DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Drl-2 and ERBB4

DIOPT Version :9

Sequence 1:	NP_001286371.1	Gene:	Drl-2 / 36436	FlyBaseID:	FBgn0033791	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	XP_016859066.1	Gene:	ERBB4 / 2066	HGNCID:	3432	Length:	1349	Species:	Homo sapiens

Alignment Length:	303	Identity:	84/303 - (27%)
Similarity:	144/303 - (47%)	Gaps:	36/303 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   363 GEKGNQRLRRITSVQPGALSYEELVKEGTFGRIYAG---------KLGESCEALVKTVIDGASLT 418
            |...||...||  ::...|...:::..|.||.:|.|         |:..:.:.|.:|....|::.
Human   743 GTAPNQAQLRI--LKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVE 805

  Fly   419 QVACLLQDASLLIGVSHQHI-------LAPLL-ANTELPGPPEIAYPHPSKGNLKMYLQKSRESS 475
                .:.:|.::..:.|.|:       |:|.: ..|:|       .||   |.|..|:.:.:::
Human   806 ----FMDEALIMASMDHPHLVRLLGVCLSPTIQLVTQL-------MPH---GCLLEYVHEHKDN- 855

  Fly   476 TALSTRQLVEFGLHITKGLAYLHSLGIVHKDIATRNCYLDEESYVKICDSALSRDLFPDDYDCLG 540
              :.::.|:.:.:.|.||:.||....:||:|:|.||..:...::|||.|..|:|.|..|:.:...
Human   856 --IGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNA 918

  Fly   541 DNENRPLKWLSLESLQKRVYATQGDVWALGVTYWELVTLAQMPHEEVDIFELTNYLAAGFRLEQP 605
            |....|:||::||.:..|.:..|.|||:.|||.|||:|....|::.:...|:.:.|..|.||.||
Human   919 DGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQP 983

  Fly   606 VNCPDEFFTVMNCCWHCEAKQRPTPSQLLSYLQDFHADLGMYI 648
            ..|..:.:.||..||..:|..||...:|.:.......|...|:
Human   984 PICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYL 1026

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drl-2	NP_001286371.1	WIF	37..156	CDD:280237
		PTK_Ryk	373..644	CDD:270639	78/287 (27%)
		STYKc	389..637	CDD:214568	76/264 (29%)
ERBB4	XP_016859066.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900