DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Drl-2 and si:ch73-383l1.1

DIOPT Version :9

Sequence 1:	NP_001286371.1	Gene:	Drl-2 / 36436	FlyBaseID:	FBgn0033791	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	XP_021331611.1	Gene:	si:ch73-383l1.1 / 101885162	ZFINID:	ZDB-GENE-121214-64	Length:	1392	Species:	Danio rerio

Alignment Length:	425	Identity:	102/425 - (24%)
Similarity:	172/425 - (40%)	Gaps:	93/425 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   281 PYATALLPMNLEQTAETIYSKPESICPSRISYYASSQLTQPCSLSTPKSIRSNGNGNCTSG-SG- 343
            |......|..|:.....|:..||           ::....||            :.|||.| :|
Zfish   586 PNCVEKCPDGLQGANSFIFKYPE-----------TNNECHPC------------HPNCTQGCTGP 627

  Fly   344 ---------------SLSLFGG------IPTGSTITMASHGEKGNQRLRR------ITSVQPGAL 381
                           :..:.||      :..|..|.......|..:.|||      :..:.|...
Zfish   628 RIQDCIGILDRTPLIAAGVIGGMFVVVIVALGFAIFFRRKSIKKKRALRRFLETELVEPLTPSGT 692

  Fly   382 SYEE----LVKE-----------GTFGRIYAG---KLGESCEALVKTVIDGASLTQVACL--LQD 426
            :..:    ::||           |.||.:|.|   ..||:.:..|...|...|....|.:  :.:
Zfish   693 APNQAQLRILKETELKRVKILGTGAFGTVYKGIWVPEGETVKIPVAIKILNESTGPKANVEFMDE 757

  Fly   427 ASLLIGVSHQHI-------LAPLL-ANTELPGPPEIAYPHPSKGNLKMYLQKSRESSTALSTRQL 483
            |.::..:.|.|:       |:|.: ..|:|       .||   |.|..|:.:.:::   :.::.|
Zfish   758 ALIMASMEHPHLVRLLGVCLSPTIQLVTQL-------MPH---GCLLDYVHEHQDN---IGSQLL 809

  Fly   484 VEFGLHITKGLAYLHSLGIVHKDIATRNCYLDEESYVKICDSALSRDLFPDDYDCLGDNENRPLK 548
            :.:.:.|.||:.||....:||:|:|.||..:...:::||.|..|:|.|..::.:...|....|:|
Zfish   810 LNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLETNEKEYSADEGKMPIK 874

  Fly   549 WLSLESLQKRVYATQGDVWALGVTYWELVTLAQMPHEEVDIFELTNYLAAGFRLEQPVNCPDEFF 613
            |::||.:..|.:..|.|||:.|||.|||:|....|::.:...|:.:.|..|.||.||..|..:.:
Zfish   875 WMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDILEKGERLPQPPICTIDVY 939

  Fly   614 TVMNCCWHCEAKQRPTPSQLLSYLQDFHADLGMYI 648
            .||..||..:|..||...:|.:.......|...|:
Zfish   940 MVMVKCWMIDADSRPRFKELAAEFSRMARDPQRYL 974

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drl-2	NP_001286371.1	WIF	37..156	CDD:280237
		PTK_Ryk	373..644	CDD:270639	79/298 (27%)
		STYKc	389..637	CDD:214568	77/271 (28%)
si:ch73-383l1.1	XP_021331611.1	Recep_L_domain	54..166	CDD:307256
		Furin-like	183..331	CDD:307072
		Recep_L_domain	357..477	CDD:307256
		GF_recep_IV	501..633	CDD:317276	13/69 (19%)
		TM_ErbB4	631..674	CDD:213053	5/42 (12%)
		PKc_like	699..995	CDD:328722	80/289 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900