DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Drl-2 and Nrk

DIOPT Version :9

Sequence 1:	NP_001286371.1	Gene:	Drl-2 / 36436	FlyBaseID:	FBgn0033791	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_477255.1	Gene:	Nrk / 36445	FlyBaseID:	FBgn0020391	Length:	724	Species:	Drosophila melanogaster

Alignment Length:	356	Identity:	99/356 - (27%)
Similarity:	160/356 - (44%)	Gaps:	53/356 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   319 TQPCSLSTPK-SIRSNGNGNC-----TS-----GSG---SLSLFGGIPTGSTI------------ 357
            :||...:|.: |:...|.|:|     ||     |:|   :|:.:|.|.:.:||
  Fly   354 SQPAGAATAECSVSMRGGGDCGGNLNTSRETLGGNGNTNTLAKWGTIRSTATIHSNCVALTTVTN 418

  Fly   358 TMASHGEKGNQRLRRITSVQPGALSYEELVKEGTFGRIYAGKL------GESCEALVKTVIDGAS 416
            ...:.|.|.|.||.:: ....|.:.|...:.:|.|||::..:.      .|.....||.:.|.||
  Fly   419 VSDAKGTKPNARLEKL-EYPRGDIVYVRSLGQGAFGRVFQARAPGLVPDQEDLLVAVKMLKDDAS 482

  Fly   417 LTQVACLLQDASLLIGVSHQHILAPLLANTELPGPPEIAYPHPSKGNLKMYL---------QKSR 472
            ........::|.||....|.:|:. ||....|..|..:.:.:.:.|:|..:|         |...
  Fly   483 DQMQMDFEREACLLAEFDHPNIVR-LLGVCALGRPMCLLFEYMAPGDLSEFLRACSPYATHQAPT 546

  Fly   473 ESSTALSTRQLVEFGLHITKGLAYLHSLGIVHKDIATRNCYLDEESYVKICDSALSRDLFPDDYD 537
            :....|:...|::...:|..|:.||.....||:|:|||||.::|...|||.|..||..::..||.
  Fly   547 QDRLQLNELHLLQMAANIAAGMLYLSERKFVHRDLATRNCLINEHMAVKIADFGLSHKIYLQDYY 611

  Fly   538 CLGDNENRPLKWLSLESLQKRVYATQGDVWALGVTYWELVTLAQMP-----HEEVDIFELTNYLA 597
            ...:|:..|::|:.|||:....::.:.||||.|:..||:.:.|..|     ||||     ..|:.
  Fly   612 KGDENDFIPIRWMPLESILYNKFSLESDVWAYGICLWEVFSFALQPYFGLTHEEV-----IKYIK 671

  Fly   598 AGFRLEQPVNCPDEFFTVMNCCWHCEAKQRP 628
            .|..|..|.|.|...:.:|..||:.:..:||
  Fly   672 EGNVLGCPDNTPLSVYALMRRCWNRKPSERP 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drl-2	NP_001286371.1	WIF	37..156	CDD:280237
		PTK_Ryk	373..644	CDD:270639	78/276 (28%)
		STYKc	389..637	CDD:214568	76/260 (29%)
Nrk	NP_477255.1	CRD_FZ	67..212	CDD:295308
		KR	217..299	CDD:214527
		PTKc_Musk	435..713	CDD:133181	78/274 (28%)
		Pkinase_Tyr	441..707	CDD:285015	77/268 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010