	Gaps:	203/613 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 GISPEPNQSPAPAHAPSQGPALLSAAACALGLVLAVGLVASMMYVRARKQLRQDSLHTSFTTAAY 227
            |::|.....  |:|.....|.:|...        .:..:.|.::.|.    ...|..||.||.|
  Fly   631 GVTPRTQTQ--PSHTTDSSPKILRTT--------VLTSIRSTVHPRP----TSTSTTTSTTTTA- 680

  Fly   228 GSHQNVFIRLDPLGRPPSATGS----YATI--ASLNKYPAD-------SKKSCSIFDRFRSSPTP 279
                           ||:.|..    |..|  :|.:..|||       :::..::..|..:..|.
  Fly   681 ---------------PPAVTAPSNEVYIGIVESSSSASPADISSTVIANERDLNMEMRRMNLVTL 730

  Fly   280 TPYATALLPM-----------------NLEQTAETIYSKPESICP-------------------- 307
            ...|..::|:                 ...:..:...:..:.|.|
  Fly   731 VLVAVGVIPLAAIILYLVRNFVIRRRAKQSEVFDVCITDQQPISPVKKVDSKYQVDDDEDEVDHQ 795

  Fly   308 --SRISYYASSQLTQ--------PCSLSTPKSIRSNGNGNCTSGSGSLSLFGGIPTGSTITMASH 362
              ..:.::.:.|..|        |.|.::.:....|..||....:...|.|...
  Fly   796 HHQHMQHHQNHQNHQNHQHHQAMPMSQASQRDANHNRYGNNDDKTSLASEFHDF----------- 849

  Fly   363 GEKGNQRLRRITSVQPGALSYEELVKEGTFGRIY-------AGKLGESCEALVKTVIDGASLTQV 420
             |:.|.||:             .|:.||.||:::       :|..|.:....|||:  .|...||
  Fly   850 -ERSNIRLK-------------SLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTI--RACSAQV 898

  Fly   421 ACLLQDASLL--IGVSHQHILAPLLANTELPGPPEIAYPHPSKGNLKMYLQKSR----------- 472
            : |..:|:::  :| |||:::..|.|..| ..|..:...:..:|.|...|:.:|
  Fly   899 S-LKDEANIMRKLG-SHQNVVTLLGACVE-SEPHMLIMEYAMRGRLLSLLRAARSATNILPASVP 960

  Fly   473 --ESSTALSTRQLVEFGLHITKGLAYLHSLGIVHKDIATRNCYLDEESYVKICDSALSRDL---- 531
              .|...||.|.|..|.|.|..|:.|:....|||:|:|.||..||.....||||..:|.||
  Fly   961 GGRSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAER 1025

  Fly   532 --------------------FPDDY-------------------------------------DCL 539
                                |..|:                                     |.:
  Fly  1026 MRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTI 1090

  Fly   540 GDNENRPLKWLSLESLQKRVYATQGDVWALGVTYWELVTLAQMPHEEVDIFELTNYLAAGFRLEQ 604
            |.....|::|::.||||..::.|:.|:||.|:..||:.||...|:.::...|:...:..|.|.:.
  Fly  1091 GKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDL 1155

  Fly   605 PVNCPDEFFTVMNCCWHCEAKQRPTPSQ 632
            |.....||:.:|:.|||.|...||:.:|
  Fly  1156 PKESRHEFYNLMSRCWHKEPHMRPSFAQ 1183

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drl-2	NP_001286371.1	WIF	37..156	CDD:280237
		PTK_Ryk	373..644	CDD:270639	87/343 (25%)
		STYKc	389..637	CDD:214568	86/327 (26%)
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	88/346 (25%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	86/329 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100