Protein Alignment Drl-2 and Ryk

DIOPT Version :10

• Sequence 1: NP_610835.2
• Gene: Drl-2 / 36436
• FlyBaseID: FBgn0033791
• Length: 648
• Species: Drosophila melanogaster
• Sequence 2: NP_038677.3
• Gene: Ryk / 20187
• MGIID: 101766
• Length: 594
• Species: Mus musculus
• Alignment Length: 694
• Identity: 209/694 - (30%)
• Similarity: 341/694 - (49%)
• Gaps: 164/694 - (23%)

  Fly     6 LKSPLPILLLCL------------TISTSVSG-YLNIFISHHEVMKLMGLEADLFYVHEGAINTY 57
            |::|.|.|||.|            .::.:.:| .:::::|..||.:|:||:|:|:||....|:.|
Mouse    14 LRAPPPPLLLLLLAMLPAAAPRSPALAAAPAGPSVSLYLSEDEVRRLLGLDAELYYVRNDLISHY 78

  Fly    58 AMHFTVPVPADVHELEFSW--QSLIAYPLPYAISIEYNNDQEALGTPTLSIPHKGLVPQEIESFL 120
            |:.|.:.||::.:.|.|:|  :|.:.|.|.:.:     ::..|:|.|.::|..:|.||:.:..|.
Mouse    79 ALSFNLLVPSETNFLHFTWHAKSKVEYKLGFQV-----DNFVAMGMPQVNISAQGEVPRTLSVFR 138

  Fly   121 VYLPCTG--NASLQMPVNVNMVVRAPPRFNDTRLHFKRNKICAKGISP------EPNQSPA---P 174
            |.|.|||  ::.:.:.:.:|:.|.:...|  |.|:|||.|:|.|.:..      :.|.|..   |
Mouse   139 VELSCTGKVDSEVMILMQLNLTVNSSKNF--TVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDP 201

  Fly   175 AH-APSQGPAL--LSAAACALGLVLAVGLVASMMYVRARKQLRQDSLHTSFTTAAYGSHQNVFIR 236
            .| ||:....:  :|...|. .::..|.::.:::::.:.|::..|
Mouse   202 VHAAPTTSTRVFYISVGVCC-AVIFLVAIILAVLHLHSMKRIELD-------------------- 245

  Fly   237 LDPLGRPPSATGSYATIASLNKYPADSKKSCSIFDRFRSSPTPTPYATALLPMNLEQTAETIYSK 301
                                     ||
Mouse   246 -------------------------DS-------------------------------------- 247

  Fly   302 PESICPSRISYYASSQ-LTQPCSLSTPKSIRSNGNGNCTSGSGSLSLFGGIPTGSTITMASHGEK 365
                    ||..:||| |:|| |..|.:.:|::...|.|..:.|    .|.||       ...||
Mouse   248 --------ISASSSSQGLSQP-STQTTQYLRADTPNNATPITSS----SGYPT-------LRIEK 292

  Fly   366 GNQRLRRITSVQPGA-----------LSYEELVKEGTFGRIYAGKL------GESCEALVKTVID 413
            .:  ||.:|.::..|           ::.:::::|||||||:.|.|      .:..:..||||.|
Mouse   293 ND--LRSVTLLEAKAKVKDIAISRERITLKDVLQEGTFGRIFHGILVDEKDPNKEKQTFVKTVKD 355

  Fly   414 GASLTQVACLLQDASLLIGVSHQHILAPLLANTELPGPPEIAYPHPSKGNLKMYLQKSR----ES 474
            .||..||..:|.::..|.|:.|:::|.......|....|.:..|:.:.||||::|::.:    .:
Mouse   356 QASEVQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVVLPYMNWGNLKLFLRQCKLVEANN 420

  Fly   475 STALSTRQLVEFGLHITKGLAYLHSLGIVHKDIATRNCYLDEESYVKICDSALSRDLFPDDYDCL 539
            ..|:|.:.||...:.|..|::||....::|:|:|.|||.:|:...|||.|:||||||||.||.||
Mouse   421 PQAISQQDLVHMAIQIACGMSYLARREVIHRDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCL 485

  Fly   540 GDNENRPLKWLSLESLQKRVYATQGDVWALGVTYWELVTLAQMPHEEVDIFELTNYLAAGFRLEQ 604
            |||||||::|::||||....:::..||||.|||.|||:||.|.|:.::|.||:..||..|:|:.|
Mouse   486 GDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQ 550

  Fly   605 PVNCPDEFFTVMNCCWHCEAKQRPTPSQLLSYLQDFHADLGMYI 648
            |:|||||.|.||.|||..:.::||...||:..|.:|||.||.|:
Mouse   551 PINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFHAALGAYV 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Drl-2	NP_610835.2	WIF	30..156	CDD:460414	41/129 (32%)
		PTK_Ryk	373..644	CDD:270639	118/291 (41%)
Ryk	NP_038677.3	WIF	47..180	CDD:128745	45/139 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	250..283		12/37 (32%)
		PTK_Ryk	310..590	CDD:270639	116/279 (42%)