DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Psc and Ring1

DIOPT Version :9

Sequence 1:	NP_001286368.1	Gene:	Psc / 36431	FlyBaseID:	FBgn0005624	Length:	1601	Species:	Drosophila melanogaster
Sequence 2:	NP_997714.2	Gene:	Ring1 / 309626	RGDID:	3576	Length:	406	Species:	Rattus norvegicus

Alignment Length:	193	Identity:	46/193 - (23%)
Similarity:	82/193 - (42%)	Gaps:	32/193 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 TAAVAASSTATTTSDLATTSR-PRPVLL----TAVNP-----HIICHLCQGYLINATTIVECLHS 282
            |.|.|.:::.|....|....| |:..::    .||:|     .::|.:|...|.|..|..||||.
  Rat     3 TPANAQNASKTWELSLYELHRTPQEAIMDGTEIAVSPRSLHSELMCPICLDMLKNTMTTKECLHR 67

  Fly   283 FCHSCLINHLRK-ERFCPRCEMVINNAKPNIKSDTTLQAIVYKLVPGLYERELMRKRAFYK--DR 344
            ||..|::..||. .:.||.|...: .:|.:::.|....|::.|:.|...|.|..:.|...:  ..
  Rat    68 FCSDCIVTALRSGNKECPTCRKKL-VSKRSLRPDPNFDALISKIYPSREEYEAHQDRVLIRLSRL 131

  Fly   345 PEEAALATPEQRGDDTEHLIFS-------PSDDMSLSLEYAELGE----------LKTDSEPE 390
            ..:.||::..:.|...:.:..:       |..|.:.::...| ||          :.:||.|:
  Rat   132 HNQQALSSSIEEGLRMQAMHRAQRVRRPMPGSDQTTTMSGGE-GEPGEGEGDGEDISSDSAPD 193

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Psc	NP_001286368.1	zf-C3HC4	263..301	CDD:278524	16/38 (42%)
Psc	NP_001286368.1	RAWUL	384..465	CDD:292824	3/7 (43%)
Ring1	NP_997714.2	Necessary for transcriptional repression. /evidence=ECO:0000250	30..234		39/166 (23%)
		RING-HC_RING1	47..90	CDD:319653	17/42 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..263		8/44 (18%)
		Nuclear localization signal. /evidence=ECO:0000250	201..204
		Necessary for interaction with CBX2. /evidence=ECO:0000250	230..406
		RAWUL_RING1	261..400	CDD:340686
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	309..354
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351894
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840