DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Drl-2 and nipi-4

DIOPT Version :9

Sequence 1:	NP_001286371.1	Gene:	Drl-2 / 36436	FlyBaseID:	FBgn0033791	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_505028.3	Gene:	nipi-4 / 179167	WormBaseID:	WBGene00077712	Length:	396	Species:	Caenorhabditis elegans

Alignment Length:	337	Identity:	80/337 - (23%)
Similarity:	128/337 - (37%)	Gaps:	98/337 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   371 RRITSVQPGALSY---EELVKEGTF-------GRIYAG----KLGESCEALVKTV--IDGASLTQ 419
            :|:|.::....:|   ||.::...|       |.|:.|    |......|.|.|.  |....:::
Worm    61 KRLTQLERELKNYLIDEESIEVDDFQIGQTADGFIFRGGVFPKTRNRFNAKVTTAVKISFPIVSK 125

  Fly   420 VACLLQDASLLIGVSHQHIL-------------APLLANTELPGPPEIAYPHPSKGNLKMYLQ-K 470
            ...||:||..|..:.|.:::             .|::|...|||           |.|..|.| |
Worm   126 SISLLEDALRLSKLDHPNLIRLLAVSQLSFTVFRPMIALEWLPG-----------GTLADYFQFK 179

  Fly   471 SRESS----TALSTRQLVEFGLHITKGLAYLHS----LG--IVHKDIATRNCYLDEESYVKICDS 525
            .||..    :.:..:.::.....:::.|.|:||    .|  :.|..|.|||..:.|
Worm   180 VREKDDSERSPIQLKDMLSILYQVSQALKYIHSQLDEFGQELTHGRIFTRNVLVTE--------- 235

  Fly   526 ALSRDLFPDDYDC---LGDNENRP---------LKWLSLESL--QKRV--YATQGDVWALGVTYW 574
                   ||...|   |||..:.|         :.::..|.|  .:|:  :..:.|||..||..|
Worm   236 -------PDLRKCEVKLGDFGDAPMGLEYSTPIIAYMPPEILCCAERIPPHRPENDVWMFGVFIW 293

  Fly   575 ELVTLAQMPHEEVDIFELTNYLAAGFRLEQ-----PVNCPDEFFTVMNCCWHCEAKQRP-----T 629
            |.:||...||....:.|:..    .|||..     |..||.:.:|:::.|. .|...||     |
Worm   294 ECLTLGAQPHFRKSVEEIKK----SFRLPDRGLSCPPTCPLDVWTLVSDCL-SEPHMRPRFASTT 353

  Fly   630 PSQLLSYLQDFH 641
            .:.:.|.|.:.|
Worm   354 NASITSRLSELH 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drl-2	NP_001286371.1	WIF	37..156	CDD:280237
		PTK_Ryk	373..644	CDD:270639	79/335 (24%)
		STYKc	389..637	CDD:214568	73/310 (24%)
nipi-4	NP_505028.3	PKc_like	86..350	CDD:304357	70/295 (24%)
nipi-4	NP_505028.3	Pkinase_Tyr	87..350	CDD:285015	70/294 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900