DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Drl-2 and ERBB2

DIOPT Version :9

Sequence 1:	NP_001286371.1	Gene:	Drl-2 / 36436	FlyBaseID:	FBgn0033791	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	XP_024306409.1	Gene:	ERBB2 / 2064	HGNCID:	3430	Length:	1301	Species:	Homo sapiens

Alignment Length:	627	Identity:	143/627 - (22%)
Similarity:	237/627 - (37%)	Gaps:	124/627 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 ISHHEVMKLMGLEADLFYVHEGAINTYA--MHFTVPVPADVHELEFSWQSLIAYPLPYAISIEYN 93
            ||...:..|..|.:.|..:|.   ||:.  :| |||           |..|...|....:.....
Human   496 ISWLGLRSLRELGSGLALIHH---NTHLCFVH-TVP-----------WDQLFRNPHQALLHTANR 545

  Fly    94 NDQEALGTPTLSIPHKGLVPQEIESFLVYLPCTGNASLQMPVNVNMVVRAPPRFNDTRL--HFKR 156
            .:.|.:|        :||...::   .....|.|....|. ||.:..:|......:.|:  ...|
Human   546 PEDECVG--------EGLACHQL---CARGHCWGPGPTQC-VNCSQFLRGQECVEECRVLQGLPR 598

  Fly   157 NKICAKGISP-EPNQSPAPAHAPSQGPALLSAAACALGLVLAVGLVASMMYVRARKQLRQDSLH- 219
            ..:.|:...| .|...|........||......|||                           |
Human   599 EYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACA---------------------------HY 636

  Fly   220 --TSFTTAAYGSHQNVFIRLDPLGRPPSATGSYATIASLNKYPADSKKSCSIFD------RFRSS 276
              ..|..|...|.....:...|:.:.|...|      :....|.:...||...|      ..|:|
Human   637 KDPPFCVARCPSGVKPDLSYMPIWKFPDEEG------ACQPCPINCTHSCVDLDDKGCPAEQRAS 695

  Fly   277 PTPTPYATALLPMNLEQTAETIYSKPESICPSRISYYASSQLTQPCSLSTPKSIRSNGNGNCTSG 341
            |. |...:|::.:.|......::.........:|..|...:|.|...|..|
Human   696 PL-TSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEP-------------- 745

  Fly   342 SGSLSLFGGIPTGSTITMASHGEKGNQRLRRITSVQPGALSYEELVKEGTFGRIYAG---KLGES 403
               |:..|.:|..:.:.:....|     ||::           :::..|.||.:|.|   ..||:
Human   746 ---LTPSGAMPNQAQMRILKETE-----LRKV-----------KVLGSGAFGTVYKGIWIPDGEN 791

  Fly   404 CE--ALVKTVIDGASLTQVACLLQDASLLIGVSHQHI---LAPLLANTELPGPPEIAYPHPSKGN 463
            .:  ..:|.:.:..|......:|.:|.::.||...::   |...|.:|.......:.|     |.
Human   792 VKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPY-----GC 851

  Fly   464 LKMYLQKSRESSTALSTRQLVEFGLHITKGLAYLHSLGIVHKDIATRNCYLDEESYVKICDSALS 528
            |   |...||:...|.::.|:.:.:.|.||::||..:.:||:|:|.||..:...::|||.|..|:
Human   852 L---LDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLA 913

  Fly   529 RDLFPDDYDCLGDNENRPLKWLSLESLQKRVYATQGDVWALGVTYWELVTLAQMPHEEVDIFELT 593
            |.|..|:.:...|....|:||::|||:.:|.:..|.|||:.|||.|||:|....|::.:...|:.
Human   914 RLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIP 978

  Fly   594 NYLAAGFRLEQPVNCPDEFFTVMNCCWHCEAKQRPTPSQLLS 635
            :.|..|.||.||..|..:.:.:|..||..:::.||...:|:|
Human   979 DLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVS 1020

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drl-2	NP_001286371.1	WIF	37..156	CDD:280237	24/122 (20%)
		PTK_Ryk	373..644	CDD:270639	78/271 (29%)
		STYKc	389..637	CDD:214568	78/255 (31%)
ERBB2	XP_024306409.1	Recep_L_domain	52..173	CDD:307256
		Furin-like	189..384	CDD:307072
		Recep_L_domain	412..532	CDD:307256	13/50 (26%)
		GF_recep_IV	557..689	CDD:317276	28/168 (17%)
		TM_ErbB2	687..730	CDD:213055	7/43 (16%)
		PTKc_HER2	758..1036	CDD:270684	81/287 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900