Protein Alignment Su(z)2 and BMI1

DIOPT Version :10

• Sequence 1: NP_001260933.1
• Gene: Su(z)2 / 36432
• FlyBaseID: FBgn0265623
• Length: 1396
• Species: Drosophila melanogaster
• Sequence 2: NP_005171.4
• Gene: BMI1 / 648
• HGNCID: 1066
• Length: 326
• Species: Homo sapiens
• Alignment Length: 343
• Identity: 102/343 - (29%)
• Similarity: 151/343 - (44%)
• Gaps: 57/343 - (16%)

  Fly    26 VRQFHDLITCRLCRGYMIDPTTVDYCYHTYCRSCILKHLLRAVYCPECKASGGKEINELNLKSDD 90
            :.:.:..:.|.||.||.||.||:..|.|::|::||:::|..:.|||.|.....|....||::||.
Human     9 ITELNPHLMCVLCGGYFIDATTIIECLHSFCKTCIVRYLETSKYCPICDVQVHKTRPLLNIRSDK 73

  Fly    91 TLRSLIYKLVPGLYQRECKELADFKEQHDLVD----------EQTTDEPEFFTTTELISLSLEYH 145
            ||:.::|||||||::.|.|...||...|...|          |...::....|..|:||||:|:.
Human    74 TLQDIVYKLVPGLFKNEMKRRRDFYAAHPSADAANGSNEDRGEVADEDKRIITDDEIISLSIEFF 138

  Fly   146 PAML--------HQCGPGEVPPTIYLQCAAGLPVELLKRFLCSKYNIETDNGLVEVEVTYKDEVL 202
            ....        .:....||....||:|.|.:.|..|::||.||.:|.   ...:::|.|::|.|
Human   139 DQNRLDRKVNKDKEKSKEEVNDKRYLRCPAAMTVMHLRKFLRSKMDIP---NTFQIDVMYEEEPL 200

  Fly   203 PTNFTLMDVAYCYNWSRESPMAFCYRILLYDNEQTKNDENNLSRINQDIEPE-HSVRRSKSAKSV 266
            ...:||||:||.|.|.|..|:...||                      :.|. ..::.|.....:
Human   201 KDYYTLMDIAYIYTWRRNGPLPLKYR----------------------VRPTCKRMKISHQRDGL 243

  Fly   267 TFAEDLESEIDSGSPR---------SKVRCKTPPKVSPSSKNKRL--TSSKREAEPESPVSNFKS 320
            |.|.:|||  ||||.:         |...|...|.....|.:.:.  .||.......||..|.:|
Human   244 TNAGELES--DSGSDKANSPAGGIPSTSSCLPSPSTPVQSPHPQFPHISSTMNGTSNSPSGNHQS 306

  Fly   321 LRSNDMRYSDYAVSKVKS 338
            ..:|..|.|....|...|
Human   307 SFANRPRKSSVNGSSATS 324

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(z)2	NP_001260933.1	RING-HC_PCGF5	23..117	CDD:438395	37/90 (41%)
		RAWUL_PCGF2_like	137..228	CDD:340602	32/98 (33%)
BMI1	NP_005171.4	RING-HC_PCGF4	5..101	CDD:438394	37/91 (41%)
		Nuclear localization signal. /evidence=ECO:0000255	81..95		8/13 (62%)
		RAWUL_PCGF4	130..226	CDD:340685	32/98 (33%)
		Interaction with PHC2. /evidence=ECO:0000269|PubMed:27827373	162..182		8/19 (42%)
		Interaction with E4F1. /evidence=ECO:0000269|PubMed:16882984	164..228		26/88 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	236..326		25/91 (27%)