Protein Alignment Drl-2 and Ryk

DIOPT Version :9

• Sequence 1: NP_001286371.1
• Gene: Drl-2 / 36436
• FlyBaseID: FBgn0033791
• Length: 648
• Species: Drosophila melanogaster
• Sequence 2: NP_536327.1
• Gene: Ryk / 140585
• RGDID: 620549
• Length: 594
• Species: Rattus norvegicus
• Alignment Length: 694
• Identity: 210/694 - (30%)
• Similarity: 341/694 - (49%)
• Gaps: 164/694 - (23%)

  Fly     6 LKSPLPILLLCL------------TISTSVSG-YLNIFISHHEVMKLMGLEADLFYVHEGAINTY 57
            |::|.|.|||.|            .::.:.:| .:::::|..||.:|:||:|:|:||....|:.|
  Rat    14 LRAPPPPLLLLLLAMLPAAAPRSPALAAAPAGPSVSLYLSEDEVRRLLGLDAELYYVRNDLISHY 78

  Fly    58 AMHFTVPVPADVHELEFSW--QSLIAYPLPYAISIEYNNDQEALGTPTLSIPHKGLVPQEIESFL 120
            |:.|.:.||::.:.|.|:|  :|.:.|.|.:.:     ::..|:|.|.::|..:|.||:.:..|.
  Rat    79 ALSFNLLVPSETNFLHFTWHAKSKVEYKLGFQV-----DNFVAMGMPQVNISAQGEVPRTLSVFR 138

  Fly   121 VYLPCTG--NASLQMPVNVNMVVRAPPRFNDTRLHFKRNKICAKGISP------EPNQSPA---P 174
            |.|.|||  ::.:.:.:.:|:.|.:...|  |.|:|||.|:|.|.:..      :.|.|..   |
  Rat   139 VELSCTGKVDSEVMILMQLNLTVNSSKNF--TVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDP 201

  Fly   175 AH-APSQGPAL--LSAAACALGLVLAVGLVASMMYVRARKQLRQDSLHTSFTTAAYGSHQNVFIR 236
            .| ||:....:  :|...|. .::..|.::.:::::.:.|::..|
  Rat   202 VHAAPTTSTRVFYISVGVCC-AVIFLVAIILAVLHLHSMKRIELD-------------------- 245

  Fly   237 LDPLGRPPSATGSYATIASLNKYPADSKKSCSIFDRFRSSPTPTPYATALLPMNLEQTAETIYSK 301
                                     ||
  Rat   246 -------------------------DS-------------------------------------- 247

  Fly   302 PESICPSRISYYASSQ-LTQPCSLSTPKSIRSNGNGNCTSGSGSLSLFGGIPTGSTITMASHGEK 365
                    ||..:||| |:|| |..|.:.:|::...|.|..:.|    .|.||       ...||
  Rat   248 --------ISASSSSQGLSQP-STQTTQYLRADTPNNATPVTSS----SGYPT-------LRIEK 292

  Fly   366 GNQRLRRITSVQPGA-----------LSYEELVKEGTFGRIYAGKL------GESCEALVKTVID 413
            .:  ||.:|.::..|           ::.:::::|||||||:.|.|      .:..:..||||.|
  Rat   293 ND--LRSVTLLEAKAKVKDIAISRERVTLKDVLQEGTFGRIFHGILVDEKDPNKEKQTFVKTVKD 355

  Fly   414 GASLTQVACLLQDASLLIGVSHQHILAPLLANTELPGPPEIAYPHPSKGNLKMYLQKSR----ES 474
            .||..||..:|.::..|.|:.|:::|.......|....|.:..|:.:.||||::|::.:    .:
  Rat   356 QASEVQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVISPYMNWGNLKLFLRQCKLVEANN 420

  Fly   475 STALSTRQLVEFGLHITKGLAYLHSLGIVHKDIATRNCYLDEESYVKICDSALSRDLFPDDYDCL 539
            ..|:|.:.||...:.|..|::||....::|||:|.|||.:|:...|||.|:||||||||.||.||
  Rat   421 PQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCL 485

  Fly   540 GDNENRPLKWLSLESLQKRVYATQGDVWALGVTYWELVTLAQMPHEEVDIFELTNYLAAGFRLEQ 604
            |||||||::|::||||....:::..||||.|||.|||:||.|.|:.::|.||:..||..|:|:.|
  Rat   486 GDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQ 550

  Fly   605 PVNCPDEFFTVMNCCWHCEAKQRPTPSQLLSYLQDFHADLGMYI 648
            |:|||||.|.||.|||..:.::||...||:..|.:|||.||.|:
  Rat   551 PINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFHAALGAYV 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Drl-2	NP_001286371.1	WIF	37..156	CDD:280237	38/122 (31%)
		PTK_Ryk	373..644	CDD:270639	119/291 (41%)
		STYKc	389..637	CDD:214568	113/257 (44%)
Ryk	NP_536327.1	WIF	47..180	CDD:128745	45/139 (32%)
		PTK_Ryk	310..590	CDD:270639	117/279 (42%)
		Pkinase_Tyr	317..583	CDD:285015	113/265 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	88	1.000	Domainoid score	I7749
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68287
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D359098at33208
OrthoFinder	1	1.000	-	-		FOG0005256
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3777
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.880