DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Drl-2 and Fras1

DIOPT Version :9

Sequence 1:	NP_001286371.1	Gene:	Drl-2 / 36436	FlyBaseID:	FBgn0033791	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	XP_038947596.1	Gene:	Fras1 / 289486	RGDID:	1306516	Length:	4014	Species:	Rattus norvegicus

Alignment Length:	730	Identity:	138/730 - (18%)
Similarity:	235/730 - (32%)	Gaps:	252/730 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 GYLNIFISHHEVM---KLMGLEA-----------DLFYVHEG---AINTYAMHF-----TVPVPA 67
            ||.::.||..:..   :|:.::|           ::.::.:|   ||.|..:..     ...|..
  Rat  1189 GYFSLKISDQQFFSEPQLINIQAFSTQAPYVLRNEVLHISKGERAAITTQLLDIRDDDNPQDVVL 1253

  Fly    68 DVHELEFSWQSLIAYPLPYAISIEYNNDQEALGTPTLSIPHKGLVPQEIESFLVYLPCTGNASLQ 132
            :|.:.....|.|...|.|.|...:::.|:.:.|  .|...|.|   .:..|.::........|.|
  Rat  1254 NVLDPPRHGQLLRTPPAPAASVYQFHVDELSRG--LLLYAHDG---SDSTSDIIVFQANDGHSFQ 1313

  Fly   133 MPVNVNMVVRAPPRFNDTRLHFKRNKIC------------------AKGISPE------PNQSP- 172
               |:...|:..|: ||..|....|.:.                  |.|:..:      .:..|
  Rat  1314 ---NILFRVKNVPK-NDRALRLVTNSMVWVPEGGMLKITNRILRAQAPGVRADDIIYKITHDHPQ 1374

  Fly   173 ---------APAHAPSQGPALLSAAACALGLVLAVGLVASMMYVRARKQLRQDSL----HTSFTT 224
                     .||.:|: |||       ..|..|..|.:.:.:...:::.: .|.:    |:..|.
  Rat  1375 FGEVVLLMNLPADSPA-GPA-------EEGHHLPDGRMTTPVSTFSQQDI-DDGIVWYRHSGATA 1430

  Fly   225 AAYGSHQNVFIRLDPLGRPPSATGSYATIASLNKYPADSKKSCSIFDRFRSSPTPTPYATALLPM 289
            .:...|..|               |.||.|                   :..|....:..|:||.
  Rat  1431 QSDSFHFQV---------------STATNA-------------------QEHPQSHMFNIAILPQ 1461

  Fly   290 NLEQTAETIYSKPESICPSRISYYASSQLT---QPCSLSTPKSIRSNGNGNCTSGSGSLSLFGGI 351
            .||              ..::|...|..:|   ...|:..|:|:   ..|...|.||.:.....:
  Rat  1462 ALE--------------APKLSLGTSLHMTAREDGLSVIHPQSL---SFGKAESPSGKIIYNITV 1509

  Fly   352 PTGSTITMASHGEKGNQRLRRIT--SVQPGALSYE------ELVKEGTFGRIYAGKLGESCEALV 408
            |......:..|..:.|..:|..|  .:..|.:.|.      .|.:...|.  :|| |.||.. ..
  Rat  1510 PLHPNQGVIEHRGRPNSPIRYFTQEEINQGQIMYRPPAAPPHLQEFMAFS--FAG-LPESVR-FY 1570

  Fly   409 KTVIDGASLTQVACLLQDASLLIGVSHQ-------HILAPLLANTELPG---------------- 450
            .||.||...:      .:.:|.|.:.|.       .|.||||..:  ||
  Rat  1571 FTVSDGQHTS------PEMALTIHLLHSDRQPPAFQIKAPLLEVS--PGGRTPLGLQLVVRDAEV 1627

  Fly   451 -PPEIAY---PHPSKGNLKMYLQKSRESSTALST-------RQLVEF------------------ 486
             |.|:.:   ..|..|.|..|..||..:.:|..|       |.::::
  Rat  1628 VPEELFFQLQKPPQHGMLMKYTAKSSVTMSAGDTFTYDEVERNVLQYVHDGSPAWEDNMEISVTD 1692

  Fly   487 GLHITKG---------------LAYLHSLGIV----HKDIATRN--CYLDEES-----YVKICD- 524
            ||.:|..               ||...||.:.    |..|.||:  .|:|:.|     ::::..
  Rat  1693 GLTVTTSEVKVEVSPSENREPRLAPGSSLSMTVASQHTAIITRSHLAYVDDSSPDSEIWIQLSSL 1757

  Fly   525 ---SALSRDLFPDDYDCLGDNENRPLKWLSLESLQKR------VYATQGDVWALGVTYWELVTLA 580
               ..|.:...||..:..||:.      .::|.:..:      |:.|:|.    .||.....:::
  Rat  1758 PLYGVLLKTSGPDMEELSGDSN------FTMEDINSKNIRYSAVFETEGQ----SVTDGFHFSVS 1812

  Fly   581 QMPHEEVD--IFELT 593
            .|.:..||  :|.:|
  Rat  1813 DMDNNRVDNQVFTIT 1827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drl-2	NP_001286371.1	WIF	37..156	CDD:280237	27/140 (19%)
		PTK_Ryk	373..644	CDD:270639	65/319 (20%)
		STYKc	389..637	CDD:214568	61/295 (21%)
Fras1	XP_038947596.1	VWC	27..86	CDD:214564
		VWC	94..151	CDD:278520
		VWC	158..>198	CDD:327433
		VWC	224..277	CDD:278520
		VWC	284..341	CDD:214564
		VWC	368..415	CDD:327433
		VSP	405..780	CDD:146106
		VSP	728..1059	CDD:146106
		FU	1045..1086	CDD:214589
		Cadherin_3	1101..1197	CDD:406568	3/7 (43%)
		Cadherin_3	1202..1309	CDD:406568	19/111 (17%)
		Cadherin_3	1313..1440	CDD:406568	25/154 (16%)
		Cadherin_3	1448..1576	CDD:406568	32/148 (22%)
		Cadherin_3	1579..1693	CDD:406568	21/121 (17%)
		Cadherin_3	1703..1813	CDD:406568	22/119 (18%)
		Cadherin_3	1822..1940	CDD:406568	2/6 (33%)
		Cadherin_3	1943..2061	CDD:406568
		Cadherin_3	2081..2181	CDD:406568
		Cadherin_3	2188..2295	CDD:406568
		Cadherin_3	2297..2408	CDD:406568
		Cadherin_3	2427..2539	CDD:406568
		Calx-beta	2555..2652	CDD:413355
		Calx-beta	2677..2763	CDD:413355
		caca	<2782..>3049	CDD:273296
		Calx-beta	3041..3135	CDD:413355
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900