Protein Alignment Drl-2 and lin-18

DIOPT Version :9

• Sequence 1: NP_001286371.1
• Gene: Drl-2 / 36436
• FlyBaseID: FBgn0033791
• Length: 648
• Species: Drosophila melanogaster
• Sequence 2: NP_508684.4
• Gene: lin-18 / 180679
• WormBaseID: WBGene00003007
• Length: 583
• Species: Caenorhabditis elegans
• Alignment Length: 670
• Identity: 194/670 - (28%)
• Similarity: 305/670 - (45%)
• Gaps: 137/670 - (20%)

  Fly    15 LCLTISTSVSGYLNIFISHHEVMKLMGLEADLFYVHEGAINTYAMHFTVPVPADVHELEFSWQSL 79
            |||       ..:|:|||..|:.:..|::|:|.|:..|.:::|:..|...|.|::..|.|:|.::
 Worm    15 LCL-------ANVNMFISKEEMNRTFGVKAELNYIEMGNVSSYSTKFHYRVMANIDYLSFTWNAV 72

  Fly    80 -IAYPLPYAISIEYNNDQEALGTPTLSIPHKGLVPQEIESFLVYLPCTGNASLQMPVNVNMVVRA 143
             |.:   |.:.:| ::|...|  |.:.||.||.||:.::.|.|...|.|:.|.|..|::....:.
 Worm    73 GIVH---YEVYVE-SDDSSVL--PIVRIPLKGTVPESLQDFTVEYRCAGHRSGQFAVSLYFTFKY 131

  Fly   144 PPRFNDTRLHFKRNKICAKGISPEPNQSPAPAHAPSQGPAL------LSAAACALGLVLAVGLVA 202
            ..: ...::..::.||||..............|......::      :...|.|..|::|..|:.
 Worm   132 GNK-EPLKVKLRQEKICASRDGRRGLNGGYEGHEVDDTDSIDKAFFVIICIAAAFLLIVAATLIC 195

  Fly   203 SMMYVRARKQLRQDSLHTSFTTAAYGSHQNV-----FIRLDPLGRPPSATGSYATIASLNKYPAD 262
               |.:..|  ::|.:.|...|:...|.::.     |:...|...||       |:::::..|..
 Worm   196 ---YFKRSK--KEDMIPTRLPTSFRNSLKSTKSAQPFLLSTPRDGPP-------TLSAISSAPCS 248

  Fly   263 SKKSCSIFDRFRSSPTPTPYATALLPMNLEQTAETIYSKPESICPSRISYYASSQLTQPCSLSTP 327
            |..:.               ..:::|           |||.:|...|    |..||.|
 Worm   249 SSSAS---------------GNSIIP-----------SKPRNIDVRR----ALLQLYQ------- 276

  Fly   328 KSIRSNGNGNCTSGSGSLSLFGGIPTGSTITMASHGEKGNQRL---RRITSVQPGALSYEELVKE 389
                            ....|..:|      :...|..|..|.   |::..|..|.:..|    |
 Worm   277 ----------------DRDAFQSLP------LDMEGTFGEVRYAIWRQVDDVLNGDVDDE----E 315

  Fly   390 GTFGRIYAGKLGESC--EAL-VKTVIDGASLTQVACLLQDASLLIGVS-HQHI--LAPLLANTEL 448
            .||           |  ||: .||:.:.||..|:...|.||.|...:: ||::  :|.:.:....
 Worm   316 DTF-----------CNQEAVYTKTLKNNASPIQLDRFLSDALLFYNITPHQNLSQVACVASFGRF 369

  Fly   449 PGP------PEIAYPHPSKGNLKMYL------QKSRESSTALSTRQLVEFGLHITKGLAYLHSLG 501
            ..|      |.:.|.|...||||.:|      .|::.:.| |.|.|||.....::..:|::|...
 Worm   370 DRPETVTDFPLVCYRHQGFGNLKKFLTICRHGDKTKGAQT-LRTHQLVSLATQVSSAVAHIHKYR 433

  Fly   502 IVHKDIATRNCYLDEES---YVKICDSALSRDLFPDDYDCLGDNENRPLKWLSLESLQKRVYATQ 563
            |||.|||.|||.:.|.:   .|::|||||||||||.||.||||||||||||:|.|::...:|::.
 Worm   434 IVHNDIAARNCLIAEVNGRLQVQLCDSALSRDLFPADYHCLGDNENRPLKWMSPEAIANELYSSA 498

  Fly   564 GDVWALGVTYWELVTLAQMPHEEVDIFELTNYLAAGFRLEQPVNCPDEFFTVMNCCWHCEAKQRP 628
            .|||:|||..|||::|...||.|:|..|:...:..|.||:||.||||:.:.||.|||...::.||
 Worm   499 ADVWSLGVLLWELMSLGGSPHAEIDPEEVYTMILKGKRLQQPNNCPDQLYEVMLCCWRVLSEDRP 563

  Fly   629 TPSQLLSYLQDFHADLGMYI 648
            :..|::..|:||:..|..||
 Worm   564 SSEQVVHGLRDFNIQLSQYI 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Drl-2	NP_001286371.1	WIF	37..156	CDD:280237	31/119 (26%)
		PTK_Ryk	373..644	CDD:270639	113/291 (39%)
		STYKc	389..637	CDD:214568	107/268 (40%)
lin-18	NP_508684.4	WIF	19..149	CDD:128745	39/136 (29%)
		PTK_Ryk	274..579	CDD:270639	121/349 (35%)
		Pkinase_Tyr	289..572	CDD:285015	114/298 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	187	1.000	Domainoid score	I1974
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H68287
Inparanoid	1	1.050	264	1.000	Inparanoid score	I1880
Isobase	1	0.950	-	0	Normalized mean entropy	S3376
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D359098at33208
OrthoFinder	1	1.000	-	-		FOG0005256
OrthoInspector	1	1.000	-	-		otm14716
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3316
SonicParanoid	1	1.000	-	-		X3777
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.850