DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Psc and bmi1b

DIOPT Version :9

Sequence 1:	NP_001286368.1	Gene:	Psc / 36431	FlyBaseID:	FBgn0005624	Length:	1601	Species:	Drosophila melanogaster
Sequence 2:	XP_021335136.1	Gene:	bmi1b / 394249	ZFINID:	ZDB-GENE-040116-4	Length:	326	Species:	Danio rerio

Alignment Length:	360	Identity:	127/360 - (35%)
Similarity:	183/360 - (50%)	Gaps:	81/360 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 TTSRPRPVLLTAVNPHIICHLCQGYLINATTIVECLHSFCHSCLINHLRKERFCPRCEMVINNAK 309
            |..|...:.:|.:|||::|.||.||.|:||||||||||||..|::.:|...::||.|::.::..|
Zfish     2 TMHRTTRIKITELNPHLMCVLCGGYFIDATTIVECLHSFCKMCIVRYLETSKYCPICDVQVHKTK 66

  Fly   310 P--NIKSDTTLQAIVYKLVPGLYERELMRKRAFYKDRPEEAALATPEQRGD--DTEHLIFSPSDD 370
            |  ||:||.|||.|||||||||::.|:.|:|.||.:.|.:|...:.|.||:  |.:..|.:..:.
Zfish    67 PLLNIRSDKTLQDIVYKLVPGLFKNEMKRRRDFYAEHPVDATNGSNEDRGEVSDEDKRIIADDEI 131

  Fly   371 MSLSLEYAELGEL--KTDSEPELV-DTLRPRYLQCPAMCRVSHLKKFVYDKFEIDAQRFSIDIMY 432
            :|||:|:.:..:|  |...|.|.. :....|||||||...|.||:||:..|.:|.. .|.|::||
Zfish   132 ISLSIEFFDQKKLDGKDGEEKESTKEVTVKRYLQCPAAMTVMHLRKFLRSKMDIPC-TFQIEVMY 195

  Fly   433 KVKTIVLLDYYTLMDIAYIYTWKRDAPMRFYYRVYESPQPLVKPAPRRVLPLKLEKQERENQEQQ 497
            :.:.  |.||||||||||||||:|:.|:...||        |:|..:::
Zfish   196 EDEP--LKDYYTLMDIAYIYTWRRNGPLPLKYR--------VRPGCKKI---------------- 234

  Fly   498 LAVEVASSKVEPVSLPEDQKAEASIKVEEQESTREIVKEVIKDVAATPPTETLKLVINRNMLDKR 562
                       .:|.|.:..:.......|.:|:                               .
Zfish   235 -----------KLSSPRNDMSGGRRPDTESDSS-------------------------------S 257

  Fly   563 EKSHSPQM---SSKSSSKSSPCTPVSS--PSEPNI 592
            :|.:||.:   .|.|||..||.|||.|  ||.|:|
Zfish   258 DKPNSPSIVAAPSTSSSMPSPNTPVQSTHPSFPHI 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Psc	NP_001286368.1	zf-C3HC4	263..301	CDD:278524	22/37 (59%)
Psc	NP_001286368.1	RAWUL	384..465	CDD:292824	38/81 (47%)
bmi1b	XP_021335136.1	RAD18	10..>153	CDD:333230	64/142 (45%)
		RING-HC_PCGF4	14..67	CDD:319650	26/52 (50%)
		RING-HC finger (C3HC4-type)	20..58	CDD:319650	22/37 (59%)
		RAWUL	162..226	CDD:318447	35/66 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593701
Domainoid	1	1.000	75	1.000	Domainoid score	I9014
eggNOG	1	0.900	-	-		E1_KOG2660
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000290
OrthoInspector	1	1.000	-	-		otm24402
orthoMCL	1	0.900	-	-		OOG6_107240
Panther	1	1.100	-	-	O	PTHR10825
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4728
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.730