DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Drl-2 and Erbb3

DIOPT Version :9

Sequence 1:NP_001286371.1 Gene:Drl-2 / 36436 FlyBaseID:FBgn0033791 Length:648 Species:Drosophila melanogaster
Sequence 2:NP_034283.1 Gene:Erbb3 / 13867 MGIID:95411 Length:1339 Species:Mus musculus


Alignment Length:692 Identity:153/692 - (22%)
Similarity:255/692 - (36%) Gaps:171/692 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 LNIFISHHEVMKLMGLEADLFYVHEGAINTYAMHFTVPVPADVHELEFSWQSLIA----YPLPYA 87
            ||:|.:..|:...:.:::...::|         :|:|          ||..:.|.    |...::
Mouse   384 LNVFRTVREITGYLNIQSWPPHMH---------NFSV----------FSNLTTIGGRSLYNRGFS 429

  Fly    88 ISIEYNNDQEALGTPTLSIPHKGLVPQEIESFLVYLPCTGNASLQMPVNVNMVVRAPPRFNDTRL 152
            :.|..|.:..:||..:|         :||.:..||:...........:|...::|.|.   :.||
Mouse   430 LLIMKNLNVTSLGFRSL---------KEISAGRVYISANQQLCYHHSLNWTRLLRGPA---EERL 482

  Fly   153 HFKRNK----ICAKGISPEPNQSPAPAHAPSQGPALLSAAACALGLVLAVGLVASMMYVRARKQL 213
            ..|.|:    ..|:|...:|..|......|..|..|    :|                    :..
Mouse   483 DIKYNRPLGECVAEGKVCDPLCSSGGCWGPGPGQCL----SC--------------------RNY 523

  Fly   214 RQDSLHTSFTTAAYGS-----HQNVFIRLDPLGRPPSATGSYATIASLNKYPADSKKSCSIFDRF 273
            .::.:..:......|.     |:.......|..:|...|      ::.|...:|:...|:   .|
Mouse   524 SREGVCVTHCNVLQGEPREFVHEAHCFSCHPECQPMEGT------STCNGSGSDACARCA---HF 579

  Fly   274 RSSPTPTPYATALLPMNLEQTAETIYSKPESICPSRISYYASSQLTQPCSLSTPKSIRSNGNGNC 338
            |..    |:.....|..:......||..|:           :....:||            :.||
Mouse   580 RDG----PHCVNSCPHGILGAKGPIYKYPD-----------AQNECRPC------------HENC 617

  Fly   339 TSG-------------------------------------SGSLSLFGG------------IPTG 354
            |.|                                     .||...:.|            :..|
Mouse   618 TQGCKGPELQDCLGQAEVLMSKPHLVIAVTVGLTVIFLILGGSFLYWRGRRIQNKRAMRRYLERG 682

  Fly   355 STITMASHGEKGNQRLRRITSVQPGALSYEELVKEGTFGRIYAG---KLGESCE--ALVKTVIDG 414
            .:|......||.|:.|.||  .:...|...:::..|.||.::.|   ..|||.:  ..:| ||:.
Mouse   683 ESIEPLDPSEKANKVLARI--FKETELRKLKVLGSGVFGTVHKGIWIPEGESIKIPVCIK-VIED 744

  Fly   415 ASLTQVACLLQDASLLIG-VSHQHI--LAPLLANTELPGPPEIAYPHPSKGNLKMYLQKSRESST 476
            .|..|....:.|..|.:| :.|.||  |..|...:.|    ::...:...|:|..::::.||:  
Mouse   745 KSGRQSFQAVTDHMLAVGSLDHAHIVRLLGLCPGSSL----QLVTQYLPLGSLLDHVRQHRET-- 803

  Fly   477 ALSTRQLVEFGLHITKGLAYLHSLGIVHKDIATRNCYLDEESYVKICDSALSRDLFPDDYDCLGD 541
             |..:.|:.:|:.|.||:.||....:||:|:|.||..|...|.|::.|..::..|.|||...|..
Mouse   804 -LGPQLLLNWGVQIAKGMYYLEEHSMVHRDLALRNVMLKSPSQVQVADFGVADLLPPDDKQLLHS 867

  Fly   542 NENRPLKWLSLESLQKRVYATQGDVWALGVTYWELVTLAQMPHEEVDIFELTNYLAAGFRLEQPV 606
            ....|:||::|||:....|..|.|||:.|||.|||:|....|:..:.:.|:.:.|..|.||.||.
Mouse   868 EAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEIPDLLEKGERLAQPQ 932

  Fly   607 NCPDEFFTVMNCCWHCEAKQRPTPSQLLSYLQDFHADLGMYI 648
            .|..:.:.||..||..:...|||..:|.:.......|...|:
Mouse   933 ICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRYL 974

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Drl-2NP_001286371.1 WIF 37..156 CDD:280237 21/122 (17%)
PTK_Ryk 373..644 CDD:270639 85/278 (31%)
STYKc 389..637 CDD:214568 83/255 (33%)
Erbb3NP_034283.1 Recep_L_domain 56..167 CDD:279382
Furin-like 179..329 CDD:279142
FU 180..215 CDD:214589
FU 226..266 CDD:238021
Recep_L_domain 353..474 CDD:279382 21/117 (18%)
GF_recep_IV 499..630 CDD:291509 27/190 (14%)
FU 500..542 CDD:238021 7/65 (11%)
FU 548..592 CDD:214589 10/56 (18%)
TM_ErbB3 638..674 CDD:213056 3/35 (9%)
PKc_like 699..977 CDD:304357 88/286 (31%)
Pkinase_Tyr 707..963 CDD:285015 84/263 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1028..1052
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1077..1156
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1181..1212
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1025
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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