Protein Alignment Su(z)2 and Pcgf1

DIOPT Version :10

• Sequence 1: NP_001260933.1
• Gene: Su(z)2 / 36432
• FlyBaseID: FBgn0265623
• Length: 1396
• Species: Drosophila melanogaster
• Sequence 2: NP_932109.2
• Gene: Pcgf1 / 69837
• MGIID: 1917087
• Length: 259
• Species: Mus musculus
• Alignment Length: 256
• Identity: 71/256 - (27%)
• Similarity: 120/256 - (46%)
• Gaps: 52/256 - (20%)

  Fly     8 NTMESNAAMDAASPASRD------VRQFHDLITCRLCRGYMIDPTTVDYCYHTYCRSCILKHLLR 66
            |.::|...||   |...:      ::..::.|.|.||.||.:|.||:..|.||:|:|||:|:|..
Mouse    17 NQLQSVYKMD---PLRNEEEVRVKIKDLNEHIVCCLCAGYFVDATTITECLHTFCKSCIVKYLQT 78

  Fly    67 AVYCPECKASGGKEINE----LNLKSDDTLRSLIYKLVPGLYQRECKELADFKEQH--DLVDEQT 125
            :.|||.|..    :|:|    ||||.|..::.::|||||||...|.|.:.:|.:..  |.|.:.:
Mouse    79 SKYCPMCNI----KIHETQPLLNLKLDRVMQDIVYKLVPGLQDSEEKRIREFYQSRGLDRVSQPS 139

  Fly   126 TDEP-----------------EFFTTTELISLSLEYHPAMLHQCGPGE-----VPPTIYLQCAAG 168
            .:||                 .::...|.:||.||       :...|:     |....|::|:..
Mouse   140 GEEPALSNLGLPFSSFDHSKAHYYRYDEQLSLCLE-------RLSSGKDKNKNVLQNKYVRCSVR 197

  Fly   169 LPVELLKRFLCSKYNIETDNGLVEVEVTYKDEVLPTNFTLMDVAYCYNWSRESPMAFCYRI 229
            ..|..|:|.||.:..:...:    |::.:.:||||.:.|:..:.....:.:.||:...|.:
Mouse   198 AEVRHLRRVLCHRLMLNPQH----VQLLFDNEVLPDHMTMKQLWLSRWFGKPSPLLLQYSV 254

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(z)2	NP_001260933.1	RING-HC_PCGF5	23..117	CDD:438395	39/103 (38%)
		RAWUL_PCGF2_like	137..228	CDD:340602	21/95 (22%)
Pcgf1	NP_932109.2	RING-HC_PCGF1	36..106	CDD:438391	29/73 (40%)
		Necessary for repressor activity. /evidence=ECO:0000250	86..247		41/175 (23%)
		Required for the interaction with the KDM2B-SKP1 heterodimeric complex. /evidence=ECO:0000250|UniProtKB:Q9BSM1	150..255		23/116 (20%)
		RAWUL_PCGF1	166..253	CDD:340601	22/97 (23%)
		RING-finger and WD40-associated ubiquitin-like domain (RAWUL), sufficient for interaction with BCOR and BCORL1. /evidence=ECO:0000250|UniProtKB:Q9BSM1	167..255		23/99 (23%)