Protein Alignment Psc and PCGF1

DIOPT Version :9

• Sequence 1: NP_001286368.1
• Gene: Psc / 36431
• FlyBaseID: FBgn0005624
• Length: 1601
• Species: Drosophila melanogaster
• Sequence 2: NP_116062.2
• Gene: PCGF1 / 84759
• HGNCID: 17615
• Length: 259
• Species: Homo sapiens
• Alignment Length: 232
• Identity: 75/232 - (32%)
• Similarity: 124/232 - (53%)
• Gaps: 26/232 - (11%)

  Fly   252 VLLTAVNPHIICHLCQGYLINATTIVECLHSFCHSCLINHLRKERFCPRCEMVINNAKP--NIKS 314
            |.:..:|.||:|.||.||.::||||.||||:||.||::.:|:..::||.|.:.|:..:|  |:|.
Human    36 VKIKDLNEHIVCCLCAGYFVDATTITECLHTFCKSCIVKYLQTSKYCPMCNIKIHETQPLLNLKL 100

  Fly   315 DTTLQAIVYKLVPGLYERELMRKRAFYKDR---------PEEAALAT---PEQRGDDTEHLIFSP 367
            |..:|.|||||||||.:.|..|.|.||:.|         .||.||:.   |....|.::...:..
Human   101 DRVMQDIVYKLVPGLQDSEEKRIREFYQSRGLDRVTQPTGEEPALSNLGLPFSSFDHSKAHYYRY 165

  Fly   368 SDDMSLSLEYAELGELKTDSEPELVDTLRPRYLQCPAMCRVSHLKKFVYDKFEIDAQRFSIDIMY 432
            .:.::|.||....|:.|..|      .|:.:|::|.....|.||::.:..:..::.|.  :.:::
Human   166 DEQLNLCLERLSSGKDKNKS------VLQNKYVRCSVRAEVRHLRRVLCHRLMLNPQH--VQLLF 222

  Fly   433 KVKTIVLLDYYTLMDIAYIYTW-KRDAPMRFYYRVYE 468
            ..:  ||.|:.|:..| ::..| .:.:|:...|.|.|
Human   223 DNE--VLPDHMTMKQI-WLSRWFGKPSPLLLQYSVKE 256

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Psc	NP_001286368.1	zf-C3HC4	263..301	CDD:278524	20/37 (54%)
		RAWUL	384..465	CDD:292824	16/81 (20%)
PCGF1	NP_116062.2	RING-HC_PCGF1	44..86	CDD:319647	22/41 (54%)
		RING-HC finger (C3HC4-type)	47..85	CDD:319647	20/37 (54%)
		Required for repressor activity	86..247		46/171 (27%)
		Required for the interaction with the KDM2B-SKP1 heterodimeric complex. /evidence=ECO:0000269|PubMed:27568929	150..255		23/115 (20%)
		RAWUL_PCGF1	166..253	CDD:340601	20/97 (21%)
		RING-finger and WD40-associated ubiquitin-like domain (RAWUL), sufficient for interaction with BCOR and BCORL1. /evidence=ECO:0000269|PubMed:23523425, ECO:0000269|PubMed:27568929	167..255		21/98 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157888
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2660
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1203951at2759
OrthoFinder	1	1.000	-	-		FOG0000290
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750