DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13321 and RFWD3

DIOPT Version :9

Sequence 1:	NP_001286367.1	Gene:	CG13321 / 36430	FlyBaseID:	FBgn0033787	Length:	286	Species:	Drosophila melanogaster
Sequence 2:	NP_001357463.1	Gene:	RFWD3 / 55159	HGNCID:	25539	Length:	774	Species:	Homo sapiens

Alignment Length:	289	Identity:	57/289 - (19%)
Similarity:	80/289 - (27%)	Gaps:	113/289 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 QEISKHDFEVLVGDHFS--WI----PSSGGSVPPH--------AIQVGQTGEG---------EPL 102
            |:::.|..:.|.....|  |:    |||.|.   |        ...|.|.|..         ..|
Human   401 QKLTSHQSQNLQQPRGSQAWVLSCSPSSQGQ---HKHKYHFQKTFTVSQAGNCRIMAYCDALSCL 462

  Fly   103 YVGRGYFQGSLTPG------KVHPSHQCLYIPYGGQEHRLEAYEVLVQPETWIASSGR-----GI 156
            .:.:...|.|..||      .........|||..|::.|..|:...::.....||...     .:
Human   463 VISQPSPQASFLPGFGVKMLSTANMKSSQYIPMHGKQIRGLAFSSYLRGLLLSASLDNTIKLTSL 527

  Fly   157 VPGTVVGGHDA------------DGDQIYVGRA-------------YHEGDLLPAKV-------- 188
            ...|||..::|            :.:.||.|.|             .|..:|:..|.
Human   528 ETNTVVQTYNAGRPVWSCCWCLDEANYIYAGLANGSILVYDVRNTSSHVQELVAQKARCPLVSLS 592

  Fly   189 -IPNKGCAYVPYGGGEVVKHDYELLAGYGYGWVHDSHGNVPGNAVLCGRTSDG----EPLFIGRA 248
             :|....|..||||                              ||.|...|.    :.:.....
Human   593 YMPRAASAAFPYGG------------------------------VLAGTLEDASFWEQKMDFSHW 627

  Fly   249 HHHGSLTPGKI------HQSHHCL--YIP 269
            .|...|.||..      :.|.|||  |.|
Human   628 PHVLPLEPGGCIDFQTENSSRHCLVTYRP 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13321	NP_001286367.1	DM9	3..73	CDD:128937	3/11 (27%)
		DUF3421	25..135	CDD:288732	22/102 (22%)
		DM9	75..143	CDD:128937	21/96 (22%)
		DM9	147..215	CDD:128937	19/106 (18%)
		DUF3421	166..276	CDD:288732	28/150 (19%)
		DM9	216..286	CDD:128937	14/66 (21%)
RFWD3	NP_001357463.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..116
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..225
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	257..280
		mRING-C3HGC3_RFWD3	283..331	CDD:319364
		WD40	<486..774	CDD:225201	39/201 (19%)
		WD 1	495..537		8/41 (20%)
		WD40 repeat	500..537	CDD:293791	7/36 (19%)
		WD 2	539..577		5/37 (14%)
		WD40 repeat	543..580	CDD:293791	5/36 (14%)
		WD 3	583..628		11/74 (15%)
		WD40 repeat	588..655	CDD:293791	18/96 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910