Protein Alignment Drl-2 and dnt

DIOPT Version :10

• Sequence 1: NP_610835.2
• Gene: Drl-2 / 36436
• FlyBaseID: FBgn0033791
• Length: 648
• Species: Drosophila melanogaster
• Sequence 2: NP_477341.2
• Gene: dnt / 35207
• FlyBaseID: FBgn0024245
• Length: 584
• Species: Drosophila melanogaster
• Alignment Length: 655
• Identity: 225/655 - (34%)
• Similarity: 331/655 - (50%)
• Gaps: 112/655 - (17%)

  Fly     8 SPLPILLLCLTISTSVSGYLNIFISHHEVMKLMGLEADLFYVHEGAINTYAMHFTVPVPADVHEL 72
            |.|.:..|.|...:.|:.:||:|::..|||:|:|:.|:::||.||.||.||::|.|||||:|.::
  Fly    28 SLLALAALQLHSGSEVAAHLNVFLNPVEVMRLLGVSAEVYYVREGHINNYALNFIVPVPANVKDI 92

  Fly    73 EFSWQSLIAYPLPYAISIEYNNDQEALGTPTLSIPHKGLVPQEIESFLVYLPCTGNASLQMPVNV 137
            .|:||||....|||:|:: .::|||.|..|.:::.|.|.:|..|:::.:.|.|:|..:.::.|.|
  Fly    93 SFTWQSLAGRGLPYSINV-VSSDQEVLPRPAINVSHSGEIPTTIQTWSIALKCSGLKAAEVDVTV 156

  Fly   138 NMVVRAPPRFND-TRLHFKRNKICAKGISPEPNQSPAPAHAPSQGPALLSAA--------ACALG 193
            ::.|......|: |.|.|:|.|||..      |.|..........|.||...        ...:|
  Fly   157 SLEVVLNRSLNNVTHLVFRRKKICLM------NDSAEDLSEDVDDPQLLETVMLPPTGLITLVVG 215

  Fly   194 LVLAVGLVASMMY----VRARKQLRQDSLHTSFTTAAYGSHQNVFIRLDPLGRPPSATGSYATIA 254
            :.:|:|.|..::.    |:.....||...|                     |..|..|.|:   .
  Fly   216 VSVAMGSVCLLLMIAYCVKGAANKRQHHQH---------------------GGQPMRTSSF---Q 256

  Fly   255 SLNKYPADSKKSCSIFDRFRSSPTPTPYATALLPMNLEQTAETIYSKPESICPSRISYYASSQLT 319
            .||.:|     .|      :||.....|.|                      ||.|:....|.|.
  Fly   257 RLNTHP-----PC------QSSMGSAAYMT----------------------PSIIAPIHGSSLP 288

  Fly   320 QPCSLSTPKSIRSNGNGNCTSGSGSLSLFGGIPTGSTITMASHGEKGNQRLRRITSVQPGALSYE 384
            :    ..|.|:..                            .|.|:.::|:..:| |:...:...
  Fly   289 R----KVPVSVEQ----------------------------QHPEELHRRISELT-VERCRVRLS 320

  Fly   385 ELVKEGTFGRIYAGKLGESCEALVKTVIDGASLTQVACLLQDASLLIGVSHQHILAPLLANTELP 449
            .|::||||||:|.|...::.:.|||||...||..||..|||:..||.|.||..||:.|..:.|..
  Fly   321 SLLQEGTFGRVYRGTYNDTQDVLVKTVAQHASQMQVLLLLQEGMLLYGASHPGILSVLGVSIEDH 385

  Fly   450 GPPEIAYPH-PSKGNLKMYLQKSRESSTALSTRQLVEFGLHITKGLAYLHSLGIVHKDIATRNCY 513
            ..|.:.||. .:..|||.:|.....:.| ::|.|:|.....::..|.:|||.|:||||||||||.
  Fly   386 TTPFVLYPALNNTRNLKQFLLDPACART-VTTIQIVMMASQLSMALDHLHSHGVVHKDIATRNCV 449

  Fly   514 LDEESYVKICDSALSRDLFPDDYDCLGDNENRPLKWLSLESLQKRVYATQGDVWALGVTYWELVT 578
            :|::..||:.||:|||||||.||:||||:||||:||:|||:||.:.::...|.||.||..|||.|
  Fly   450 IDDQLRVKLSDSSLSRDLFPSDYNCLGDSENRPVKWMSLEALQHKQFSEASDSWAFGVLMWELCT 514

  Fly   579 LAQMPHEEVDIFELTNYLAAGFRLEQPVNCPDEFFTVMNCCWHCEAKQRPTPSQLLSYLQDFHAD 643
            .|:.|:.|||.||:.:||..|:||.||.|||||.||:|..||.....:|||.:||.|.|.:|::.
  Fly   515 SAKQPYAEVDPFEMEHYLKDGYRLAQPFNCPDELFTIMAYCWALLPAERPTFAQLQSCLSEFYSQ 579

  Fly   644 LGMYI 648
            :..|:
  Fly   580 ITRYV 584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Drl-2	NP_610835.2	WIF	30..156	CDD:460414	50/126 (40%)
		PTK_Ryk	373..644	CDD:270639	128/271 (47%)
dnt	NP_477341.2	WIF	46..182	CDD:128745	56/136 (41%)
		Protein Kinases, catalytic domain	310..580	CDD:473864	128/271 (47%)