DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Su(z)2 and PCGF1

DIOPT Version :9

Sequence 1:	NP_001260933.1	Gene:	Su(z)2 / 36432	FlyBaseID:	FBgn0265623	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	NP_116062.2	Gene:	PCGF1 / 84759	HGNCID:	17615	Length:	259	Species:	Homo sapiens

Alignment Length:	256	Identity:	71/256 - (27%)
Similarity:	120/256 - (46%)	Gaps:	52/256 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 NTMESNAAMDAASPASRD------VRQFHDLITCRLCRGYMIDPTTVDYCYHTYCRSCILKHLLR 66
            |.::|...||   |...:      ::..::.|.|.||.||.:|.||:..|.||:|:|||:|:|..
Human    17 NQLQSVYKMD---PLRNEEEVRVKIKDLNEHIVCCLCAGYFVDATTITECLHTFCKSCIVKYLQT 78

  Fly    67 AVYCPECKASGGKEINE----LNLKSDDTLRSLIYKLVPGLYQRECKELADFKEQH--DLVDEQT 125
            :.|||.|..    :|:|    ||||.|..::.::|||||||...|.|.:.:|.:..  |.|.:.|
Human    79 SKYCPMCNI----KIHETQPLLNLKLDRVMQDIVYKLVPGLQDSEEKRIREFYQSRGLDRVTQPT 139

  Fly   126 TDEP-----------------EFFTTTELISLSLEYHPAMLHQCGPGE-----VPPTIYLQCAAG 168
            .:||                 .::...|.::|.||       :...|:     |....|::|:..
Human   140 GEEPALSNLGLPFSSFDHSKAHYYRYDEQLNLCLE-------RLSSGKDKNKSVLQNKYVRCSVR 197

  Fly   169 LPVELLKRFLCSKYNIETDNGLVEVEVTYKDEVLPTNFTLMDVAYCYNWSRESPMAFCYRI 229
            ..|..|:|.||.:..:...:    |::.:.:||||.:.|:..:.....:.:.||:...|.:
Human   198 AEVRHLRRVLCHRLMLNPQH----VQLLFDNEVLPDHMTMKQIWLSRWFGKPSPLLLQYSV 254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(z)2	NP_001260933.1	zf-C3HC4	35..73	CDD:278524	20/37 (54%)
Su(z)2	NP_001260933.1	RAWUL	143..228	CDD:292824	18/89 (20%)
PCGF1	NP_116062.2	RING-HC_PCGF1	44..86	CDD:319647	21/41 (51%)
		RING-HC finger (C3HC4-type)	47..85	CDD:319647	20/37 (54%)
		Required for repressor activity	86..247		41/175 (23%)
		Required for the interaction with the KDM2B-SKP1 heterodimeric complex. /evidence=ECO:0000269\|PubMed:27568929	150..255		22/116 (19%)
		RAWUL_PCGF1	166..253	CDD:340601	21/97 (22%)
		RING-finger and WD40-associated ubiquitin-like domain (RAWUL), sufficient for interaction with BCOR and BCORL1. /evidence=ECO:0000269\|PubMed:23523425, ECO:0000269\|PubMed:27568929	167..255		22/99 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157887
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2660
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1203951at2759
OrthoFinder	1	1.000	-	-		FOG0000290
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750