DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Drl-2 and Erbb3

DIOPT Version :9

Sequence 1:	NP_001286371.1	Gene:	Drl-2 / 36436	FlyBaseID:	FBgn0033791	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_058914.2	Gene:	Erbb3 / 29496	RGDID:	69323	Length:	1339	Species:	Rattus norvegicus

Alignment Length:	691	Identity:	155/691 - (22%)
Similarity:	255/691 - (36%)	Gaps:	169/691 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LNIFISHHEVMKLMGLEADLFYVHEGAINTYAMHFTVPVPADVHELEFSWQSLIA----YPLPYA 87
            ||:|.:..|:...:.:::...::|         :|:|          ||..:.|.    |...::
  Rat   384 LNVFRTVREITGYLNIQSWPPHMH---------NFSV----------FSNLTTIGGRSLYNRGFS 429

  Fly    88 ISIEYNNDQEALGTPTLSIPHKGLVPQEIESFLVYLPCTGNASLQMPVNVNMVVRAPPRFNDTRL 152
            :.|..|.:..:||..:|         :||.:..||:...........:|...::|.|   ::.||
  Rat   430 LLIMKNLNVTSLGFRSL---------KEISAGRVYISANQQLCYHHSLNWTRLLRGP---SEERL 482

  Fly   153 HFKRNK----ICAKGISPEPNQSPAPAHAPSQGPALLSAAACALGLVLAVGLVASMMYVRARKQL 213
            ..|.::    ..|:|...:|..|......|..|..|    :|                   |...
  Rat   483 DIKYDRPLGECLAEGKVCDPLCSSGGCWGPGPGQCL----SC-------------------RNYS 524

  Fly   214 RQD--SLHTSFTTAAYGS--HQNVFIRLDPLGRPPSATGSYATIASLNKYPADSKKSCSIFDRFR 274
            |:.  ..|.:|.......  |:.......|...|...|      ::.|...:|:...|:   .||
  Rat   525 REGVCVTHCNFLQGEPREFVHEAQCFSCHPECLPMEGT------STCNGSGSDACARCA---HFR 580

  Fly   275 SSPTPTPYATALLPMNLEQTAETIYSKPESICPSRISYYASSQLTQPCSLSTPKSIRSNGNGNCT 339
            ..    |:.....|..:......||..|:           :....:||            :.|||
  Rat   581 DG----PHCVNSCPHGILGAKGPIYKYPD-----------AQNECRPC------------HENCT 618

  Fly   340 SGSGS------------------------------LSLFGG-------------------IPTGS 355
            .|...                              |.:.||                   :..|.
  Rat   619 QGCNGPELQDCLGQAEVLMSKPHLVIAVTVGLAVILMILGGSFLYWRGRRIQNKRAMRRYLERGE 683

  Fly   356 TITMASHGEKGNQRLRRITSVQPGALSYEELVKEGTFGRIYAG---KLGESCE--ALVKTVIDGA 415
            :|......||.|:.|.||  .:...|...:::..|.||.::.|   ..|||.:  ..:| ||:..
  Rat   684 SIEPLDPSEKANKVLARI--FKETELRKLKVLGSGVFGTVHKGIWIPEGESIKIPVCIK-VIEDK 745

  Fly   416 SLTQVACLLQDASLLIG-VSHQHI--LAPLLANTELPGPPEIAYPHPSKGNLKMYLQKSRESSTA 477
            |..|....:.|..|.:| :.|.||  |..|...:.|    ::...:...|:|..::::.||:
  Rat   746 SGRQSFQAVTDHMLAVGSLDHAHIVRLLGLCPGSSL----QLVTQYLPLGSLLDHVKQHRET--- 803

  Fly   478 LSTRQLVEFGLHITKGLAYLHSLGIVHKDIATRNCYLDEESYVKICDSALSRDLFPDDYDCLGDN 542
            |..:.|:.:|:.|.||:.||....:||:|:|.||..|...|.|::.|..::..|.|||...|...
  Rat   804 LGPQLLLNWGVQIAKGMYYLEEHSMVHRDLALRNVMLKSPSQVQVADFGVADLLPPDDKQLLHSE 868

  Fly   543 ENRPLKWLSLESLQKRVYATQGDVWALGVTYWELVTLAQMPHEEVDIFELTNYLAAGFRLEQPVN 607
            ...|:||::|||:....|..|.|||:.|||.|||:|....|:..:.:.|:.:.|..|.||.||..
  Rat   869 AKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEIPDLLEKGERLAQPQI 933

  Fly   608 CPDEFFTVMNCCWHCEAKQRPTPSQLLSYLQDFHADLGMYI 648
            |..:.:.||..||..:...|||..:|.:.......|...|:
  Rat   934 CTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRYL 974

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drl-2	NP_001286371.1	WIF	37..156	CDD:280237	21/122 (17%)
		PTK_Ryk	373..644	CDD:270639	85/278 (31%)
		STYKc	389..637	CDD:214568	83/255 (33%)
Erbb3	NP_058914.2	Recep_L_domain	56..167	CDD:279382
		Furin-like	179..329	CDD:279142
		FU	183..215	CDD:214589
		FU	226..266	CDD:238021
		Recep_L_domain	353..474	CDD:279382	21/117 (18%)
		GF_recep_IV	499..630	CDD:291509	30/189 (16%)
		FU	500..553	CDD:238021	11/75 (15%)
		FU	548..592	CDD:214589	10/56 (18%)
		TM_ErbB3	638..674	CDD:213056	3/35 (9%)
		PKc_like	699..977	CDD:304357	88/286 (31%)
		Pkinase_Tyr	707..963	CDD:285015	84/263 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1023..1052
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1078..1215
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900