DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Psc and Su(z)2

DIOPT Version :9

Sequence 1:	NP_001286368.1	Gene:	Psc / 36431	FlyBaseID:	FBgn0005624	Length:	1601	Species:	Drosophila melanogaster
Sequence 2:	NP_001260933.1	Gene:	Su(z)2 / 36432	FlyBaseID:	FBgn0265623	Length:	1396	Species:	Drosophila melanogaster

Alignment Length:	1526	Identity:	339/1526 - (22%)
Similarity:	550/1526 - (36%)	Gaps:	443/1526 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   261 IICHLCQGYLINATTIVECLHSFCHSCLINHLRKERFCPRCE----MVINNAKPNIKSDTTLQAI 321
            |.|.||:||:|:.||:..|.|::|.||::.||.:..:||.|:    ..||..  |:|||.||:::
  Fly    33 ITCRLCRGYMIDPTTVDYCYHTYCRSCILKHLLRAVYCPECKASGGKEINEL--NLKSDDTLRSL 95

  Fly   322 VYKLVPGLYERELMRKRAFYKDRPEEAALATPEQRGDDTEHLIFSPSDDMSLSLEY--AELGELK 384
            :||||||||:|| .::.|.:|::.:    ...||..|:.|  .|:.::.:||||||  |.|.:..
  Fly    96 IYKLVPGLYQRE-CKELADFKEQHD----LVDEQTTDEPE--FFTTTELISLSLEYHPAMLHQCG 153

  Fly   385 TDSEPELVDTLRPRYLQCPAMCRVSHLKKFVYDKFEIDAQRFSIDIMYKVKTIVLLDYYTLMDIA 449
            ....|..:      ||||.|...|..||:|:..|:.|:.....:::....|..||...:||||:|
  Fly   154 PGEVPPTI------YLQCAAGLPVELLKRFLCSKYNIETDNGLVEVEVTYKDEVLPTNFTLMDVA 212

  Fly   450 YIYTWKRDAPMRFYYRV--YESPQ----------------------------------------- 471
            |.|.|.|::||.|.||:  |::.|
  Fly   213 YCYNWSRESPMAFCYRILLYDNEQTKNDENNLSRINQDIEPEHSVRRSKSAKSVTFAEDLESEID 277

  Fly   472 -------------PLVKPAP--RRVLPLKLE----------KQERENQEQQLAVEVASSKVEPVS 511
                         |.|.|:.  :|:...|.|          |..|.|..:.....|:..|.||..
  Fly   278 SGSPRSKVRCKTPPKVSPSSKNKRLTSSKREAEPESPVSNFKSLRSNDMRYSDYAVSKVKSEPEQ 342

  Fly   512 ----LP---EDQKAEASIKVEEQESTREIVKEVIKDVAATPPTETLKLVINR-----NMLDKREK 564
                ||   |.|..||:..:                |.:.||::..|..::.     ...:::..
  Fly   343 EQFLLPREREQQPLEANTNI----------------VVSIPPSQLRKSYVDAEDFELKTANRKGV 391

  Fly   565 SHSPQMSSK-SSSKSSPCTPVSS-PSEPNIKLKIDLSKQNSVTIIDMSDPERREIVKPL-KPEKE 626
            .|.|::..: :|.||....|:|: |...:....:..|.|.    :|:....:...:||: :|.::
  Fly   392 GHLPKLKIELNSMKSKLSMPLSAGPRLEDTSCSLSCSAQQ----LDLETYAKNIGLKPIEQPLQQ 452

  Fly   627 SRSKKKDK---DGSPKSSSSSS-----------------SSSSGERKRK---SPSPLTVPPLTIR 668
            |.|....|   :.||.||.|||                 |:||..||||   |..|........:
  Fly   453 SASNPDSKYSPNASPMSSCSSSTNGSSSSLGTADASTSTSTSSSHRKRKKKHSKEPKDANGKRKK 517

  Fly   669 TERIMSPSGVSTLSPRVTSGAFSEDPKSEFLKSFALKP-----IKVKVESP------ERTLNNRA 722
            ....:|......:..::|:   ..:.|.:|.:|.:|..     .|:|::|.      .|||...|
  Fly   518 LHAEISSQTDGKMKVKITA---KPNHKLDFKRSHSLASGELDLQKLKLDSTSTSEALNRTLGEEA 579

  Fly   723 IT--------PPSPSVQQSASPKSKGNNLDDSILMKPPSCMPPKSIASSKRKSKEPVKAVSKKQK 779
            .:        .|:|....:|.|:.:..       .:.....|.:.....:::.::....|..|.|
  Fly   580 RSINSLVVGGAPTPPPTPTAEPEQQQQ-------QQQQQQQPQQQQQQQQQQQQQQQFVVLPKIK 637

  Fly   780 -----LSPPLPTVDFKIRLPVTNGNSSGTAS---PKIEKPLMPP--------------PAKPPML 822
                 .|||||...||...|.|...:..|.:   ||.::..||.              |||||:.
  Fly   638 DLTLPTSPPLPPSLFKAYTPSTTPTAPHTVAGGKPKQQQQQMPQQPQAVLQQSLAKTNPAKPPLS 702

  Fly   823 APRKLQP-SAQFAPPPSPIH---HHAGVQMSAPGNRTPIAKRYQPILPKASRPNPFANIPNDVNR 883
            :....:| |..||.|.:|.|   :|.....|.|.:....|.:    :||.|       :..|.:.
  Fly   703 SNNNRKPNSGHFAVPQAPTHRNMYHMQRYQSTPSSIASAANK----MPKRS-------MSLDESH 756

