DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(z)2 and Psc

DIOPT Version :9

Sequence 1:	NP_001260933.1	Gene:	Su(z)2 / 36432	FlyBaseID:	FBgn0265623	Length:	1396	Species:	Drosophila melanogaster
Sequence 2:	NP_001286368.1	Gene:	Psc / 36431	FlyBaseID:	FBgn0005624	Length:	1601	Species:	Drosophila melanogaster

Alignment Length:	1526	Identity:	339/1526 - (22%)
Similarity:	550/1526 - (36%)	Gaps:	443/1526 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 ITCRLCRGYMIDPTTVDYCYHTYCRSCILKHLLRAVYCPECKASGGKEINEL--NLKSDDTLRSL 95
            |.|.||:||:|:.||:..|.|::|.||::.||.:..:||.|:    ..||..  |:|||.||:::
  Fly   261 IICHLCQGYLINATTIVECLHSFCHSCLINHLRKERFCPRCE----MVINNAKPNIKSDTTLQAI 321

  Fly    96 IYKLVPGLYQRE-CKELADFKEQHD----LVDEQTTDEPE--FFTTTELISLSLEYHPAMLHQCG 153
            :||||||||:|| .::.|.:|::.:    ...||..|:.|  .|:.::.:||||||  |.|.:..
  Fly   322 VYKLVPGLYERELMRKRAFYKDRPEEAALATPEQRGDDTEHLIFSPSDDMSLSLEY--AELGELK 384

  Fly   154 PGEVPPTI------YLQCAAGLPVELLKRFLCSKYNIETDNGLVEVEVTYKDEVLPTNFTLMDVA 212
            ....|..:      ||||.|...|..||:|:..|:.|:.....:::....|..||...:||||:|
  Fly   385 TDSEPELVDTLRPRYLQCPAMCRVSHLKKFVYDKFEIDAQRFSIDIMYKVKTIVLLDYYTLMDIA 449

  Fly   213 YCYNWSRESPMAFCYRILLYDNEQTKNDENNLSRINQDIEPEHSVRRSKSAKSVTFAEDLESEID 277
            |.|.|.|::||.|.||:  |::.|
  Fly   450 YIYTWKRDAPMRFYYRV--YESPQ----------------------------------------- 471

  Fly   278 SGSPRSKVRCKTPPKVSPSSKNKRLTSSKREAEPESPVSNFKSLRSNDMRYSDYAVSKVKSEPEQ 342
                         |.|.|:.  :|:...|.|          |..|.|..:.....|:..|.||..
  Fly   472 -------------PLVKPAP--RRVLPLKLE----------KQERENQEQQLAVEVASSKVEPVS 511

  Fly   343 EQFLLPREREQQPLEANTNI----------------VVSIPPSQLRKSYVDAEDFELKTANRKGV 391
                ||   |.|..||:..:                |.:.||::..|..::.     ...:::..
  Fly   512 ----LP---EDQKAEASIKVEEQESTREIVKEVIKDVAATPPTETLKLVINR-----NMLDKREK 564

  Fly   392 GHLPKLKIELNSMKSKLSMPLSAGPRLEDTSCSLSCSAQQ----LDLETYAKNIGLKPIEQPLQQ 452
            .|.|::..: :|.||....|:|: |...:....:..|.|.    :|:....:...:||: :|.::
  Fly   565 SHSPQMSSK-SSSKSSPCTPVSS-PSEPNIKLKIDLSKQNSVTIIDMSDPERREIVKPL-KPEKE 626

  Fly   453 SASNPDSKYSPNASPMSSCSSSTNGSSSSLGTADASTSTSTSSSHRKRKKKHSKEPKDANGKRKK 517
            |.|....|   :.||.||.|||                 |:||..||||   |..|........:
  Fly   627 SRSKKKDK---DGSPKSSSSSS-----------------SSSSGERKRK---SPSPLTVPPLTIR 668

  Fly   518 LHAEISSQTDGKMKVKITA---KPNHKLDFKRSHSLASGELDLQKLKLDSTSTSEALNRTLGEEA 579
            ....:|......:..::|:   ..:.|.:|.:|.:|..     .|:|::|.      .|||...|
  Fly   669 TERIMSPSGVSTLSPRVTSGAFSEDPKSEFLKSFALKP-----IKVKVESP------ERTLNNRA 722

  Fly   580 RSINSLVVGGAPTPPPTPTAEPEQQQQ-------QQQQQQQPQQQQQQQQQQQQQQQFVVLPKIK 637
            .:        .|:|....:|.|:.:..       .:.....|.:.....:::.::....|..|.|
  Fly   723 IT--------PPSPSVQQSASPKSKGNNLDDSILMKPPSCMPPKSIASSKRKSKEPVKAVSKKQK 779

  Fly   638 DLTLPTSPPLPPSLFKAYTPSTTPTAPHTVAGGKPKQQQQQMPQQPQAVLQQSLAKTNPAKPPLS 702
                 .|||||...||...|.|...:..|.:   ||.::..||.              |||||:.
  Fly   780 -----LSPPLPTVDFKIRLPVTNGNSSGTAS---PKIEKPLMPP--------------PAKPPML 822

  Fly   703 SNNNRKPNSGHFAVPQAPTHRNMYHMQRYQSTPSSIASAANK----MPKRS-------MSLDESH 756
            :....:| |..||.|.:|.|   :|.....|.|.:....|.:    :||.|       :..|.:.
  Fly   823 APRKLQP-SAQFAPPPSPIH---HHAGVQMSAPGNRTPIAKRYQPILPKASRPNPFANIPNDVNR 883

