DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Psc and Ring1

DIOPT Version :9

Sequence 1:	NP_001286368.1	Gene:	Psc / 36431	FlyBaseID:	FBgn0005624	Length:	1601	Species:	Drosophila melanogaster
Sequence 2:	NP_033092.3	Gene:	Ring1 / 19763	MGIID:	1101770	Length:	406	Species:	Mus musculus

Alignment Length:	126	Identity:	35/126 - (27%)
Similarity:	58/126 - (46%)	Gaps:	12/126 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 TAAVAASSTATTTSDLATTSR-PRPVLL----TAVNP-----HIICHLCQGYLINATTIVECLHS 282
            |.|.|.:::.|....|....| |:..::    .||:|     .::|.:|...|.|..|..||||.
Mouse     3 TPANAQNASKTWELSLYELHRTPQEAIMDGTEIAVSPRSLHSELMCPICLDMLKNTMTTKECLHR 67

  Fly   283 FCHSCLINHLRK-ERFCPRCEMVINNAKPNIKSDTTLQAIVYKLVPGLYERELMRKRAFYK 342
            ||..|::..||. .:.||.|...: .:|.:::.|....|::.|:.|...|.|..:.|...:
Mouse    68 FCSDCIVTALRSGNKECPTCRKKL-VSKRSLRPDPNFDALISKIYPSREEYEAHQDRVLIR 127

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Psc	NP_001286368.1	zf-C3HC4	263..301	CDD:278524	16/38 (42%)
Psc	NP_001286368.1	RAWUL	384..465	CDD:292824
Ring1	NP_033092.3	Necessary for transcriptional repression	30..234		28/99 (28%)
		zf-C3HC4	48..87	CDD:278524	16/38 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..263
		Nuclear localization signal. /evidence=ECO:0000250	201..204
		Necessary for interaction with CBX2. /evidence=ECO:0000269\|PubMed:9312051	230..406
		RAWUL	280..400	CDD:292824
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	309..354
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848282
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840