  Fly   884 LLKDAG-TEIKSIGGGSVENNSNAAQKPHLYGPKGESKMGPPALPATTP---SQGNKNVGKQAGN 944
            ..|.|. ::.:::.       |:.|.|.|:.............||  .|   |.|..::|.:. .
  Fly   757 PAKQARLSQAQAMA-------SSYAAKLHMQTSNQAKSQAAAFLP--NPQMRSYGLPDLGSKP-T 811

  Fly   945 LPMSAPPNKGNSSNNYLNLALFNSSKCKGKEAPPGCRTPMYTPNSPIYSPSSPQ-YVPSYNIPTM 1008
            |||..|.    ||::.:.:.                ..|..||:  |||.|.|. :||:..|..:
  Fly   812 LPMLCPA----SSSSQVTIT----------------PRPRATPS--IYSFSEPNIHVPALEIVRL 854

  Fly  1009 PTYKYTPKPTPNSGSGNGGSGSYLQNMLGGGNGGSLGGLFPSPPTKSDQNTNPAQGGGGSSSATQ 1073
            |..|.:                      .||.|.::..|.| |.|.|.:...|.     ::....
  Fly   855 PVNKQS----------------------AGGKGLTMPPLSP-PATSSARLMGPP-----AALPKH 891

  Fly  1074 SGGNNGIVNNNIYMPNEDAP-----EKQQVKVKSLLNSCNINIPSSLSITISRDNGDSSSPNNGQ 1133
            :|..:|....:..||....|     ......:.:::.|    .|.|::::..|:|..:||.:|..
  Fly   892 AGHGHGAAKRSCQMPTMPMPLPLPLPMPMTTIPAIVKS----PPLSVALSGQRNNKGNSSNSNAY 952

  Fly  1134 HPKHKSPVNNYIEIVKLPDQPQDQVQAAKEAQKRQSPPAAVPGHLAAKLPPPPPSKAIPSPQHLV 1198
                                             |.||||.:.....|            :|||
  Fly   953 ---------------------------------RTSPPALINLRNTA------------APQH-- 970

  Fly  1199 SRMTPPQLPKVATPPPPSSPRVITPPKTSPPANAAKVTPLKPVLTPTQVDKKTPSPEKRTAAQMG 1263
                        :.|..|||:|....|.||||...:.   |...|......||...|.|.|.|..
  Fly   971 ------------SFPSKSSPKVEANSKKSPPAAGCQG---KTNGTAALDKSKTSLREFRPAVQSA 1020

  Fly  1264 SHSPTASENKSPKGGPAGVANSTGGAQNGDPAAKKFRPILPRQNGMPELAPKLPTLAPFVGFNPL 1328
            ..:...:...:..|..||....||.|             |.:...:.:|:
  Fly  1021 VTATATTSVTTAAGAGAGAGTGTGTA-------------LAKDADILDLS--------------- 1057

  Fly  1329 QNPAAGKKVPPSKKSPNAGAAAHQSGQQKLVNGGQSQPAQQKTSPPAQKNQQQVKKVSKNPTPPP 1393
            .||  |:....:|.:||:..|.:.:......|...:.......:..:...:..:.|:.:|
  Fly  1058 ANP--GRSNNDAKLAPNSPPAGNNNNNNNNNNNNNNNNNNNNNNSTSNSLEAALNKIKQN----- 1115

  Fly  1394 PSLPAVGKMMPHPVMHSQNAPLSIASSASAAAVASGQLDLSN--FLKENLRRVHAAQAAQAAQVA 1456
                         :..:.|...|..|.:::....:|. ||.|  .|.|      :|.|.:...:.
  Fly  1116 -------------ISANSNGGPSTTSGSNSNGTTNGD-DLQNLHMLSE------SATAREKISIK 1160

  Fly  1457 AAANQSNMMYNLAQMGHMTPAMYNYQQAYFREQLSRMQRVGNE---VFNDYLQKLKTAAATGGGG 1518
            ||::.     |.:.....:.|......|..|.|.:.::.:.|.   .|.:......|||:.....
  Fly  1161 AASSG-----NGSGSTSSSSAKPKNANALVRPQNASVRSIPNPSALAFRNQPAAASTAASISKPL 1220

  Fly  1519 PVEGELKPMLPTVTLPSPGATPPAASPKTSPLPAGKLTAAATAPQTKGNSSSGAANARQ------ 1577
            .|..|.||.:.|   .:||:..|..            |:::::..:.|:|...||.:.:
  Fly  1221 TVRAEEKPKVST---SNPGSLSPTN------------TSSSSSSSSSGSSGCSAATSPRAMTKKP 1270

  Fly  1578 ----QTAATGNNGATVPAASL----PPATKS 1600
                |.||..|..|...||:|    ||...|
  Fly  1271 TTIDQVAANLNIRAEAKAAALAEEAPPVLSS 1301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Psc	NP_001286368.1	zf-C3HC4	263..301	CDD:278524	17/37 (46%)
Psc	NP_001286368.1	RAWUL	384..465	CDD:292824	27/80 (34%)
Su(z)2	NP_001260933.1	zf-C3HC4	35..73	CDD:278524	17/37 (46%)
Su(z)2	NP_001260933.1	RAWUL	143..228	CDD:292824	31/90 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45441207
Domainoid	1	1.000	52	1.000	Domainoid score	I4257
eggNOG	1	0.900	-	-		E1_KOG2660
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1203951at2759
OrthoFinder	1	1.000	-	-		FOG0000290
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10825
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.850