DRSC/TRiP Functional Genomics Resources

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Protein Alignment Drl-2 and Erbb2

DIOPT Version :9

Sequence 1:NP_001286371.1 Gene:Drl-2 / 36436 FlyBaseID:FBgn0033791 Length:648 Species:Drosophila melanogaster
Sequence 2:NP_058699.2 Gene:Erbb2 / 24337 RGDID:2561 Length:1259 Species:Rattus norvegicus


Alignment Length:651 Identity:146/651 - (22%)
Similarity:233/651 - (35%) Gaps:193/651 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 MKLMGLEADLFYVHEGAINTYAMHFTVPVPADVHELEFSWQSLIAYPLPYAISIEYNNDQEALGT 101
            :.|:...|.|.:||           |||           |..|            :.|..:||  
  Rat   469 LALIHRNAHLCFVH-----------TVP-----------WDQL------------FRNPHQAL-- 497

  Fly   102 PTLSIPHKGLVPQE--------IESFLVYLPCTGNASLQMPVNVNMVVRAPPRFNDTRLHFKRNK 158
                 .|.|..|:|        ..|...:..|.|....|. ||.:              ||.|.:
  Rat   498 -----LHSGNRPEEDCGLEGLVCNSLCAHGHCWGPGPTQC-VNCS--------------HFLRGQ 542

  Fly   159 ICA------KGISPE--PNQSPAPAHAPSQ---------GPALLSAAACALGLVLAVGLVASMMY 206
            .|.      ||:..|  .::...|.|...|         |......||||               
  Rat   543 ECVEECRVWKGLPREYVSDKRCLPCHPECQPQNSSETCFGSEADQCAACA--------------- 592

  Fly   207 VRARKQLRQDSLHTSFTTAAYGSHQNVFIRLDPLGRPPSATGSYATIASLNKYPADS-------- 263
                        |...:::.             :.|.||......:...:.|||.:.        
  Rat   593 ------------HYKDSSSC-------------VARCPSGVKPDLSYMPIWKYPDEEGICQPCPI 632

  Fly   264 --KKSCSIFD------RFRSSPTPTPYAT---ALLPMNLEQTAETIYSKPESICPSRISYYASSQ 317
              ..||...|      ..|:||.....||   .||.:.|......:..:..    .:|..|...:
  Rat   633 NCTHSCVDLDERGCPAEQRASPVTFIIATVVGVLLFLILVVVVGILIKRRR----QKIRKYTMRR 693

  Fly   318 LTQPCSLSTPKSIRSNGNGNCTSGSGSLSLFGGIPTGSTITMASHGEKGNQRLRRITSVQPGALS 382
            |.|...|..|                 |:..|.:|..:.:.:....|     ||::         
  Rat   694 LLQETELVEP-----------------LTPSGAMPNQAQMRILKETE-----LRKV--------- 727

  Fly   383 YEELVKEGTFGRIYAG---KLGESCE--ALVKTVIDGASLTQVACLLQDASLLIGVSHQHI---L 439
              :::..|.||.:|.|   ..||:.:  ..:|.:.:..|......:|.:|.::.||...::   |
  Rat   728 --KVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLL 790

  Fly   440 APLLANTELPGPPEIAYPHPSKGNLKMYLQKSRESSTALSTRQLVEFGLHITKGLAYLHSLGIVH 504
            ...|.:|.......:.|     |.|   |...||....|.::.|:.:.:.|.||::||..:.:||
  Rat   791 GICLTSTVQLVTQLMPY-----GCL---LDHVREHRGRLGSQDLLNWCVQIAKGMSYLEDVRLVH 847

  Fly   505 KDIATRNCYLDEESYVKICDSALSRDLFPDDYDCLGDNENRPLKWLSLESLQKRVYATQGDVWAL 569
            :|:|.||..:...::|||.|..|:|.|..|:.:...|....|:||::|||:.:|.:..|.|||:.
  Rat   848 RDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSY 912

  Fly   570 GVTYWELVTLAQMPHEEVDIFELTNYLAAGFRLEQPVNCPDEFFTVMNCCWHCEAKQRPTPSQLL 634
            |||.|||:|....|::.:...|:.:.|..|.||.||..|..:.:.:|..||..:::.||...:|:
  Rat   913 GVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELV 977

  Fly   635 S 635
            |
  Rat   978 S 978

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Drl-2NP_001286371.1 WIF 37..156 CDD:280237 25/126 (20%)
PTK_Ryk 373..644 CDD:270639 78/271 (29%)
STYKc 389..637 CDD:214568 78/255 (31%)
Erbb2NP_058699.2 Recep_L_domain 55..177 CDD:279382
Furin-like 193..342 CDD:279142
FU 239..284 CDD:238021
Recep_L_domain 370..490 CDD:279382 10/54 (19%)
GF_recep_IV 514..647 CDD:291509 31/187 (17%)
FU 515..565 CDD:238021 13/64 (20%)
FU 561..607 CDD:214589 11/85 (13%)
TM_ErbB2 645..688 CDD:213055 9/46 (20%)
PTKc_HER2 716..994 CDD:270684 81/287 (28%)
Pkinase_Tyr 724..980 CDD:285015 80/274 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1025
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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