  Fly   757 PAKQARLSQAQAMA-------SSYAAKLHMQTSNQAKSQAAAFLP--NPQMRSYGLPDLGSKP-T 811
            ..|.|. ::.:::.       |:.|.|.|:.............||  .|   |.|..::|.:. .
  Fly   884 LLKDAG-TEIKSIGGGSVENNSNAAQKPHLYGPKGESKMGPPALPATTP---SQGNKNVGKQAGN 944

  Fly   812 LPMLCPA----SSSSQVTIT----------------PRPRATPS--IYSFSEPNIHVPALEIVRL 854
            |||..|.    ||::.:.:.                ..|..||:  |||.|.|. :||:..|..:
  Fly   945 LPMSAPPNKGNSSNNYLNLALFNSSKCKGKEAPPGCRTPMYTPNSPIYSPSSPQ-YVPSYNIPTM 1008

  Fly   855 PVNKQS----------------------AGGKGLTMPPLSP-PATSSARLMGPP-----AALPKH 891
            |..|.:                      .||.|.::..|.| |.|.|.:...|.     ::....
  Fly  1009 PTYKYTPKPTPNSGSGNGGSGSYLQNMLGGGNGGSLGGLFPSPPTKSDQNTNPAQGGGGSSSATQ 1073

  Fly   892 AGHGHGAAKRSCQMPTMPMPLPLPLPMPMTTIPAIVKS----PPLSVALSGQRNNKGNSSNSNAY 952
            :|..:|....:..||....|     ......:.:::.|    .|.|::::..|:|..:||.:|..
  Fly  1074 SGGNNGIVNNNIYMPNEDAP-----EKQQVKVKSLLNSCNINIPSSLSITISRDNGDSSSPNNGQ 1133

  Fly   953 ---------------------------------RTSPPALINLRNTA------------APQH-- 970
                                             |.||||.:.....|            :|||
  Fly  1134 HPKHKSPVNNYIEIVKLPDQPQDQVQAAKEAQKRQSPPAAVPGHLAAKLPPPPPSKAIPSPQHLV 1198

  Fly   971 ------------SFPSKSSPKVEANSKKSPPAAGCQG---KTNGTAALDKSKTSLREFRPAVQSA 1020
                        :.|..|||:|....|.||||...:.   |...|......||...|.|.|.|..
  Fly  1199 SRMTPPQLPKVATPPPPSSPRVITPPKTSPPANAAKVTPLKPVLTPTQVDKKTPSPEKRTAAQMG 1263

  Fly  1021 VTATATTSVTTAAGAGAGAGTGTGTA-------------LAKDADILDLS--------------- 1057
            ..:...:...:..|..||....||.|             |.:...:.:|:
  Fly  1264 SHSPTASENKSPKGGPAGVANSTGGAQNGDPAAKKFRPILPRQNGMPELAPKLPTLAPFVGFNPL 1328

  Fly  1058 ANP--GRSNNDAKLAPNSPPAGNNNNNNNNNNNNNNNNNNNNNNSTSNSLEAALNKIKQN----- 1115
            .||  |:....:|.:||:..|.:.:......|...:.......:..:...:..:.|:.:|
  Fly  1329 QNPAAGKKVPPSKKSPNAGAAAHQSGQQKLVNGGQSQPAQQKTSPPAQKNQQQVKKVSKNPTPPP 1393

  Fly  1116 -------------ISANSNGGPSTTSGSNSNGTTNGD-DLQNLHMLSE------SATAREKISIK 1160
                         :..:.|...|..|.:::....:|. ||.|  .|.|      :|.|.:...:.
  Fly  1394 PSLPAVGKMMPHPVMHSQNAPLSIASSASAAAVASGQLDLSN--FLKENLRRVHAAQAAQAAQVA 1456

  Fly  1161 AASSG-----NGSGSTSSSSAKPKNANALVRPQNASVRSIPNPSALAFRNQPAAASTAASISKPL 1220
            ||::.     |.:.....:.|......|..|.|.:.::.:.|.   .|.:......|||:.....
  Fly  1457 AAANQSNMMYNLAQMGHMTPAMYNYQQAYFREQLSRMQRVGNE---VFNDYLQKLKTAAATGGGG 1518

  Fly  1221 TVRAEEKPKVST---SNPGSLSPTN------------TSSSSSSSSSGSSGCSAATSPRAMTKKP 1270
            .|..|.||.:.|   .:||:..|..            |:::::..:.|:|...||.:.:
  Fly  1519 PVEGELKPMLPTVTLPSPGATPPAASPKTSPLPAGKLTAAATAPQTKGNSSSGAANARQ------ 1577

  Fly  1271 TTIDQVAANLNIRAEAKAAALAEEAPPVLSS 1301
                |.||..|..|...||:|    ||...|
  Fly  1578 ----QTAATGNNGATVPAASL----PPATKS 1600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(z)2	NP_001260933.1	zf-C3HC4	35..73	CDD:278524	17/37 (46%)
Su(z)2	NP_001260933.1	RAWUL	143..228	CDD:292824	31/90 (34%)
Psc	NP_001286368.1	zf-C3HC4	263..301	CDD:278524	17/37 (46%)
Psc	NP_001286368.1	RAWUL	384..465	CDD:292824	27/80 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45441207
Domainoid	1	1.000	52	1.000	Domainoid score	I4257
eggNOG	1	0.900	-	-		E1_KOG2660
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1203951at2759
OrthoFinder	1	1.000	-	-		FOG0000290
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10825
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.850