DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Drl-2 and Fras1

DIOPT Version :9

Sequence 1:	NP_001286371.1	Gene:	Drl-2 / 36436	FlyBaseID:	FBgn0033791	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_780682.3	Gene:	Fras1 / 231470	MGIID:	2385368	Length:	4010	Species:	Mus musculus

Alignment Length:	441	Identity:	94/441 - (21%)
Similarity:	146/441 - (33%)	Gaps:	164/441 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   271 DRFR---SSPTPTP-------YATALLPMNLEQTAETIYSKPESICPSRISYYASSQLT------ 319
            |.||   ||.|...       :..|:||           ..||:   .::|...|..:|
Mouse  1433 DSFRFQVSSATSAQEHLESHMFNIAILP-----------QAPEA---PKLSLGTSLHMTAREDGL 1483

  Fly   320 ---QPCSLSTPKSIRSNGNGNCTSGSGSLSLFGGIPTGSTITMASHGEKGNQRLRRIT--SVQPG 379
               ||.|||..|:         .|.||.:.....:|......:..|.::.:..::..|  .:..|
Mouse  1484 SVIQPQSLSFVKA---------ESPSGKIIYNITVPLHPNQGIIEHRDRPHSPIQYFTQEDINQG 1539

  Fly   380 ALSYEELVKEGTFGRI----YAGKLGESCEALVK---TVIDGASLTQVACLLQDASLLIGVSHQ- 436
            .:.|...|.......|    :|| |.||    ||   ||.||...:      .:.:|.|.:.|.
Mouse  1540 QIMYRPPVAPPHLQEIMAFSFAG-LPES----VKFYFTVSDGQHTS------PEMALTIHLLHSD 1593

  Fly   437 ------HILAPLLANTELPG-----------------PPEIAY---PHPSKGNLKMYLQKSRESS 475
                  .:.||||..:  ||                 |.|:.:   ..|..|.|..|..||..:.
Mouse  1594 LQPPAFQVKAPLLEVS--PGGRTSLGLQLLVRDAQVVPEELFFQLQKSPQHGMLVKYTAKSSVTM 1656

  Fly   476 TALST-------RQLVEF------------------GLHITKG---------------LAYLHSL 500
            .|..|       |.::::                  ||.:|..               ||...||
Mouse  1657 AAGDTFTYDEVERNVLQYVHDGSSAWEDSLEISVTDGLTVTTSEVKVEVSPSENRGPRLAPGSSL 1721

  Fly   501 GIV----HKDIATRN--CYLDEES-----YVKICDSALSRDLF----PDDYDCLGDNENRPLKWL 550
            .:.    |..|.||:  .|:|:.|     ::::....|...||    ||..:..||:.      .
Mouse  1722 SMTVASQHTAIITRSHLAYVDDSSSDPEIWIRLSSLPLYGVLFRSSGPDMDELSGDSN------F 1780

  Fly   551 SLESLQKR------VYATQGDVWALGVTYWELVTLAQMPHEEVD--IFELT 593
            ::|.:.|:      |:.|.|.    .||.....:::.|....||  :|.:|
Mouse  1781 TMEDINKKNIRYSAVFETDGH----SVTDGFHFSVSDMDGNHVDNQVFTIT 1827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drl-2	NP_001286371.1	WIF	37..156	CDD:280237
		PTK_Ryk	373..644	CDD:270639	69/320 (22%)
		STYKc	389..637	CDD:214568	65/302 (22%)
Fras1	NP_780682.3	VWC	27..86	CDD:214564
		VWC	94..151	CDD:278520
		VWC	158..215	CDD:278520
		VWC	220..277	CDD:278520
		VWC	284..341	CDD:302663
		VWC	368..415	CDD:302663
		FU 1	408..459
		GF_recep_IV	411..527	CDD:291509
		FU	420..>458	CDD:238021
		FU 2	461..504
		FU	461..503	CDD:214589
		FU 3	506..552
		FU	507..551	CDD:214589
		GF_recep_IV	511..623	CDD:291509
		FU 4	554..598
		FU	555..597	CDD:214589
		FU 5	601..646
		GF_recep_IV	606..728	CDD:291509
		FU	607..652	CDD:238021
		FU 6	648..704
		FU	649..703	CDD:214589
		FU 7	707..752
		FU	707..751	CDD:214589
		FU 8	754..799
		FU	754..798	CDD:214589
		Furin-like	759..912	CDD:279142
		FU 9	802..851
		FU	803..850	CDD:214589
		FU 10	853..899
		FU	853..898	CDD:214589
		FU 11	902..947
		Furin-like	905..1055	CDD:279142
		FU 12	951..996
		FU	951..995	CDD:214589
		FU 13	998..1041
		FU	1004..1048	CDD:238021
		Furin-like_2	1008..1098	CDD:292535
		FU 14	1045..1088
		FU	1045..1086	CDD:214589
		Cadherin_3	<1101..1197	CDD:292802
		CSPG 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1101..1196
		Cadherin_3	1167..1309	CDD:292802
		CSPG 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1216..1307
		Cadherin_3	1278..1440	CDD:292802	3/6 (50%)
		CSPG 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1328..1440		3/6 (50%)
		Cadherin_3	1411..1576	CDD:292802	39/170 (23%)
		CSPG 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1465..1561		19/107 (18%)
		Cadherin_3	1531..1693	CDD:292802	36/174 (21%)
		CSPG 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1597..1691		17/95 (18%)
		Cadherin_3	1662..1813	CDD:292802	29/160 (18%)
		CSPG 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1712..1812		25/109 (23%)
		Cadherin_3	1780..1940	CDD:292802	12/52 (23%)
		CSPG 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1834..1938
		Cadherin_3	1906..2061	CDD:292802
		CSPG 8. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1959..2059
		Cadherin_3	2030..2181	CDD:292802
		CSPG 9. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	2080..2179
		Cadherin_3	2149..2295	CDD:292802
		CSPG 10. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	2201..2293
		Cadherin_3	2263..2408	CDD:292802
		CSPG 11. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	2313..2406
		Cadherin_3	2377..2539	CDD:292802
		CSPG 12. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	2441..2538
		Calx-beta	2555..2648	CDD:295344
Calx-beta	2673..2759	CDD:295344
Calx-beta	2796..2892	CDD:295344
Calx-beta	2918..3009	CDD:295344
Calx-beta	3037..3131	CDD:295344
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900