DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Drl-2 and Egfr

DIOPT Version :9

Sequence 1:NP_001286371.1 Gene:Drl-2 / 36436 FlyBaseID:FBgn0033791 Length:648 Species:Drosophila melanogaster
Sequence 2:NP_997538.1 Gene:Egfr / 13649 MGIID:95294 Length:1210 Species:Mus musculus


Alignment Length:447 Identity:108/447 - (24%)
Similarity:174/447 - (38%) Gaps:97/447 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   288 PMNLEQTAETIYSKPESI-------CPSR-------ISYYASSQLTQPCSLSTPKSIRSNGN--- 335
            |....:.:|.|...||.:       |..|       .::|...   ..|..:.|..|....|   
Mouse   546 PREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDG---PHCVKTCPAGIMGENNTLV 607

  Fly   336 --------------GNCTSGSGSLSLFG--GIPTGSTITMASHGEKG------------------ 366
                          .|||.|.....|.|  ..|:|..|...:.|..|                  
Mouse   608 WKYADANNVCHLCHANCTYGCAGPGLQGCEVWPSGPKIPSIATGIVGGLLFIVVVALGIGLFMRR 672

  Fly   367 -----NQRLRRITS----VQPGALSYE-------ELVKE-----------GTFGRIYAG---KLG 401
                 .:.|||:..    |:|...|.|       .::||           |.||.:|.|   ..|
Mouse   673 RHIVRKRTLRRLLQERELVEPLTPSGEAPNQAHLRILKETEFKKIKVLGSGAFGTVYKGLWIPEG 737

  Fly   402 ESCE--ALVKTVIDGASLTQVACLLQDASLLIGVSHQHI---LAPLLANTELPGPPEIAYPHPSK 461
            |..:  ..:|.:.:..|......:|.:|.::..|.:.|:   |...|.:|.......:.|     
Mouse   738 EKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPY----- 797

  Fly   462 GNLKMYLQKSRESSTALSTRQLVEFGLHITKGLAYLHSLGIVHKDIATRNCYLDEESYVKICDSA 526
            |.|..|:   ||....:.::.|:.:.:.|.||:.||....:||:|:|.||..:....:|||.|..
Mouse   798 GCLLDYV---REHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFG 859

  Fly   527 LSRDLFPDDYDCLGDNENRPLKWLSLESLQKRVYATQGDVWALGVTYWELVTLAQMPHEEVDIFE 591
            |::.|..::.:...:....|:||::|||:..|:|..|.|||:.|||.|||:|....|::.:...:
Mouse   860 LAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASD 924

  Fly   592 LTNYLAAGFRLEQPVNCPDEFFTVMNCCWHCEAKQRPTPSQLLSYLQDFHADLGMYI 648
            :::.|..|.||.||..|..:.:.:|..||..:|..||...:|:........|...|:
Mouse   925 ISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELILEFSKMARDPQRYL 981

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Drl-2NP_001286371.1 WIF 37..156 CDD:280237
PTK_Ryk 373..644 CDD:270639 80/300 (27%)
STYKc 389..637 CDD:214568 75/266 (28%)
EgfrNP_997538.1 Recep_L_domain 57..168 CDD:279382
Approximate 75..300
Furin-like 184..335 CDD:279142
FU 231..274 CDD:238021
Recep_L_domain 362..481 CDD:279382
Approximate 390..600 10/56 (18%)
GF_recep_IV 505..636 CDD:291509 17/92 (18%)
FU 506..559 CDD:238021 3/12 (25%)
FU 552..598 CDD:214589 9/48 (19%)
TM_ErbB1 634..679 CDD:213054 6/44 (14%)
Important for dimerization, phosphorylation and activation. /evidence=ECO:0000250 690..706 4/15 (27%)
PTKc_EGFR 706..1018 CDD:270683 78/284 (27%)
TyrKc 715..970 CDD:197581 74/262 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1113..1137
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1025
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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